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• W4362559726 abstract "<p>CPI efficacy in EMT6 STK11wt, KO, and KO/KI tumors. (A) Western blotting of STK11, phosphorylated AMPK (p-AMPK), total AMPK, and actin in lysates from wild-type EMT6 cells (EMT6 WT), STK11 CRISPR KO clone (EMT6 KO) and from STK11 KO clone engineered to re-express STK11 (EMT6 STK11 KO/KI). The ratio of phosphorylated AMPK to total AMPK (p-AMPK/total AMPK) is shown at bottom. (B) Percentage of Ly6G+ granulocytic cells among CD45+ immune cells from EMT6 WT and EMT6 STK11 KO tumors determined by flow cytometry. Survival of mice engrafted with (C) EMT6 WT, (D) EMT6 STK11 KO clone or (E) EMT6 STK11 KO clone engineered to re-express STK11 (EMT6 STK11 KO/KI) and treated with combined CPI therapy. Survival of mice engrafted with (F) EMT6 WT or (G) EMT6 STK11 KO clone 26C43 and treated with STAT3 ASO, CPI immunotherapy, or STAT3 ASO plus CPI combinations as indicated.</p>" @default.
• W4362559726 created "2023-04-06" @default.
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• W4362559726 date "2023-04-03" @default.
• W4362559726 modified "2023-10-18" @default.
• W4362559726 title "Supplementary Figure S9 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown" @default.
• W4362559726 doi "https://doi.org/10.1158/2159-8290.22540409" @default.
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