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- W4362559429 abstract "Hepatocellular carcinoma (HCC) is a common malignant tumor with high incidence and cancer mortality worldwide. Post-translational modifications (PTMs) of proteins have a great impact on protein function. Almost all proteins can undergo PTMs, including phosphorylation, acetylation, methylation, glycosylation, ubiquitination, and so on. Many studies have shown that PTMs are related to the occurrence and development of cancers. The findings provide novel therapeutic targets for cancers, such as glypican-3 and mucin-1. Other clinical implications are also found in the studies of PTMs. Diagnostic or prognostic value, and response to therapy have been identified. In HCC, it has been shown that glycosylated alpha-fetoprotein (AFP) has a higher detection rate for early liver cancer than conventional AFP. In this review, we mainly focused on the diagnostic and prognostic value of PTM, in order to provide new insights into the clinical implication of PTM in HCC." @default.
- W4362559429 created "2023-04-06" @default.
- W4362559429 creator A5004747297 @default.
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- W4362559429 creator A5046418414 @default.
- W4362559429 creator A5080679237 @default.
- W4362559429 date "2023-04-04" @default.
- W4362559429 modified "2023-09-30" @default.
- W4362559429 title "Diagnostic and Prognostic Value of Protein Post-Translational Modifications in Hepatocellular Carcinoma" @default.
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