FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362574989> ?p ?o ?g. }

• W4362574989 endingPage "106872" @default.
• W4362574989 startingPage "106872" @default.
• W4362574989 abstract "Belonging to type 1 innate lymphoid cells (ILC1), natural killer (NK) cells play an important role not only in fighting microbial infections but also in anti-tumor response. Hepatocellular carcinoma (HCC) represents an inflammation-related malignancy and NK cells are enriched in the liver, making them an essential component of the HCC immune microenvironment. In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis to identify the NK cell marker genes (NKGs) and uncovered 80 prognosis-related ones by the TCGA-LIHC dataset. Based on prognostic NKGs, HCC patients were categorized into two subtypes with distinct clinical outcomes. Subsequently, we conducted LASSO-COX and stepwise regression analysis on prognostic NKGs to establish a five-gene (UBB, CIRBP, GZMH, NUDC, and NCL) prognostic signature-NKscore. Different mutation statuses of the two risk groups stratified by NKscore were comprehensively characterized. Besides, the established NKscore-integrated nomogram presented enhanced predictive performance. Single sample gene set enrichment analysis (ssGSEA) analysis was used to uncover the landscape of the tumor immune microenvironment (TIME) and the high-NKscore risk group was characterized with an immune-exhausted phenotype while the low-NKscore risk group held relatively strong anti-cancer immunity. T cell receptor (TCR) repertoire, tumor inflammation signature (TIS), and Immunophenoscore (IPS) analyses revealed differences in immunotherapy sensitivity between the two NKscore risk groups. Taken together, we developed a novel NK cell-related signature to predict the prognosis and immunotherapy efficacy for HCC patients." @default.
• W4362574989 created "2023-04-06" @default.
• W4362574989 creator A5002670108 @default.
• W4362574989 creator A5005243450 @default.
• W4362574989 creator A5025924166 @default.
• W4362574989 creator A5050319863 @default.
• W4362574989 creator A5052206633 @default.
• W4362574989 creator A5052485047 @default.
• W4362574989 creator A5082224007 @default.
• W4362574989 date "2023-05-01" @default.
• W4362574989 modified "2023-09-29" @default.
• W4362574989 title "Deciphering the immune heterogeneity dominated by natural killer cells with prognostic and therapeutic implications in hepatocellular carcinoma" @default.
• W4362574989 cites W1491394604 @default.
• W4362574989 cites W1835730169 @default.
• W4362574989 cites W1877911682 @default.
• W4362574989 cites W1904885158 @default.
• W4362574989 cites W1966107523 @default.
• W4362574989 cites W1966542058 @default.
• W4362574989 cites W1994993231 @default.
• W4362574989 cites W2028433016 @default.
• W4362574989 cites W2033107431 @default.
• W4362574989 cites W2035618305 @default.
• W4362574989 cites W2052730188 @default.
• W4362574989 cites W2086818383 @default.
• W4362574989 cites W2091148267 @default.
• W4362574989 cites W2094652659 @default.
• W4362574989 cites W2102862705 @default.
• W4362574989 cites W2115462905 @default.
• W4362574989 cites W2128804867 @default.
• W4362574989 cites W2130430382 @default.
• W4362574989 cites W2146512944 @default.
• W4362574989 cites W2159707944 @default.
• W4362574989 cites W2167550136 @default.
• W4362574989 cites W2170547473 @default.
• W4362574989 cites W2171709048 @default.
• W4362574989 cites W2214074259 @default.
• W4362574989 cites W2230320310 @default.
• W4362574989 cites W2533508881 @default.
• W4362574989 cites W2564351475 @default.
• W4362574989 cites W2593030814 @default.
• W4362574989 cites W2606495925 @default.
• W4362574989 cites W2624831627 @default.
• W4362574989 cites W2751640563 @default.
• W4362574989 cites W2754790404 @default.
• W4362574989 cites W2761575992 @default.
• W4362574989 cites W2774983464 @default.
• W4362574989 cites W2785803176 @default.
• W4362574989 cites W2788548733 @default.
• W4362574989 cites W2792376809 @default.
• W4362574989 cites W2794480084 @default.
• W4362574989 cites W2795867722 @default.
• W4362574989 cites W2796207838 @default.
• W4362574989 cites W2808909747 @default.
• W4362574989 cites W2809092757 @default.
• W4362574989 cites W2865352686 @default.
• W4362574989 cites W2867818201 @default.
• W4362574989 cites W2889052854 @default.
• W4362574989 cites W2896872272 @default.
• W4362574989 cites W2899141307 @default.
• W4362574989 cites W2901262057 @default.
• W4362574989 cites W2904803926 @default.
• W4362574989 cites W2909679049 @default.
• W4362574989 cites W2922356294 @default.
• W4362574989 cites W2937441321 @default.
• W4362574989 cites W2941731087 @default.
• W4362574989 cites W2949273159 @default.
• W4362574989 cites W2949746977 @default.
• W4362574989 cites W2952311394 @default.
• W4362574989 cites W2969802526 @default.
• W4362574989 cites W2972917142 @default.
• W4362574989 cites W2982638381 @default.
• W4362574989 cites W2990323558 @default.
• W4362574989 cites W2992088875 @default.
• W4362574989 cites W3010504173 @default.
• W4362574989 cites W3012211502 @default.
• W4362574989 cites W3012837954 @default.
• W4362574989 cites W3013784125 @default.
• W4362574989 cites W3015646919 @default.
• W4362574989 cites W3016811071 @default.
• W4362574989 cites W3025022288 @default.
• W4362574989 cites W3037237663 @default.
• W4362574989 cites W3039445960 @default.
• W4362574989 cites W3044424538 @default.
• W4362574989 cites W3044821911 @default.
• W4362574989 cites W3045029533 @default.
• W4362574989 cites W3045852659 @default.
• W4362574989 cites W3082682051 @default.
• W4362574989 cites W3083391098 @default.
• W4362574989 cites W3087952073 @default.
• W4362574989 cites W3094862578 @default.
• W4362574989 cites W3110372791 @default.
• W4362574989 cites W3111605591 @default.
• W4362574989 cites W3118017075 @default.
• W4362574989 cites W3119281926 @default.
• W4362574989 cites W3122102409 @default.
• W4362574989 cites W3123469366 @default.
• W4362574989 cites W3127402714 @default.
• W4362574989 cites W3127961017 @default.

• next