Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362545806> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4362545806 abstract "<div>Abstract<p>The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. We previously established that an unidentified factor, or factors, present in ovarian tumor ascites fluids reversibly inhibited the activation of T cells by arresting the T-cell signaling cascade. Ultracentrifugation of the tumor ascites fluid has now revealed a pellet that contains small extracellular vesicles (EV) with an average diameter of 80 nm. The T-cell arrest was determined to be causally linked to phosphatidylserine (PS) that is present on the outer leaflet of the vesicle bilayer, as a depletion of PS-expressing EV or a blockade of PS with anti-PS antibody significantly inhibits the vesicle-induced signaling arrest. The inhibitory EV were also isolated from solid tumor tissues. The presence of immunosuppressive vesicles in the microenvironments of ovarian tumors and our ability to block their inhibition of T-cell function represent a potential therapeutic target for patients with ovarian cancer. <i>Cancer Immunol Res; 3(11); 1269–78. ©2015 AACR</i>.</p></div>" @default.
- W4362545806 created "2023-04-06" @default.
- W4362545806 creator A5009400324 @default.
- W4362545806 creator A5017993770 @default.
- W4362545806 creator A5032555898 @default.
- W4362545806 creator A5032763009 @default.
- W4362545806 creator A5036587808 @default.
- W4362545806 creator A5038411100 @default.
- W4362545806 creator A5041278737 @default.
- W4362545806 creator A5053524483 @default.
- W4362545806 creator A5053887896 @default.
- W4362545806 creator A5056250710 @default.
- W4362545806 creator A5061332222 @default.
- W4362545806 creator A5062601553 @default.
- W4362545806 creator A5065404552 @default.
- W4362545806 date "2023-04-03" @default.
- W4362545806 modified "2023-09-25" @default.
- W4362545806 title "Data from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade" @default.
- W4362545806 doi "https://doi.org/10.1158/2326-6066.c.6548428.v1" @default.
- W4362545806 hasPublicationYear "2023" @default.
- W4362545806 type Work @default.
- W4362545806 citedByCount "0" @default.
- W4362545806 crossrefType "posted-content" @default.
- W4362545806 hasAuthorship W4362545806A5009400324 @default.
- W4362545806 hasAuthorship W4362545806A5017993770 @default.
- W4362545806 hasAuthorship W4362545806A5032555898 @default.
- W4362545806 hasAuthorship W4362545806A5032763009 @default.
- W4362545806 hasAuthorship W4362545806A5036587808 @default.
- W4362545806 hasAuthorship W4362545806A5038411100 @default.
- W4362545806 hasAuthorship W4362545806A5041278737 @default.
- W4362545806 hasAuthorship W4362545806A5053524483 @default.
- W4362545806 hasAuthorship W4362545806A5053887896 @default.
- W4362545806 hasAuthorship W4362545806A5056250710 @default.
- W4362545806 hasAuthorship W4362545806A5061332222 @default.
- W4362545806 hasAuthorship W4362545806A5062601553 @default.
- W4362545806 hasAuthorship W4362545806A5065404552 @default.
- W4362545806 hasConcept C104317684 @default.
- W4362545806 hasConcept C130316041 @default.
- W4362545806 hasConcept C145059251 @default.
- W4362545806 hasConcept C1491633281 @default.
- W4362545806 hasConcept C185592680 @default.
- W4362545806 hasConcept C203014093 @default.
- W4362545806 hasConcept C20518536 @default.
- W4362545806 hasConcept C2778918659 @default.
- W4362545806 hasConcept C2779637612 @default.
- W4362545806 hasConcept C28406088 @default.
- W4362545806 hasConcept C2908689518 @default.
- W4362545806 hasConcept C41625074 @default.
- W4362545806 hasConcept C502942594 @default.
- W4362545806 hasConcept C55493867 @default.
- W4362545806 hasConcept C62478195 @default.
- W4362545806 hasConcept C86803240 @default.
- W4362545806 hasConcept C8891405 @default.
- W4362545806 hasConcept C95444343 @default.
- W4362545806 hasConceptScore W4362545806C104317684 @default.
- W4362545806 hasConceptScore W4362545806C130316041 @default.
- W4362545806 hasConceptScore W4362545806C145059251 @default.
- W4362545806 hasConceptScore W4362545806C1491633281 @default.
- W4362545806 hasConceptScore W4362545806C185592680 @default.
- W4362545806 hasConceptScore W4362545806C203014093 @default.
- W4362545806 hasConceptScore W4362545806C20518536 @default.
- W4362545806 hasConceptScore W4362545806C2778918659 @default.
- W4362545806 hasConceptScore W4362545806C2779637612 @default.
- W4362545806 hasConceptScore W4362545806C28406088 @default.
- W4362545806 hasConceptScore W4362545806C2908689518 @default.
- W4362545806 hasConceptScore W4362545806C41625074 @default.
- W4362545806 hasConceptScore W4362545806C502942594 @default.
- W4362545806 hasConceptScore W4362545806C55493867 @default.
- W4362545806 hasConceptScore W4362545806C62478195 @default.
- W4362545806 hasConceptScore W4362545806C86803240 @default.
- W4362545806 hasConceptScore W4362545806C8891405 @default.
- W4362545806 hasConceptScore W4362545806C95444343 @default.
- W4362545806 hasLocation W43625458061 @default.
- W4362545806 hasOpenAccess W4362545806 @default.
- W4362545806 hasPrimaryLocation W43625458061 @default.
- W4362545806 hasRelatedWork W1540690193 @default.
- W4362545806 hasRelatedWork W2417330625 @default.
- W4362545806 hasRelatedWork W2784634590 @default.
- W4362545806 hasRelatedWork W2808976093 @default.
- W4362545806 hasRelatedWork W2905073085 @default.
- W4362545806 hasRelatedWork W3029658651 @default.
- W4362545806 hasRelatedWork W3201588038 @default.
- W4362545806 hasRelatedWork W4311505397 @default.
- W4362545806 hasRelatedWork W4361199491 @default.
- W4362545806 hasRelatedWork W4362705409 @default.
- W4362545806 isParatext "false" @default.
- W4362545806 isRetracted "false" @default.
- W4362545806 workType "article" @default.