FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362557777> ?p ?o ?g. }

• W4362557777 abstract "<div>Abstract<p>Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized the polarity and specificity of memory T cells directed against SARS-CoV-2 viral lysates and peptides to determine correlates with spontaneous, virus-elicited, or vaccine-induced protection against COVID-19 in disease-free and cancer-bearing individuals. A disbalance between type 1 and 2 cytokine release was associated with high susceptibility to COVID-19. Individuals susceptible to infection exhibited a specific deficit in the T helper 1/T cytotoxic 1 (Th1/Tc1) peptide repertoire affecting the receptor binding domain of the spike protein (S1-RBD), a hotspot of viral mutations. Current vaccines triggered Th1/Tc1 responses in only a fraction of all subject categories, more effectively against the original sequence of S1-RBD than that from viral variants. We speculate that the next generation of vaccines should elicit Th1/Tc1 T-cell responses against the S1-RBD domain of emerging viral variants.</p>Significance:<p>This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike.</p><p><i>See related commentary by McGary and Vardhana, p. 892</i>.</p><p><i>This article is highlighted in the In This Issue feature, p. 873</i></p></div>" @default.
• W4362557777 created "2023-04-06" @default.
• W4362557777 creator A5000473619 @default.
• W4362557777 creator A5003527296 @default.
• W4362557777 creator A5003970424 @default.
• W4362557777 creator A5004527126 @default.
• W4362557777 creator A5004581254 @default.
• W4362557777 creator A5005440958 @default.
• W4362557777 creator A5006698445 @default.
• W4362557777 creator A5007024902 @default.
• W4362557777 creator A5014829112 @default.
• W4362557777 creator A5017657842 @default.
• W4362557777 creator A5018415934 @default.
• W4362557777 creator A5018632246 @default.
• W4362557777 creator A5020234871 @default.
• W4362557777 creator A5020254907 @default.
• W4362557777 creator A5021624793 @default.
• W4362557777 creator A5023057148 @default.
• W4362557777 creator A5023204629 @default.
• W4362557777 creator A5024365532 @default.
• W4362557777 creator A5027757914 @default.
• W4362557777 creator A5033918140 @default.
• W4362557777 creator A5035849206 @default.
• W4362557777 creator A5039469080 @default.
• W4362557777 creator A5039787537 @default.
• W4362557777 creator A5040803542 @default.
• W4362557777 creator A5042202815 @default.
• W4362557777 creator A5042535284 @default.
• W4362557777 creator A5043754495 @default.
• W4362557777 creator A5046220787 @default.
• W4362557777 creator A5050174167 @default.
• W4362557777 creator A5050608357 @default.
• W4362557777 creator A5051158823 @default.
• W4362557777 creator A5051834284 @default.
• W4362557777 creator A5053965677 @default.
• W4362557777 creator A5054491406 @default.
• W4362557777 creator A5056844302 @default.
• W4362557777 creator A5057390735 @default.
• W4362557777 creator A5058986182 @default.
• W4362557777 creator A5060218536 @default.
• W4362557777 creator A5060675099 @default.
• W4362557777 creator A5063565156 @default.
• W4362557777 creator A5064217794 @default.
• W4362557777 creator A5065206480 @default.
• W4362557777 creator A5066802725 @default.
• W4362557777 creator A5069099276 @default.
• W4362557777 creator A5069333253 @default.
• W4362557777 creator A5070354041 @default.
• W4362557777 creator A5071204291 @default.
• W4362557777 creator A5071855898 @default.
• W4362557777 creator A5072668656 @default.
• W4362557777 creator A5073457558 @default.
• W4362557777 creator A5074612242 @default.
• W4362557777 creator A5075149752 @default.
• W4362557777 creator A5075296559 @default.
• W4362557777 creator A5078781593 @default.
• W4362557777 creator A5079074289 @default.
• W4362557777 creator A5079807284 @default.
• W4362557777 creator A5082334341 @default.
• W4362557777 creator A5082847839 @default.
• W4362557777 creator A5084289930 @default.
• W4362557777 creator A5087836238 @default.
• W4362557777 creator A5088288683 @default.
• W4362557777 creator A5089473766 @default.
• W4362557777 creator A5089567534 @default.
• W4362557777 creator A5089810939 @default.
• W4362557777 creator A5089925930 @default.
• W4362557777 creator A5090249273 @default.
• W4362557777 creator A5091358858 @default.
• W4362557777 date "2023-04-04" @default.
• W4362557777 modified "2023-10-17" @default.
• W4362557777 title "Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals" @default.
• W4362557777 doi "https://doi.org/10.1158/2159-8290.c.6549506" @default.
• W4362557777 hasPublicationYear "2023" @default.
• W4362557777 type Work @default.
• W4362557777 citedByCount "0" @default.
• W4362557777 crossrefType "posted-content" @default.
• W4362557777 hasAuthorship W4362557777A5000473619 @default.
• W4362557777 hasAuthorship W4362557777A5003527296 @default.
• W4362557777 hasAuthorship W4362557777A5003970424 @default.
• W4362557777 hasAuthorship W4362557777A5004527126 @default.
• W4362557777 hasAuthorship W4362557777A5004581254 @default.
• W4362557777 hasAuthorship W4362557777A5005440958 @default.
• W4362557777 hasAuthorship W4362557777A5006698445 @default.
• W4362557777 hasAuthorship W4362557777A5007024902 @default.
• W4362557777 hasAuthorship W4362557777A5014829112 @default.
• W4362557777 hasAuthorship W4362557777A5017657842 @default.
• W4362557777 hasAuthorship W4362557777A5018415934 @default.
• W4362557777 hasAuthorship W4362557777A5018632246 @default.
• W4362557777 hasAuthorship W4362557777A5020234871 @default.
• W4362557777 hasAuthorship W4362557777A5020254907 @default.
• W4362557777 hasAuthorship W4362557777A5021624793 @default.
• W4362557777 hasAuthorship W4362557777A5023057148 @default.
• W4362557777 hasAuthorship W4362557777A5023204629 @default.
• W4362557777 hasAuthorship W4362557777A5024365532 @default.
• W4362557777 hasAuthorship W4362557777A5027757914 @default.
• W4362557777 hasAuthorship W4362557777A5033918140 @default.
• W4362557777 hasAuthorship W4362557777A5035849206 @default.
• W4362557777 hasAuthorship W4362557777A5039469080 @default.
• W4362557777 hasAuthorship W4362557777A5039787537 @default.

• next