Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362567099> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4362567099 abstract "<div>Abstract<p>Evidence suggests a relationship between dietary fat intake, obesity, and colorectal cancer, implying a role for fatty acid metabolism in intestinal tumorigenesis that is incompletely understood. Liver fatty acid-binding protein (L-Fabp), a dominant intestinal fatty acid-binding protein, regulates intestinal fatty acid trafficking and metabolism, and <i>L-Fabp</i> deletion attenuates diet-induced obesity. Here, we examined whether changes in intestinal fatty acid metabolism following <i>L-Fabp</i> deletion modify adenoma development in <i>Apc<sup>Min</sup></i><sup>/+</sup> mice. Compound <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice were generated and fed a 10% fat diet balanced equally between saturated, monounsaturated, and polyunsaturated fat. <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice displayed significant reductions in adenoma number and total polyp area compared with <i>Apc<sup>Min</sup></i><sup>/+</sup>controls, reflecting a significant shift in distribution toward smaller polyps. Adenomas from <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice exhibited reductions in cellular proliferation, high-grade dysplasia, and nuclear β-catenin translocation. Intestinal fatty acid content was increased in <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice, and lipidomic profiling of intestinal mucosa revealed significant shifts to polyunsaturated fatty acid species with reduced saturated fatty acid species. <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice also showed corresponding changes in mRNA expression of enzymes involved in fatty acid elongation and desaturation. Furthermore, adenomas from <i>L-Fabp</i><sup>−/−</sup><i>Apc<sup>Min</sup></i><sup>/+</sup> mice displayed significant reductions in mRNA abundance of nuclear hormone receptors involved in cellular proliferation and in enzymes involved in lipogenesis. These findings collectively implicate L-Fabp as an important genetic modifier of intestinal tumorigenesis, and identify fatty acid trafficking and metabolic compartmentalization as an important pathway linking dietary fat intake, obesity, and intestinal tumor formation. <i>Cancer Prev Res; 6(10); 1026–37. ©2013 AACR</i>.</p></div>" @default.
- W4362567099 created "2023-04-06" @default.
- W4362567099 creator A5006049004 @default.
- W4362567099 creator A5007616119 @default.
- W4362567099 creator A5023095216 @default.
- W4362567099 creator A5028307612 @default.
- W4362567099 creator A5042532963 @default.
- W4362567099 creator A5044034428 @default.
- W4362567099 creator A5045377550 @default.
- W4362567099 creator A5047287901 @default.
- W4362567099 creator A5051401435 @default.
- W4362567099 creator A5055755196 @default.
- W4362567099 creator A5081887769 @default.
- W4362567099 creator A5085343869 @default.
- W4362567099 date "2023-04-03" @default.
- W4362567099 modified "2023-09-28" @default.
- W4362567099 title "Data from Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in <i>Apc<sup>Min</sup></i><sup>/+</sup> Mice" @default.
- W4362567099 doi "https://doi.org/10.1158/1940-6207.c.6544842" @default.
- W4362567099 hasPublicationYear "2023" @default.
- W4362567099 type Work @default.
- W4362567099 citedByCount "0" @default.
- W4362567099 crossrefType "posted-content" @default.
- W4362567099 hasAuthorship W4362567099A5006049004 @default.
- W4362567099 hasAuthorship W4362567099A5007616119 @default.
- W4362567099 hasAuthorship W4362567099A5023095216 @default.
- W4362567099 hasAuthorship W4362567099A5028307612 @default.
- W4362567099 hasAuthorship W4362567099A5042532963 @default.
- W4362567099 hasAuthorship W4362567099A5044034428 @default.
- W4362567099 hasAuthorship W4362567099A5045377550 @default.
- W4362567099 hasAuthorship W4362567099A5047287901 @default.
- W4362567099 hasAuthorship W4362567099A5051401435 @default.
- W4362567099 hasAuthorship W4362567099A5055755196 @default.
- W4362567099 hasAuthorship W4362567099A5081887769 @default.
- W4362567099 hasAuthorship W4362567099A5085343869 @default.
- W4362567099 hasBestOaLocation W43625670992 @default.
- W4362567099 hasConcept C104317684 @default.
- W4362567099 hasConcept C126322002 @default.
- W4362567099 hasConcept C134018914 @default.
- W4362567099 hasConcept C185592680 @default.
- W4362567099 hasConcept C19038510 @default.
- W4362567099 hasConcept C2776834966 @default.
- W4362567099 hasConcept C2778772119 @default.
- W4362567099 hasConcept C2779134260 @default.
- W4362567099 hasConcept C543025807 @default.
- W4362567099 hasConcept C55493867 @default.
- W4362567099 hasConcept C62231903 @default.
- W4362567099 hasConcept C71924100 @default.
- W4362567099 hasConcept C86803240 @default.
- W4362567099 hasConceptScore W4362567099C104317684 @default.
- W4362567099 hasConceptScore W4362567099C126322002 @default.
- W4362567099 hasConceptScore W4362567099C134018914 @default.
- W4362567099 hasConceptScore W4362567099C185592680 @default.
- W4362567099 hasConceptScore W4362567099C19038510 @default.
- W4362567099 hasConceptScore W4362567099C2776834966 @default.
- W4362567099 hasConceptScore W4362567099C2778772119 @default.
- W4362567099 hasConceptScore W4362567099C2779134260 @default.
- W4362567099 hasConceptScore W4362567099C543025807 @default.
- W4362567099 hasConceptScore W4362567099C55493867 @default.
- W4362567099 hasConceptScore W4362567099C62231903 @default.
- W4362567099 hasConceptScore W4362567099C71924100 @default.
- W4362567099 hasConceptScore W4362567099C86803240 @default.
- W4362567099 hasLocation W43625670991 @default.
- W4362567099 hasLocation W43625670992 @default.
- W4362567099 hasOpenAccess W4362567099 @default.
- W4362567099 hasPrimaryLocation W43625670991 @default.
- W4362567099 hasRelatedWork W2011248462 @default.
- W4362567099 hasRelatedWork W2019374231 @default.
- W4362567099 hasRelatedWork W2035654041 @default.
- W4362567099 hasRelatedWork W2041949500 @default.
- W4362567099 hasRelatedWork W2060643724 @default.
- W4362567099 hasRelatedWork W2102326852 @default.
- W4362567099 hasRelatedWork W2135107000 @default.
- W4362567099 hasRelatedWork W2154264779 @default.
- W4362567099 hasRelatedWork W4283812354 @default.
- W4362567099 hasRelatedWork W2189310716 @default.
- W4362567099 isParatext "false" @default.
- W4362567099 isRetracted "false" @default.
- W4362567099 workType "article" @default.