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- W4362556545 abstract "Abstract Nintedanib, a potent, oral, small‐molecule tyrosine kinase inhibitor, is known as a triple angiokinase inhibitor, inhibiting three major signaling pathways in angiogenesis. Here, we report full details of the alternative path toward the synthesis of nintedanib via novel intermediates. A key feature of our approach is the stereoselective intramolecular cyclization strategy that enables the concise conversion of β‐keto amide into a 3‐acyloxindole derivative, which is an important scaffold for nintedanib synthesis. Subsequent condensation of oxindole scaffold with synthesized amine derivative led to the drug nintedanib with good yields." @default.
- W4362556545 created "2023-04-06" @default.
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- W4362556545 date "2023-04-04" @default.
- W4362556545 modified "2023-10-16" @default.
- W4362556545 title "An Efficient Approach Towards the Synthesis of Nintedanib" @default.
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- W4362556545 doi "https://doi.org/10.1002/slct.202300968" @default.
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