Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362546355> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4362546355 abstract "<div>Abstract<p>Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-depleted tumor microenvironment, they can acquire nutrients via macropinocytosis, an endocytic form of protein scavenging that functions to support cancer metabolism. Here, we provide evidence that macropinocytosis is also operational in the pancreatic tumor stroma. We find that glutamine deficiency triggers macropinocytic uptake in pancreatic cancer–associated fibroblasts (CAF). Mechanistically, we decipher that stromal macropinocytosis is potentiated via the enhancement of cytosolic Ca<sup>2+</sup> and dependent on ARHGEF2 and CaMKK2-AMPK signaling. We elucidate that macropinocytosis has a dual function in CAFs—it serves as a source of intracellular amino acids that sustain CAF cell fitness and function, and it provides secreted amino acids that promote tumor cell survival. Importantly, we demonstrate that stromal macropinocytosis supports PDAC tumor growth. These results highlight the functional role of macropinocytosis in the tumor stroma and provide a mechanistic understanding of how nutrient deficiency can control stromal protein scavenging.</p>Significance:<p>Glutamine deprivation drives stromal macropinocytosis to support CAF cell fitness and provide amino acids that sustain PDAC cell survival. Selective disruption of macropinocytosis in CAFs suppresses PDAC tumor growth.</p><p><i>This article is highlighted in the In This Issue feature, p. 1601</i></p></div>" @default.
- W4362546355 created "2023-04-06" @default.
- W4362546355 creator A5008199007 @default.
- W4362546355 creator A5017746225 @default.
- W4362546355 creator A5019159624 @default.
- W4362546355 creator A5019530454 @default.
- W4362546355 creator A5064589097 @default.
- W4362546355 creator A5076460963 @default.
- W4362546355 creator A5078733977 @default.
- W4362546355 creator A5080326390 @default.
- W4362546355 creator A5089839809 @default.
- W4362546355 date "2023-04-03" @default.
- W4362546355 modified "2023-09-29" @default.
- W4362546355 title "Data from Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness" @default.
- W4362546355 doi "https://doi.org/10.1158/2159-8290.c.6549388.v1" @default.
- W4362546355 hasPublicationYear "2023" @default.
- W4362546355 type Work @default.
- W4362546355 citedByCount "0" @default.
- W4362546355 crossrefType "posted-content" @default.
- W4362546355 hasAuthorship W4362546355A5008199007 @default.
- W4362546355 hasAuthorship W4362546355A5017746225 @default.
- W4362546355 hasAuthorship W4362546355A5019159624 @default.
- W4362546355 hasAuthorship W4362546355A5019530454 @default.
- W4362546355 hasAuthorship W4362546355A5064589097 @default.
- W4362546355 hasAuthorship W4362546355A5076460963 @default.
- W4362546355 hasAuthorship W4362546355A5078733977 @default.
- W4362546355 hasAuthorship W4362546355A5080326390 @default.
- W4362546355 hasAuthorship W4362546355A5089839809 @default.
- W4362546355 hasBestOaLocation W43625463552 @default.
- W4362546355 hasConcept C121608353 @default.
- W4362546355 hasConcept C1491633281 @default.
- W4362546355 hasConcept C16930146 @default.
- W4362546355 hasConcept C185592680 @default.
- W4362546355 hasConcept C203014093 @default.
- W4362546355 hasConcept C204232928 @default.
- W4362546355 hasConcept C2776107976 @default.
- W4362546355 hasConcept C2779349466 @default.
- W4362546355 hasConcept C2780210213 @default.
- W4362546355 hasConcept C28005876 @default.
- W4362546355 hasConcept C3020616263 @default.
- W4362546355 hasConcept C40017333 @default.
- W4362546355 hasConcept C502942594 @default.
- W4362546355 hasConcept C515207424 @default.
- W4362546355 hasConcept C52124034 @default.
- W4362546355 hasConcept C54355233 @default.
- W4362546355 hasConcept C55493867 @default.
- W4362546355 hasConcept C86803240 @default.
- W4362546355 hasConcept C95444343 @default.
- W4362546355 hasConcept C96232424 @default.
- W4362546355 hasConceptScore W4362546355C121608353 @default.
- W4362546355 hasConceptScore W4362546355C1491633281 @default.
- W4362546355 hasConceptScore W4362546355C16930146 @default.
- W4362546355 hasConceptScore W4362546355C185592680 @default.
- W4362546355 hasConceptScore W4362546355C203014093 @default.
- W4362546355 hasConceptScore W4362546355C204232928 @default.
- W4362546355 hasConceptScore W4362546355C2776107976 @default.
- W4362546355 hasConceptScore W4362546355C2779349466 @default.
- W4362546355 hasConceptScore W4362546355C2780210213 @default.
- W4362546355 hasConceptScore W4362546355C28005876 @default.
- W4362546355 hasConceptScore W4362546355C3020616263 @default.
- W4362546355 hasConceptScore W4362546355C40017333 @default.
- W4362546355 hasConceptScore W4362546355C502942594 @default.
- W4362546355 hasConceptScore W4362546355C515207424 @default.
- W4362546355 hasConceptScore W4362546355C52124034 @default.
- W4362546355 hasConceptScore W4362546355C54355233 @default.
- W4362546355 hasConceptScore W4362546355C55493867 @default.
- W4362546355 hasConceptScore W4362546355C86803240 @default.
- W4362546355 hasConceptScore W4362546355C95444343 @default.
- W4362546355 hasConceptScore W4362546355C96232424 @default.
- W4362546355 hasLocation W43625463551 @default.
- W4362546355 hasLocation W43625463552 @default.
- W4362546355 hasOpenAccess W4362546355 @default.
- W4362546355 hasPrimaryLocation W43625463551 @default.
- W4362546355 hasRelatedWork W2111520856 @default.
- W4362546355 hasRelatedWork W2220916195 @default.
- W4362546355 hasRelatedWork W2561583042 @default.
- W4362546355 hasRelatedWork W2600123923 @default.
- W4362546355 hasRelatedWork W2615907953 @default.
- W4362546355 hasRelatedWork W2901891025 @default.
- W4362546355 hasRelatedWork W2909528400 @default.
- W4362546355 hasRelatedWork W3017611767 @default.
- W4362546355 hasRelatedWork W427389120 @default.
- W4362546355 hasRelatedWork W4296160394 @default.
- W4362546355 isParatext "false" @default.
- W4362546355 isRetracted "false" @default.
- W4362546355 workType "article" @default.