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• W4362546640 abstract "<div>Abstract<p>Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4⁺ T cells (T_FH) are among the best therapeutic targets of pembrolizumab correlating with progression-free survival. T_FH were associated with tumoral CD8 and PD-L1 expression at baseline and the induction of tertiary lymphoid structures after pembrolizumab. Blood central memory T_FH accumulated in tumors where they produce CXCL13, a chemokine found in the plasma of responders only. IgG4⁺CD38⁺ T_FH residing in bladder tissues correlated with clinical benefit. Finally, T_FH and IgG directed against urothelium-invasive <i>Escherichia coli</i> dictated clinical responses to pembrolizumab in three independent cohorts. The links between tumor infection and success of ICB immunomodulation should be prospectively assessed at a larger scale.</p>Significance:<p>In patients with bladder cancer treated with neoadjuvant pembrolizumab, <i>E. coli</i>–specific CXCL13 producing T_FH and IgG constitute biomarkers that predict clinical benefit. Beyond its role as a biomarker, such immune responses against <i>E. coli</i> might be harnessed for future therapeutic strategies.</p><p><i><a href=https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-12-10-ITI target=_blank>This article is highlighted in the In This Issue feature, p. 2221</a></i></p></div>" @default.
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• W4362546640 date "2023-04-04" @default.
• W4362546640 modified "2023-10-17" @default.
• W4362546640 title "Data from <i>Escherichia coli</i>–Specific CXCL13-Producing T_FH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer" @default.
• W4362546640 doi "https://doi.org/10.1158/2159-8290.c.6549753.v1" @default.
• W4362546640 hasPublicationYear "2023" @default.
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