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- W4362545897 abstract "<div>Abstract<p>Adoptive transfer of T cells engineered to express chimeric immunoreceptors is an effective strategy to treat hematologic cancers; however, the use of this type of therapy for solid cancers, such as ovarian cancer, remains challenging because a safe and effective immunotherapeutic target has not yet been identified. Here, we constructed and evaluated a novel redirected T-cell–based immunotherapy targeting human follicle-stimulating hormone receptor (FSHR), a highly conserved molecule in vertebrate animals with expression limited to gonadal tissues, ovarian cancer, and cancer-associated vasculature. Receptor ligand–based anti-FSHR immunoreceptors were constructed that contained small binding fragments from the ligand for FSHR, FSH, fused to T-cell transmembrane and T-cell signaling domains. Human T cells transduced to express anti-FSHR immunoreceptors were specifically immunoreactive against FSHR-expressing human and mouse ovarian cancer cell lines in an MHC-nonrestricted manner and mediated effective lysis of FHSR-expressing tumor cells, but not FSHR-deficient targets, <i>in vitro</i>. Similarly, the outgrowth of human ovarian cancer xenografts in immunodeficient mice was significantly inhibited by the adoptive transfer of FSHR-redirected T cells. Our experimental observations show that FSHR is a promising immunotherapeutic target for ovarian cancer and support further exploration of FSHR-targeted immune therapy approaches for patients with cancer. <i>Cancer Immunol Res; 3(10); 1130–7. ©2015 AACR</i>.</p></div>" @default.
- W4362545897 created "2023-04-06" @default.
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- W4362545897 date "2023-04-03" @default.
- W4362545897 modified "2023-10-01" @default.
- W4362545897 title "Data from Follicle-Stimulating Hormone Receptor as a Target in the Redirected T-cell Therapy for Cancer" @default.
- W4362545897 doi "https://doi.org/10.1158/2326-6066.c.6548531.v1" @default.
- W4362545897 hasPublicationYear "2023" @default.
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