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• W4362554310 abstract "We would like to thank 2. Burke J. et al. The retinal contribution to the kidney–brain axis in severe malaria. Trends Parasitol. 2023; 39: 410-411 Abstract Full Text Full Text PDF Scopus (1) Google Scholar for their interest in our article on the brain–kidney axis in severe malaria [ 1. Conroy A.L. et al. The kidney–brain pathogenic axis in severe falciparum malaria. Trends Parasitol. 2023; 39: 191-199 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar ] and for outlining the striking similarities between the kidney and the eye in terms of blood supply and vulnerability to microvascular disease [ 2. Burke J. et al. The retinal contribution to the kidney–brain axis in severe malaria. Trends Parasitol. 2023; 39: 410-411 Abstract Full Text Full Text PDF Scopus (1) Google Scholar ]. As studies have shown that the retina is a window to the pathological changes in the brain of children with cerebral malaria [ 3. Maude R.J. et al. The eye in cerebral malaria: what can it teach us?. Trans. R. Soc. Trop. Med. Hyg. 2009; 103: 661-664 Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar ], retinal investigations are a powerful tool that should be leveraged when evaluating the kidney–brain axis. The kidney–brain pathogenic axis in severe falciparum malariaConroy et al.Trends in ParasitologyFebruary 1, 2023In BriefDespite recent efforts and successes in reducing the malaria burden globally, severe P. falciparum infection still accounted for the vast majority of the reported 619 000 malaria deaths in 2021 [1]. In addition to this staggering death toll, severe malaria is a leading cause of acquired neurodisability (see Glossary) in African children [2]. These long-term effects were long believed to be confined to patients recovering from cerebral malaria, a neurological syndrome characterized by unrousable coma and leading to a constellation of persistent neurological sequelae in up to 30% of pediatric survivors, which include cognitive impairment, motor skills, visual coordination, seizures and attention deficit hyperactivity disorder [2,3]. Full-Text PDF Open AccessThe retinal contribution to the kidney–brain axis in severe malariaBurke et al.Trends in ParasitologyMarch 22, 2023In BriefWe commend Conroy et al. for their detailed review of anatomical, physiological, and clinical associations between the renal and central nervous systems in severe Plasmodium falciparum malaria [1]. Severe malaria has a substantial impact on the brain, and an underappreciated effect on the kidney that may influence the risk of future chronic kidney disease (CKD). Kidney disease is a major global health concern, and the interrelationship between these organs suggests exciting opportunities for malaria biomarkers and new therapies [1]. Full-Text PDF" @default.
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• W4362554310 date "2023-06-01" @default.
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• W4362554310 title "The brain–kidney–retinal axis in severe falciparum malaria" @default.
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• W4362554310 doi "https://doi.org/10.1016/j.pt.2023.03.014" @default.
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