FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362545743> ?p ?o ?g. }

• W4362545743 endingPage "784" @default.
• W4362545743 startingPage "784" @default.
• W4362545743 abstract "Abstract Background: Among the recently developed blood-based multi-cancer early detection (MCED) tests, determining the location of tumors is pivotal to guiding appropriate treatment. We aim to systematically review and statistically examine the accuracy of tumor of origin prediction among blood-based MCED tests. Methods: Original articles were searched from Pubmed, Cochrane, and Embase that featured blood-based screening tests, multiple cancer types, and asymptomatic human subjects. We excluded studies with small samples (n&lt;30), non-screening tests, and non-blood-based tests. For cell-free DNA (cfDNA) based assays, measurements of diagnostic accuracy were pooled for meta-analysis. Findings: Of 1,074 records identified and screened, 4 cohort studies were analyzed using cfDNA-based diagnostic tests. The accuracy of tissue-of-origin (TOO) prediction for 3,762 cancer samples across cancer types was 0.79 (95% CI 0.64 - 0.91). Among six cancer types, colorectal cancers had the highest accuracy, and liver & bile duct cancers had the lowest, although the difference was statistically insignificant (0.89 (95% CI 0.79-0.97) vs. 0.68 (95% CI 0.40-0.90)). Additionally, cases were most frequently misclassified as colorectal cancer (Table 1). Lastly, two studies reported increased prediction accuracies when two sites of origin were assigned rather than a single site. The information for localizing TOO was derived from methylation patterns of cfDNA in two studies, fragmentation profiles of cfDNA in another study, and protein markers in the other research. Interpretation: Our results demonstrate that the primary site of cancers was accurately discerned in 79% of cases by MCED tests. However, the performance varies across cancer types. Further research on performance according to cancer stages and in combination with other molecular profiling is warranted. Table 1. Events/Total Accuracy of prediction (95% CI) misclassification type freqeuncy Total 3,129/3,762 0.79 (0.64 - 0.91) Colorectal 638/723 0.89 (0.79 - 0.97) stomach & esophagus 26/553 breast 8/553 Breast 443/538 0.86 (0.64 - 0.99) colorectal 20/349 pancreas & GB 4/349 lung 4/349 Ovarian Breast 132/159 0.85 (0.62 - 0.99) colorectal 39/261 uterus 13/147 Pancreatic & GB 289/338 0.82 (0.69 - 0.93) colorectal 12/300 stomach & esophagus 10/300 Stomach & Esophagus 225/311 0.75 (0.48 - 0.95) colorectal 39/261 lung 10/261 Lung 530/656 0.72 (0.45 - 0.92) colorectal 29/560 head and neck 8/560 Liver & Bile duct 95/144 0.68 (0.40 - 0.90) colorectal 13/220 pancreatic & GB 8/220 Abbreviations: CI = confidence interval; GB = gallbladder Citation Format: Youjin Oh, Joo Hee Park, Liam Il-Young Chung, Richard Duan, Trie Arni Djunadi, Sung Mi Yoon, Zunairah Shah, Chan Mi Jung, Ilene Hong, Leeseul Kim, Horyun Choi, Young Kwang Chae. Systematic review and meta-analysis of the accuracy of tumor origin detection in blood-based multi-cancer early detection (MCED) in the general population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 784." @default.
• W4362545743 created "2023-04-06" @default.
• W4362545743 creator A5016413478 @default.
• W4362545743 creator A5019429740 @default.
• W4362545743 creator A5020509902 @default.
• W4362545743 creator A5025743931 @default.
• W4362545743 creator A5059817635 @default.
• W4362545743 creator A5062279447 @default.
• W4362545743 creator A5068906617 @default.
• W4362545743 creator A5075517933 @default.
• W4362545743 creator A5076579370 @default.
• W4362545743 creator A5081588858 @default.
• W4362545743 creator A5086703197 @default.
• W4362545743 creator A5088604504 @default.
• W4362545743 date "2023-04-04" @default.
• W4362545743 modified "2023-10-16" @default.
• W4362545743 title "Abstract 784: Systematic review and meta-analysis of the accuracy of tumor origin detection in blood-based multi-cancer early detection (MCED) in the general population" @default.
• W4362545743 doi "https://doi.org/10.1158/1538-7445.am2023-784" @default.
• W4362545743 hasPublicationYear "2023" @default.
• W4362545743 type Work @default.
• W4362545743 citedByCount "0" @default.
• W4362545743 crossrefType "journal-article" @default.
• W4362545743 hasAuthorship W4362545743A5016413478 @default.
• W4362545743 hasAuthorship W4362545743A5019429740 @default.
• W4362545743 hasAuthorship W4362545743A5020509902 @default.
• W4362545743 hasAuthorship W4362545743A5025743931 @default.
• W4362545743 hasAuthorship W4362545743A5059817635 @default.
• W4362545743 hasAuthorship W4362545743A5062279447 @default.
• W4362545743 hasAuthorship W4362545743A5068906617 @default.
• W4362545743 hasAuthorship W4362545743A5075517933 @default.
• W4362545743 hasAuthorship W4362545743A5076579370 @default.
• W4362545743 hasAuthorship W4362545743A5081588858 @default.
• W4362545743 hasAuthorship W4362545743A5086703197 @default.
• W4362545743 hasAuthorship W4362545743A5088604504 @default.
• W4362545743 hasConcept C121608353 @default.
• W4362545743 hasConcept C126322002 @default.
• W4362545743 hasConcept C142724271 @default.
• W4362545743 hasConcept C143998085 @default.
• W4362545743 hasConcept C2777910003 @default.
• W4362545743 hasConcept C2908647359 @default.
• W4362545743 hasConcept C526805850 @default.
• W4362545743 hasConcept C71924100 @default.
• W4362545743 hasConcept C95190672 @default.
• W4362545743 hasConcept C99454951 @default.
• W4362545743 hasConceptScore W4362545743C121608353 @default.
• W4362545743 hasConceptScore W4362545743C126322002 @default.
• W4362545743 hasConceptScore W4362545743C142724271 @default.
• W4362545743 hasConceptScore W4362545743C143998085 @default.
• W4362545743 hasConceptScore W4362545743C2777910003 @default.
• W4362545743 hasConceptScore W4362545743C2908647359 @default.
• W4362545743 hasConceptScore W4362545743C526805850 @default.
• W4362545743 hasConceptScore W4362545743C71924100 @default.
• W4362545743 hasConceptScore W4362545743C95190672 @default.
• W4362545743 hasConceptScore W4362545743C99454951 @default.
• W4362545743 hasIssue "7_Supplement" @default.
• W4362545743 hasLocation W43625457431 @default.
• W4362545743 hasOpenAccess W4362545743 @default.
• W4362545743 hasPrimaryLocation W43625457431 @default.
• W4362545743 hasRelatedWork W129423339 @default.
• W4362545743 hasRelatedWork W1987215768 @default.
• W4362545743 hasRelatedWork W1991129960 @default.
• W4362545743 hasRelatedWork W1995188757 @default.
• W4362545743 hasRelatedWork W2007817983 @default.
• W4362545743 hasRelatedWork W2016679923 @default.
• W4362545743 hasRelatedWork W2116001782 @default.
• W4362545743 hasRelatedWork W2943195325 @default.
• W4362545743 hasRelatedWork W4229900919 @default.
• W4362545743 hasRelatedWork W17604275 @default.
• W4362545743 hasVolume "83" @default.
• W4362545743 isParatext "false" @default.
• W4362545743 isRetracted "false" @default.
• W4362545743 workType "article" @default.