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- W4362545687 abstract "<div>Abstract<p>CD8 T lymphocytes are able to eliminate nascent tumor cells through a process referred to as immunosurveillance. However, multiple inhibitory mechanisms within the tumor microenvironment have been described that impede tumor rejection by CD8 T cells, including increased signaling by inhibitory receptors. Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that has been shown repeatedly to promote diverse cellular processes benefiting tumorigenesis. Accordingly, the exaggerated expression of LPA and LPA receptors is a common feature of diverse tumor cell lineages and can result in elevated systemic LPA levels. LPA is recognized by at least six distinct G protein–coupled receptors, several of which are expressed by T cells, although the precise function of LPA signaling in CD8 T-cell activation and function has not been defined. Here, we show that LPA signaling via the LPA<sub>5</sub> receptor expressed by CD8 T cells suppresses antigen receptor signaling, cell activation, and proliferation <i>in vitro</i> and <i>in vivo</i>. Importantly, in a mouse melanoma model tumor-specific CD8 T cells that are LPA<sub>5</sub>-deficient are able to control tumor growth significantly better than wild-type tumor-specific CD8 T cells. Together, these data suggest that the production of LPA by tumors serves not only in an autocrine manner to promote tumorigenesis, but also as a mechanism to suppress adaptive immunity and highlights a potential novel target for cancer treatment. <i>Cancer Immunol Res; 1(4); 245–55. ©2013 AACR</i>.</p></div>" @default.
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- W4362545687 date "2023-04-03" @default.
- W4362545687 modified "2023-10-16" @default.
- W4362545687 title "Data from Lysophosphatidic Acid Inhibits CD8 T-cell Activation and Control of Tumor Progression" @default.
- W4362545687 doi "https://doi.org/10.1158/2326-6066.c.6548242.v1" @default.
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