Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362545677> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4362545677 abstract "<div>Abstract<p>Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in patients with MCC, but these responses are typically absent. We determined the prevalence and reversibility of major histocompatibility complex class I (MHC-I) downregulation in MCC, a potentially reversible immune-evasion mechanism. Cell-surface MHC-I expression was assessed on five MCC cell lines using flow cytometry as well as immunohistochemistry on tissue microarrays representing 114 patients. Three additional patients were included who had received intralesional IFN treatment and had evaluable specimens before and after treatment. mRNA expression analysis of antigen presentation pathway genes from 35 MCC tumors was used to examine the mechanisms of downregulation. Of note, 84% of MCCs (total <i>n</i> = 114) showed reduced MHC-I expression as compared with surrounding tissues, and 51% had poor or undetectable MHC-I expression. Expression of MHC-I was lower in polyomavirus-positive MCCs than in polyomavirus-negative MCCs (<i>P</i> < 0.01). The MHC-I downregulation mechanism was multifactorial and did not depend solely on HLA gene expression. Treatment of MCC cell lines with ionizing radiation, etoposide, or IFN resulted in MHC-I upregulation, with IFNs strongly upregulating MHC-I expression <i>in vitro</i>, and in 3 of 3 patients treated with intralesional IFNs. MCC tumors may be amenable to immunotherapy, but downregulation of MHC-I is frequently present in these tumors, particularly those that are positive for polyomavirus. This downregulation is reversible with any of several clinically available treatments that may thus promote the effectiveness of immune-stimulating therapies for MCC. <i>Cancer Immunol Res; 2(11); 1071–9. ©2014 AACR</i>.</p></div>" @default.
- W4362545677 created "2023-04-06" @default.
- W4362545677 creator A5001000202 @default.
- W4362545677 creator A5005332655 @default.
- W4362545677 creator A5006964063 @default.
- W4362545677 creator A5010399509 @default.
- W4362545677 creator A5014605629 @default.
- W4362545677 creator A5014794985 @default.
- W4362545677 creator A5018100562 @default.
- W4362545677 creator A5026765226 @default.
- W4362545677 creator A5034786338 @default.
- W4362545677 creator A5039848435 @default.
- W4362545677 creator A5040444549 @default.
- W4362545677 creator A5041018503 @default.
- W4362545677 creator A5052765241 @default.
- W4362545677 creator A5056765901 @default.
- W4362545677 creator A5061716251 @default.
- W4362545677 creator A5067045121 @default.
- W4362545677 creator A5072474288 @default.
- W4362545677 creator A5082643048 @default.
- W4362545677 creator A5085452874 @default.
- W4362545677 creator A5089305253 @default.
- W4362545677 creator A5090963692 @default.
- W4362545677 date "2023-04-03" @default.
- W4362545677 modified "2023-09-27" @default.
- W4362545677 title "Data from Downregulation of MHC-I Expression Is Prevalent but Reversible in Merkel Cell Carcinoma" @default.
- W4362545677 doi "https://doi.org/10.1158/2326-6066.c.6548198.v1" @default.
- W4362545677 hasPublicationYear "2023" @default.
- W4362545677 type Work @default.
- W4362545677 citedByCount "0" @default.
- W4362545677 crossrefType "posted-content" @default.
- W4362545677 hasAuthorship W4362545677A5001000202 @default.
- W4362545677 hasAuthorship W4362545677A5005332655 @default.
- W4362545677 hasAuthorship W4362545677A5006964063 @default.
- W4362545677 hasAuthorship W4362545677A5010399509 @default.
- W4362545677 hasAuthorship W4362545677A5014605629 @default.
- W4362545677 hasAuthorship W4362545677A5014794985 @default.
- W4362545677 hasAuthorship W4362545677A5018100562 @default.
- W4362545677 hasAuthorship W4362545677A5026765226 @default.
- W4362545677 hasAuthorship W4362545677A5034786338 @default.
- W4362545677 hasAuthorship W4362545677A5039848435 @default.
- W4362545677 hasAuthorship W4362545677A5040444549 @default.
- W4362545677 hasAuthorship W4362545677A5041018503 @default.
- W4362545677 hasAuthorship W4362545677A5052765241 @default.
- W4362545677 hasAuthorship W4362545677A5056765901 @default.
- W4362545677 hasAuthorship W4362545677A5061716251 @default.
- W4362545677 hasAuthorship W4362545677A5067045121 @default.
- W4362545677 hasAuthorship W4362545677A5072474288 @default.
- W4362545677 hasAuthorship W4362545677A5082643048 @default.
- W4362545677 hasAuthorship W4362545677A5085452874 @default.
- W4362545677 hasAuthorship W4362545677A5089305253 @default.
- W4362545677 hasAuthorship W4362545677A5090963692 @default.
- W4362545677 hasBestOaLocation W43625456772 @default.
- W4362545677 hasConcept C104317684 @default.
- W4362545677 hasConcept C127561419 @default.
- W4362545677 hasConcept C170627219 @default.
- W4362545677 hasConcept C203014093 @default.
- W4362545677 hasConcept C207936829 @default.
- W4362545677 hasConcept C2776187983 @default.
- W4362545677 hasConcept C2777546739 @default.
- W4362545677 hasConcept C2778342957 @default.
- W4362545677 hasConcept C502942594 @default.
- W4362545677 hasConcept C54355233 @default.
- W4362545677 hasConcept C553184892 @default.
- W4362545677 hasConcept C86803240 @default.
- W4362545677 hasConcept C8891405 @default.
- W4362545677 hasConceptScore W4362545677C104317684 @default.
- W4362545677 hasConceptScore W4362545677C127561419 @default.
- W4362545677 hasConceptScore W4362545677C170627219 @default.
- W4362545677 hasConceptScore W4362545677C203014093 @default.
- W4362545677 hasConceptScore W4362545677C207936829 @default.
- W4362545677 hasConceptScore W4362545677C2776187983 @default.
- W4362545677 hasConceptScore W4362545677C2777546739 @default.
- W4362545677 hasConceptScore W4362545677C2778342957 @default.
- W4362545677 hasConceptScore W4362545677C502942594 @default.
- W4362545677 hasConceptScore W4362545677C54355233 @default.
- W4362545677 hasConceptScore W4362545677C553184892 @default.
- W4362545677 hasConceptScore W4362545677C86803240 @default.
- W4362545677 hasConceptScore W4362545677C8891405 @default.
- W4362545677 hasLocation W43625456771 @default.
- W4362545677 hasLocation W43625456772 @default.
- W4362545677 hasOpenAccess W4362545677 @default.
- W4362545677 hasPrimaryLocation W43625456771 @default.
- W4362545677 hasRelatedWork W1969011653 @default.
- W4362545677 hasRelatedWork W2001310551 @default.
- W4362545677 hasRelatedWork W2041546512 @default.
- W4362545677 hasRelatedWork W2106458784 @default.
- W4362545677 hasRelatedWork W2148440176 @default.
- W4362545677 hasRelatedWork W2172287714 @default.
- W4362545677 hasRelatedWork W3039384063 @default.
- W4362545677 hasRelatedWork W4361944948 @default.
- W4362545677 hasRelatedWork W4361950893 @default.
- W4362545677 hasRelatedWork W4362545677 @default.
- W4362545677 isParatext "false" @default.
- W4362545677 isRetracted "false" @default.
- W4362545677 workType "article" @default.