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- W4362546075 abstract "<div>Abstract<p>Head and neck squamous cell carcinoma (HNSCC) has been treated for decades with cisplatin chemotherapy, and anti–PD-1 immunotherapy has recently been approved for the treatment of this disease. However, preclinical studies of how antitumor immunity in HNSCC is affected by cisplatin alone or in combination with immunotherapies are lacking. Here, we show that sublethal doses of cisplatin may enhance antigen presentation and T-cell killing <i>in vitro</i>, though cisplatin also upregulates tumor cell expression of PD-L1 and may impair T-cell function at higher doses. In a syngeneic mouse model of HNSCC, concurrent use of cisplatin and anti–PD-L1/PD-1 delayed tumor growth and enhanced survival without significantly reducing the number or function of tumor-infiltrating immune cells or increasing cisplatin-induced toxicities. These results suggest that moderate doses of cisplatin may enhance antitumor immunity by mechanisms other than direct tumor cell killing, which may be further enhanced by anti–PD-L1/PD-1 therapy. <i>Cancer Immunol Res; 5(12); 1141–51. ©2017 AACR</i>.</p></div>" @default.
- W4362546075 created "2023-04-06" @default.
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- W4362546075 date "2023-04-03" @default.
- W4362546075 modified "2023-09-29" @default.
- W4362546075 title "Data from Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma" @default.
- W4362546075 doi "https://doi.org/10.1158/2326-6066.c.6548747.v1" @default.
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