FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362567741> ?p ?o ?g. }

• W4362567741 abstract "<div>Abstract<p>p53 is one of the most important tumor suppressor genes, and it is frequently inactivated in various cancers. p53 modulates various cellular functions, such as apoptosis and cell-cycle arrest via transcriptional regulation. Recently, p53 has been reported to be involved in a wide range of cellular metabolic pathways, including glycolysis, oxidative phosphorylation, glutaminolysis, and the antioxidant response. To understand the functional mechanism of p53, it is important to find out the direct transcriptional targets of p53. In this study, aldo-keto reductase family 1, member B10 (AKR1B10) was identified as a direct target of the p53 family by cDNA microarray analysis after comparing the mRNA expression of control and H1299 cells that overexpressed with p53 family members. In addition, we found that the expression of AKR1B10 was significantly decreased in colorectal cancers and adenomas as compared with normal colon tissues. Knockdown of AKR1B10 significantly inhibited p53-induced apoptosis in colorectal cancer cells, whereas the overexpression of AKR1B10 enhanced p53-induced apoptosis and inhibited tumor proliferation <i>in vivo</i>. Furthermore, low expression of AKR1B10 in colon cancer patients was correlated with decreased survival and poor prognosis. These results suggest that decreased expression of AKR1B10 could disrupt the tumor suppressive function of p53, which result in decreased survival in colorectal cancer patients. In summary, AKR1B10 may be a novel prognostic predictor and a novel therapeutic target for colorectal cancer.</p><p><b>Implications:</b> AKR1B10, a transcriptional target of p53, is also a novel prognostic and therapeutic molecule in colorectal cancer. <i>Mol Cancer Res; 11(12); 1554–63. ©2013 AACR</i>.</p></div>" @default.
• W4362567741 created "2023-04-06" @default.
• W4362567741 creator A5005311940 @default.
• W4362567741 creator A5007443182 @default.
• W4362567741 creator A5017509287 @default.
• W4362567741 creator A5054318471 @default.
• W4362567741 creator A5064856279 @default.
• W4362567741 date "2023-04-03" @default.
• W4362567741 modified "2023-09-30" @default.
• W4362567741 title "Data from AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis" @default.
• W4362567741 doi "https://doi.org/10.1158/1541-7786.c.6539292.v1" @default.
• W4362567741 hasPublicationYear "2023" @default.
• W4362567741 type Work @default.
• W4362567741 citedByCount "0" @default.
• W4362567741 crossrefType "posted-content" @default.
• W4362567741 hasAuthorship W4362567741A5005311940 @default.
• W4362567741 hasAuthorship W4362567741A5007443182 @default.
• W4362567741 hasAuthorship W4362567741A5017509287 @default.
• W4362567741 hasAuthorship W4362567741A5054318471 @default.
• W4362567741 hasAuthorship W4362567741A5064856279 @default.
• W4362567741 hasConcept C111669997 @default.
• W4362567741 hasConcept C121608353 @default.
• W4362567741 hasConcept C126322002 @default.
• W4362567741 hasConcept C173396325 @default.
• W4362567741 hasConcept C190283241 @default.
• W4362567741 hasConcept C502942594 @default.
• W4362567741 hasConcept C526805850 @default.
• W4362567741 hasConcept C54355233 @default.
• W4362567741 hasConcept C71924100 @default.
• W4362567741 hasConcept C86803240 @default.
• W4362567741 hasConceptScore W4362567741C111669997 @default.
• W4362567741 hasConceptScore W4362567741C121608353 @default.
• W4362567741 hasConceptScore W4362567741C126322002 @default.
• W4362567741 hasConceptScore W4362567741C173396325 @default.
• W4362567741 hasConceptScore W4362567741C190283241 @default.
• W4362567741 hasConceptScore W4362567741C502942594 @default.
• W4362567741 hasConceptScore W4362567741C526805850 @default.
• W4362567741 hasConceptScore W4362567741C54355233 @default.
• W4362567741 hasConceptScore W4362567741C71924100 @default.
• W4362567741 hasConceptScore W4362567741C86803240 @default.
• W4362567741 hasLocation W43625677411 @default.
• W4362567741 hasOpenAccess W4362567741 @default.
• W4362567741 hasPrimaryLocation W43625677411 @default.
• W4362567741 hasRelatedWork W2333741020 @default.
• W4362567741 hasRelatedWork W2725297161 @default.
• W4362567741 hasRelatedWork W2910817051 @default.
• W4362567741 hasRelatedWork W2914735386 @default.
• W4362567741 hasRelatedWork W2962756305 @default.
• W4362567741 hasRelatedWork W3045584038 @default.
• W4362567741 hasRelatedWork W3113198240 @default.
• W4362567741 hasRelatedWork W3171475473 @default.
• W4362567741 hasRelatedWork W4309211534 @default.
• W4362567741 hasRelatedWork W4311343083 @default.
• W4362567741 isParatext "false" @default.
• W4362567741 isRetracted "false" @default.
• W4362567741 workType "article" @default.