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- W4362548683 abstract "<p>Supplementary Fig. S1. Basally expressed p53 may have important tumor suppressor targets. Supplementary Fig. S2. Binding targets of basal p53 in MCF10A cells. Supplementary Fig. S3. Exploring the binding targets of basal p53. Supplementary Fig. S4. Wild-type p53 maintains expression of tumor suppressor target genes. Supplementary Fig. S5. Long range chromatin interactions of enhancers with transcriptional start sites of basal p53 targets. Supplementary Fig. S6. Enhancer for PTEN is present in multiple cell types. Supplementary Fig. S7. The binding and regulation of the PTEN locus by basal p53. Supplementary Fig. S8. PTEN-eP53RE is a highly conserved p53 response element in a p53-dependent enhancer. Supplementary Fig. S9. Deletion of endogenous PTEN-eP53RE by CRISPR/Cas9. Supplementary Fig. S10. Depletion of p53 causes a PTEN-eP53RE-dependent decrease in PTEN expression, deletion of PTEN-eP53RE alters some tumor cell phenotypes. Supplementary Table S1. Information on tumor suppressor genes identified as basal p53 targets. Supplementary Table S2. Predicted p53 response elements within basal p53 binding sites using JASPAR. Supplementary Table S3. Chromatin properties of basal p53 binding sites near tumor suppressor genes. Legends for Supplementary Spreadsheets S1-S5. Additional Materials and Methods. References for Supplementary Material.</p>" @default.
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- W4362548683 date "2023-04-03" @default.
- W4362548683 modified "2023-10-16" @default.
- W4362548683 title "Supplementary Data for Article from p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes" @default.
- W4362548683 doi "https://doi.org/10.1158/1541-7786.22516218" @default.
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