Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362555402> ?p ?o ?g. }
- W4362555402 abstract "Abstract Background Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, the emphasis has recently been switched toward innovative techniques for modulating the immune response against tumors and their microenvironments (TME). Cancerous cells have eleven hallmarks which make it distinct from normal ones, among which is immune evasion. Immune evasion in glioblastoma helps it evade various treatment modalities. Summary Glioblastoma’s TME is composed of various array of cellular actors, ranging from peripherally derived immune cells to a variety of organ-resident specialized cell types. For example, the blood–brain barrier (BBB) serves as a selective barrier between the systemic circulation and the brain, which effectively separates it from other tissues. It is capable of blocking around 98% of molecules that transport different medications to the target tumor. Objectives The purpose of this paper is to offer a concise overview of fundamental immunology and how ‘clever’ gliomas avoid the immune system despite the discovery of immunotherapy for glioma. Conclusions Herein, we highlight the complex interplay of the tumor, the TME, and the nearby normal structures makes it difficult to grasp how to approach the tumor itself. Numerous researchers have found that the brain TME is a critical regulator of glioma growth and treatment efficacy." @default.
- W4362555402 created "2023-04-06" @default.
- W4362555402 creator A5014290200 @default.
- W4362555402 creator A5030335747 @default.
- W4362555402 creator A5038573046 @default.
- W4362555402 creator A5046740848 @default.
- W4362555402 creator A5064690618 @default.
- W4362555402 creator A5072695008 @default.
- W4362555402 creator A5078228633 @default.
- W4362555402 date "2023-03-30" @default.
- W4362555402 modified "2023-10-02" @default.
- W4362555402 title "Emerging hallmark of gliomas microenvironment in evading immunity: a basic concept" @default.
- W4362555402 cites W1019458012 @default.
- W4362555402 cites W1506672302 @default.
- W4362555402 cites W1510234358 @default.
- W4362555402 cites W1521600055 @default.
- W4362555402 cites W1579010799 @default.
- W4362555402 cites W1685239234 @default.
- W4362555402 cites W1815157104 @default.
- W4362555402 cites W181785431 @default.
- W4362555402 cites W1891618255 @default.
- W4362555402 cites W1942388905 @default.
- W4362555402 cites W1957113176 @default.
- W4362555402 cites W1962132325 @default.
- W4362555402 cites W1967797132 @default.
- W4362555402 cites W1977257270 @default.
- W4362555402 cites W1978495907 @default.
- W4362555402 cites W1978903184 @default.
- W4362555402 cites W1979038308 @default.
- W4362555402 cites W1980485314 @default.
- W4362555402 cites W1981256215 @default.
- W4362555402 cites W1982680586 @default.
- W4362555402 cites W1983768225 @default.
- W4362555402 cites W1987313116 @default.
- W4362555402 cites W1991464867 @default.
- W4362555402 cites W1992560794 @default.
- W4362555402 cites W1992883702 @default.
- W4362555402 cites W1997237161 @default.
- W4362555402 cites W1998952160 @default.
- W4362555402 cites W2011642035 @default.
- W4362555402 cites W2016671320 @default.
- W4362555402 cites W2016789384 @default.
- W4362555402 cites W2016883314 @default.
- W4362555402 cites W2024068846 @default.
- W4362555402 cites W2030166611 @default.
- W4362555402 cites W2033401119 @default.
- W4362555402 cites W2034269086 @default.
- W4362555402 cites W2034807686 @default.
- W4362555402 cites W2035437489 @default.
- W4362555402 cites W2035833975 @default.
- W4362555402 cites W2040374436 @default.
- W4362555402 cites W2040773741 @default.
- W4362555402 cites W2043702724 @default.
- W4362555402 cites W2044868069 @default.
- W4362555402 cites W2050175807 @default.
- W4362555402 cites W2052775433 @default.
- W4362555402 cites W2054917860 @default.
- W4362555402 cites W2062254683 @default.
- W4362555402 cites W2062936534 @default.
- W4362555402 cites W2063966481 @default.
- W4362555402 cites W2077215378 @default.
- W4362555402 cites W2077301497 @default.
- W4362555402 cites W2081845571 @default.
- W4362555402 cites W2083599957 @default.
- W4362555402 cites W2085099489 @default.
- W4362555402 cites W2086014809 @default.
- W4362555402 cites W2089187782 @default.
- W4362555402 cites W2095455162 @default.
- W4362555402 cites W2095593631 @default.
- W4362555402 cites W2096625946 @default.
- W4362555402 cites W2100213659 @default.
- W4362555402 cites W2101230909 @default.
- W4362555402 cites W2102870637 @default.
- W4362555402 cites W2106328748 @default.
- W4362555402 cites W2110956546 @default.
- W4362555402 cites W2114108194 @default.
- W4362555402 cites W2114701172 @default.
- W4362555402 cites W2117692326 @default.
- W4362555402 cites W2117728670 @default.
- W4362555402 cites W2125411036 @default.
- W4362555402 cites W2125493895 @default.
- W4362555402 cites W2125521995 @default.
- W4362555402 cites W2131495509 @default.
- W4362555402 cites W2132143019 @default.
- W4362555402 cites W2134638467 @default.
- W4362555402 cites W2135465849 @default.
- W4362555402 cites W2138217326 @default.
- W4362555402 cites W2138872728 @default.
- W4362555402 cites W2139047992 @default.
- W4362555402 cites W2140053672 @default.
- W4362555402 cites W2140380746 @default.
- W4362555402 cites W2142242761 @default.
- W4362555402 cites W2143021530 @default.
- W4362555402 cites W2143467222 @default.
- W4362555402 cites W2146934919 @default.
- W4362555402 cites W2148898943 @default.
- W4362555402 cites W2149123553 @default.
- W4362555402 cites W2150319141 @default.
- W4362555402 cites W2150492554 @default.
- W4362555402 cites W2150678612 @default.