FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362545793> ?p ?o ?g. }

• W4362545793 abstract "<div>Abstract<p>Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as <i>ETO2–GLIS2</i>, are associated with acute megakaryoblastic or other myeloid leukemia subtypes in an age-dependent manner. Analysis of a novel inducible transgenic mouse model showed that <i>ETO2–GLIS2</i> expression in fetal hematopoietic stem cells induced rapid megakaryoblastic leukemia whereas expression in adult bone marrow hematopoietic stem cells resulted in a shift toward myeloid transformation with a strikingly delayed <i>in vivo</i> leukemogenic potential. Chromatin accessibility and single-cell transcriptome analyses indicate ontogeny-dependent intrinsic and <i>ETO2–GLIS2</i>-induced differences in the activities of key transcription factors, including ERG, SPI1, GATA1, and CEBPA. Importantly, switching off the fusion oncogene restored terminal differentiation of the leukemic blasts. Together, these data show that aggressiveness and phenotypes in pediatric acute myeloid leukemia result from an ontogeny-related differential susceptibility to transformation by fusion oncogenes.</p>Significance:<p>This work demonstrates that the clinical phenotype of pediatric acute myeloid leukemia is determined by ontogeny-dependent susceptibility for transformation by oncogenic fusion genes. The phenotype is maintained by potentially reversible alteration of key transcription factors, indicating that targeting of the fusions may overcome the differentiation blockage and revert the leukemic state.</p><p><i>See related commentary by Cruz Hernandez and Vyas, p. 1653</i>.</p><p><i>This article is highlighted in the In This Issue feature, p. 1631</i></p></div>" @default.
• W4362545793 created "2023-04-06" @default.
• W4362545793 creator A5001321701 @default.
• W4362545793 creator A5002530974 @default.
• W4362545793 creator A5008225883 @default.
• W4362545793 creator A5009884108 @default.
• W4362545793 creator A5012739035 @default.
• W4362545793 creator A5017318024 @default.
• W4362545793 creator A5022712318 @default.
• W4362545793 creator A5026484326 @default.
• W4362545793 creator A5027549836 @default.
• W4362545793 creator A5027733991 @default.
• W4362545793 creator A5030763668 @default.
• W4362545793 creator A5032250789 @default.
• W4362545793 creator A5037758030 @default.
• W4362545793 creator A5039169149 @default.
• W4362545793 creator A5040189113 @default.
• W4362545793 creator A5041817169 @default.
• W4362545793 creator A5042670578 @default.
• W4362545793 creator A5045088100 @default.
• W4362545793 creator A5048022687 @default.
• W4362545793 creator A5052460206 @default.
• W4362545793 creator A5053450483 @default.
• W4362545793 creator A5053896107 @default.
• W4362545793 creator A5057065832 @default.
• W4362545793 creator A5057574703 @default.
• W4362545793 creator A5057670341 @default.
• W4362545793 creator A5061199140 @default.
• W4362545793 creator A5062474897 @default.
• W4362545793 creator A5062652588 @default.
• W4362545793 creator A5064557037 @default.
• W4362545793 creator A5068555614 @default.
• W4362545793 creator A5075594149 @default.
• W4362545793 creator A5081008172 @default.
• W4362545793 creator A5082404845 @default.
• W4362545793 creator A5085851050 @default.
• W4362545793 creator A5091358858 @default.
• W4362545793 creator A5018438485 @default.
• W4362545793 date "2023-04-03" @default.
• W4362545793 modified "2023-10-17" @default.
• W4362545793 title "Data from Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene–Driven Myeloid Leukemia" @default.
• W4362545793 doi "https://doi.org/10.1158/2159-8290.c.6548296.v1" @default.
• W4362545793 hasPublicationYear "2023" @default.
• W4362545793 type Work @default.
• W4362545793 citedByCount "0" @default.
• W4362545793 crossrefType "posted-content" @default.
• W4362545793 hasAuthorship W4362545793A5001321701 @default.
• W4362545793 hasAuthorship W4362545793A5002530974 @default.
• W4362545793 hasAuthorship W4362545793A5008225883 @default.
• W4362545793 hasAuthorship W4362545793A5009884108 @default.
• W4362545793 hasAuthorship W4362545793A5012739035 @default.
• W4362545793 hasAuthorship W4362545793A5017318024 @default.
• W4362545793 hasAuthorship W4362545793A5018438485 @default.
• W4362545793 hasAuthorship W4362545793A5022712318 @default.
• W4362545793 hasAuthorship W4362545793A5026484326 @default.
• W4362545793 hasAuthorship W4362545793A5027549836 @default.
• W4362545793 hasAuthorship W4362545793A5027733991 @default.
• W4362545793 hasAuthorship W4362545793A5030763668 @default.
• W4362545793 hasAuthorship W4362545793A5032250789 @default.
• W4362545793 hasAuthorship W4362545793A5037758030 @default.
• W4362545793 hasAuthorship W4362545793A5039169149 @default.
• W4362545793 hasAuthorship W4362545793A5040189113 @default.
• W4362545793 hasAuthorship W4362545793A5041817169 @default.
• W4362545793 hasAuthorship W4362545793A5042670578 @default.
• W4362545793 hasAuthorship W4362545793A5045088100 @default.
• W4362545793 hasAuthorship W4362545793A5048022687 @default.
• W4362545793 hasAuthorship W4362545793A5052460206 @default.
• W4362545793 hasAuthorship W4362545793A5053450483 @default.
• W4362545793 hasAuthorship W4362545793A5053896107 @default.
• W4362545793 hasAuthorship W4362545793A5057065832 @default.
• W4362545793 hasAuthorship W4362545793A5057574703 @default.
• W4362545793 hasAuthorship W4362545793A5057670341 @default.
• W4362545793 hasAuthorship W4362545793A5061199140 @default.
• W4362545793 hasAuthorship W4362545793A5062474897 @default.
• W4362545793 hasAuthorship W4362545793A5062652588 @default.
• W4362545793 hasAuthorship W4362545793A5064557037 @default.
• W4362545793 hasAuthorship W4362545793A5068555614 @default.
• W4362545793 hasAuthorship W4362545793A5075594149 @default.
• W4362545793 hasAuthorship W4362545793A5081008172 @default.
• W4362545793 hasAuthorship W4362545793A5082404845 @default.
• W4362545793 hasAuthorship W4362545793A5085851050 @default.
• W4362545793 hasAuthorship W4362545793A5091358858 @default.
• W4362545793 hasConcept C104317684 @default.
• W4362545793 hasConcept C109159458 @default.
• W4362545793 hasConcept C111829193 @default.
• W4362545793 hasConcept C127716648 @default.
• W4362545793 hasConcept C1491633281 @default.
• W4362545793 hasConcept C165864922 @default.
• W4362545793 hasConcept C192196715 @default.
• W4362545793 hasConcept C203014093 @default.
• W4362545793 hasConcept C2778461978 @default.
• W4362545793 hasConcept C2778729363 @default.
• W4362545793 hasConcept C2779282312 @default.
• W4362545793 hasConcept C2781018059 @default.
• W4362545793 hasConcept C28328180 @default.
• W4362545793 hasConcept C2909762590 @default.
• W4362545793 hasConcept C29537977 @default.
• W4362545793 hasConcept C45091340 @default.
• W4362545793 hasConcept C502942594 @default.
• W4362545793 hasConcept C54355233 @default.

• next