Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362551930> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4362551930 abstract "<div>Abstract<p>Despite the great success of chimeric antigen receptor T (CAR-T)–cell therapy in the treatment of hematologic malignancies, CAR-T–cell therapy is limited in solid tumors, including hepatocellular carcinoma (HCC). NK group 2 member D (NKG2D) ligands (NKG2DL) are generally absent on the surface of normal cells but are overexpressed on malignant cells, offering good targets for CAR-T therapy. Indeed, analysis of The Cancer Genome Atlas and HCC tumor samples showed that the expression of most NKG2DLs was elevated in tumors compared with normal tissues. Thus, we designed a novel NKG2D-based CAR comprising the extracellular domain of human NKG2D, 4-1BB, and CD3ζ signaling domains (BBz). NKG2D-BBz CAR-T cells efficiently killed the HCC cell lines SMMC-7721 and MHCC97H <i>in vitro</i>, which express high levels of NKG2DLs, whereas they less efficiently killed NKG2DL-silenced SMMC-7721 cells or NKG2DL-negative Hep3B cells. Overexpression of MICA or ULBP2 in Hep3B improved the killing capacity of NKG2D-BBz CAR-T cells. T cells expressing the NKG2D-BBz CAR effectively eradicated SMMC-7721 HCC xenografts. Collectively, these results suggested that NKG2D-BBz CAR-T cells could potently eliminate NKG2DL-high HCC cells both <i>in vitro</i> and <i>in vivo</i>, thereby providing a promising therapeutic intervention for patients with NKG2DL-positive HCC.</p></div>" @default.
- W4362551930 created "2023-04-06" @default.
- W4362551930 creator A5000218861 @default.
- W4362551930 creator A5005417437 @default.
- W4362551930 creator A5034135434 @default.
- W4362551930 creator A5034185042 @default.
- W4362551930 creator A5070683894 @default.
- W4362551930 creator A5071278984 @default.
- W4362551930 creator A5073138170 @default.
- W4362551930 creator A5082953437 @default.
- W4362551930 creator A5083349103 @default.
- W4362551930 creator A5084956861 @default.
- W4362551930 date "2023-04-04" @default.
- W4362551930 modified "2023-10-18" @default.
- W4362551930 title "Data from Eradication of Hepatocellular Carcinoma by NKG2D-Based CAR-T Cells" @default.
- W4362551930 doi "https://doi.org/10.1158/2326-6066.c.6549807" @default.
- W4362551930 hasPublicationYear "2023" @default.
- W4362551930 type Work @default.
- W4362551930 citedByCount "0" @default.
- W4362551930 crossrefType "posted-content" @default.
- W4362551930 hasAuthorship W4362551930A5000218861 @default.
- W4362551930 hasAuthorship W4362551930A5005417437 @default.
- W4362551930 hasAuthorship W4362551930A5034135434 @default.
- W4362551930 hasAuthorship W4362551930A5034185042 @default.
- W4362551930 hasAuthorship W4362551930A5070683894 @default.
- W4362551930 hasAuthorship W4362551930A5071278984 @default.
- W4362551930 hasAuthorship W4362551930A5073138170 @default.
- W4362551930 hasAuthorship W4362551930A5082953437 @default.
- W4362551930 hasAuthorship W4362551930A5083349103 @default.
- W4362551930 hasAuthorship W4362551930A5084956861 @default.
- W4362551930 hasConcept C121608353 @default.
- W4362551930 hasConcept C126322002 @default.
- W4362551930 hasConcept C147483822 @default.
- W4362551930 hasConcept C1491633281 @default.
- W4362551930 hasConcept C154317977 @default.
- W4362551930 hasConcept C167672396 @default.
- W4362551930 hasConcept C202751555 @default.
- W4362551930 hasConcept C203014093 @default.
- W4362551930 hasConcept C2777701055 @default.
- W4362551930 hasConcept C2778019345 @default.
- W4362551930 hasConcept C2778867473 @default.
- W4362551930 hasConcept C3875195 @default.
- W4362551930 hasConcept C502942594 @default.
- W4362551930 hasConcept C54355233 @default.
- W4362551930 hasConcept C55493867 @default.
- W4362551930 hasConcept C71924100 @default.
- W4362551930 hasConcept C86803240 @default.
- W4362551930 hasConceptScore W4362551930C121608353 @default.
- W4362551930 hasConceptScore W4362551930C126322002 @default.
- W4362551930 hasConceptScore W4362551930C147483822 @default.
- W4362551930 hasConceptScore W4362551930C1491633281 @default.
- W4362551930 hasConceptScore W4362551930C154317977 @default.
- W4362551930 hasConceptScore W4362551930C167672396 @default.
- W4362551930 hasConceptScore W4362551930C202751555 @default.
- W4362551930 hasConceptScore W4362551930C203014093 @default.
- W4362551930 hasConceptScore W4362551930C2777701055 @default.
- W4362551930 hasConceptScore W4362551930C2778019345 @default.
- W4362551930 hasConceptScore W4362551930C2778867473 @default.
- W4362551930 hasConceptScore W4362551930C3875195 @default.
- W4362551930 hasConceptScore W4362551930C502942594 @default.
- W4362551930 hasConceptScore W4362551930C54355233 @default.
- W4362551930 hasConceptScore W4362551930C55493867 @default.
- W4362551930 hasConceptScore W4362551930C71924100 @default.
- W4362551930 hasConceptScore W4362551930C86803240 @default.
- W4362551930 hasLocation W43625519301 @default.
- W4362551930 hasOpenAccess W4362551930 @default.
- W4362551930 hasPrimaryLocation W43625519301 @default.
- W4362551930 hasRelatedWork W2052090039 @default.
- W4362551930 hasRelatedWork W2094678609 @default.
- W4362551930 hasRelatedWork W2112065900 @default.
- W4362551930 hasRelatedWork W2120341761 @default.
- W4362551930 hasRelatedWork W2797245267 @default.
- W4362551930 hasRelatedWork W2910109098 @default.
- W4362551930 hasRelatedWork W3011804615 @default.
- W4362551930 hasRelatedWork W3199043263 @default.
- W4362551930 hasRelatedWork W4362546728 @default.
- W4362551930 hasRelatedWork W4362552035 @default.
- W4362551930 isParatext "false" @default.
- W4362551930 isRetracted "false" @default.
- W4362551930 workType "article" @default.