FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362574927> ?p ?o ?g. }

• W4362574927 endingPage "1181" @default.
• W4362574927 startingPage "1171" @default.
• W4362574927 abstract "The blockade of the CD154-CD40 pathway with anti-CD154 monoclonal antibody has been a promising immunomodulatory approach to prevent allograft rejection. However, clinical trials of immunoglobulin G1 antibodies targeting this pathway revealed thrombogenic properties, which were subsequently shown to be mediated by crystallizable fragment (Fc)-gamma receptor IIa-dependent platelet activation. To prevent thromboembolic complications, an immunoglobulin G4 anti-CD154 monoclonal antibody, TNX-1500, which retains the fragment antigen binding region of ruplizumab (humanized 5c8, BG9588), was modified by protein engineering to decrease Fc binding to Fc-gamma receptor IIa while retaining certain other effector functions and pharmacokinetics comparable with natural antibodies. Here, we report that TNX-1500 treatment is not associated with platelet activation in vitro and consistently inhibits kidney allograft rejection in vivo without clinical or histologic evidence of prothrombotic phenomena. We conclude that TNX-1500 retains efficacy similar to that of 5c8 to prevent kidney allograft rejection while avoiding previously identified pathway-associated thromboembolic complications." @default.
• W4362574927 created "2023-04-06" @default.
• W4362574927 creator A5003663239 @default.
• W4362574927 creator A5004055641 @default.
• W4362574927 creator A5009014767 @default.
• W4362574927 creator A5011634251 @default.
• W4362574927 creator A5018331943 @default.
• W4362574927 creator A5019248592 @default.
• W4362574927 creator A5019361113 @default.
• W4362574927 creator A5021948958 @default.
• W4362574927 creator A5023332183 @default.
• W4362574927 creator A5029110906 @default.
• W4362574927 creator A5031922069 @default.
• W4362574927 creator A5033240623 @default.
• W4362574927 creator A5034097416 @default.
• W4362574927 creator A5049287173 @default.
• W4362574927 creator A5051447758 @default.
• W4362574927 creator A5065845374 @default.
• W4362574927 creator A5066935883 @default.
• W4362574927 creator A5074596928 @default.
• W4362574927 creator A5075258210 @default.
• W4362574927 creator A5077948963 @default.
• W4362574927 creator A5089794335 @default.
• W4362574927 date "2023-08-01" @default.
• W4362574927 modified "2023-10-17" @default.
• W4362574927 title "TNX-1500, a crystallizable fragment–modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival" @default.
• W4362574927 cites W1485526722 @default.
• W4362574927 cites W1581554632 @default.
• W4362574927 cites W1857341452 @default.
• W4362574927 cites W1914573154 @default.
• W4362574927 cites W2029957805 @default.
• W4362574927 cites W2038981426 @default.
• W4362574927 cites W2059854760 @default.
• W4362574927 cites W2066054693 @default.
• W4362574927 cites W2068128688 @default.
• W4362574927 cites W2083063864 @default.
• W4362574927 cites W2084426169 @default.
• W4362574927 cites W2103867640 @default.
• W4362574927 cites W2130168880 @default.
• W4362574927 cites W2148044324 @default.
• W4362574927 cites W2148838644 @default.
• W4362574927 cites W2165467521 @default.
• W4362574927 cites W2198491966 @default.
• W4362574927 cites W2317185835 @default.
• W4362574927 cites W2345347546 @default.
• W4362574927 cites W2576472127 @default.
• W4362574927 cites W2615149321 @default.
• W4362574927 cites W2782216943 @default.
• W4362574927 cites W3010377113 @default.
• W4362574927 cites W3168551559 @default.
• W4362574927 cites W3185973121 @default.
• W4362574927 doi "https://doi.org/10.1016/j.ajt.2023.03.022" @default.
• W4362574927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37019335" @default.
• W4362574927 hasPublicationYear "2023" @default.
• W4362574927 type Work @default.
• W4362574927 citedByCount "4" @default.
• W4362574927 countsByYear W43625749272023 @default.
• W4362574927 crossrefType "journal-article" @default.
• W4362574927 hasAuthorship W4362574927A5003663239 @default.
• W4362574927 hasAuthorship W4362574927A5004055641 @default.
• W4362574927 hasAuthorship W4362574927A5009014767 @default.
• W4362574927 hasAuthorship W4362574927A5011634251 @default.
• W4362574927 hasAuthorship W4362574927A5018331943 @default.
• W4362574927 hasAuthorship W4362574927A5019248592 @default.
• W4362574927 hasAuthorship W4362574927A5019361113 @default.
• W4362574927 hasAuthorship W4362574927A5021948958 @default.
• W4362574927 hasAuthorship W4362574927A5023332183 @default.
• W4362574927 hasAuthorship W4362574927A5029110906 @default.
• W4362574927 hasAuthorship W4362574927A5031922069 @default.
• W4362574927 hasAuthorship W4362574927A5033240623 @default.
• W4362574927 hasAuthorship W4362574927A5034097416 @default.
• W4362574927 hasAuthorship W4362574927A5049287173 @default.
• W4362574927 hasAuthorship W4362574927A5051447758 @default.
• W4362574927 hasAuthorship W4362574927A5065845374 @default.
• W4362574927 hasAuthorship W4362574927A5066935883 @default.
• W4362574927 hasAuthorship W4362574927A5074596928 @default.
• W4362574927 hasAuthorship W4362574927A5075258210 @default.
• W4362574927 hasAuthorship W4362574927A5077948963 @default.
• W4362574927 hasAuthorship W4362574927A5089794335 @default.
• W4362574927 hasBestOaLocation W43625749271 @default.
• W4362574927 hasConcept C126322002 @default.
• W4362574927 hasConcept C150903083 @default.
• W4362574927 hasConcept C154317977 @default.
• W4362574927 hasConcept C159654299 @default.
• W4362574927 hasConcept C170493617 @default.
• W4362574927 hasConcept C202751555 @default.
• W4362574927 hasConcept C203014093 @default.
• W4362574927 hasConcept C207001950 @default.
• W4362574927 hasConcept C2778468042 @default.
• W4362574927 hasConcept C2779234475 @default.
• W4362574927 hasConcept C2780091579 @default.
• W4362574927 hasConcept C2780303639 @default.
• W4362574927 hasConcept C2911091166 @default.
• W4362574927 hasConcept C39347974 @default.
• W4362574927 hasConcept C542903549 @default.
• W4362574927 hasConcept C55493867 @default.
• W4362574927 hasConcept C71924100 @default.
• W4362574927 hasConcept C86803240 @default.

• next