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• W4362576741 endingPage "138570" @default.
• W4362576741 startingPage "138570" @default.
• W4362576741 abstract "Parabens are widely used as antimicrobial preservatives in personal care products. Studies investigating obesogenic or cardiovascular effects of parabens show discordant results, while data on preschool children are lacking. Paraben exposure during early childhood could have profound cardiometabolic effects later in life. In this cross-sectional study paraben concentrations [methyl (MeP), ethyl (EtP), propyl (PrP), butyl (BuP)] were measured by ultra-performance liquid chromatography/tandem mass spectrometry in 300 urinary samples of 4-6-year-old children of the ENVIRONAGE birth cohort. Paraben values below the limit of quantitation (LOQ) were imputed by censored likelihood multiple imputation. The associations between log-transformed paraben values and cardiometabolic measurements (BMI z-scores, waist circumference, blood pressure and retinal microvasculature) were analyzed in multiple linear regression models with a priori selected covariates. Effect modification by sex was investigated by including interaction terms. Geometric means (geometric SD) of urinary MeP, EtP, and PrP levels above the LOQ were 32.60 (6.64), 1.26 (3.45), and 4.82 (4.11) μg/L, respectively. For BuP more than 96% of all measurements were below the LOQ. Regarding the microvasculature, we found direct associations between MeP and central retinal venular equivalent (β = 1.23, p = 0.039) and PrP with the retinal tortuosity index (x103)(β = 1.75, p = 0.0044). Furthermore, we identified inverse associations between MeP and ∑parabens with BMI z-scores (β = −0.067, p = 0.015 and β = −0.070, p = 0.014 respectively), and EtP with mean arterial pressure (β = −0.69, p = 0.048). The direction of association between EtP and BMI z-scores showed evidence for sex-specific differences with a direct trend in boys (β = 0.10, p = 0.060). Already at young age paraben exposure is associated with potentially adverse changes in the retinal microvasculature." @default.
• W4362576741 created "2023-04-06" @default.
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• W4362576741 date "2023-07-01" @default.
• W4362576741 modified "2023-10-14" @default.
• W4362576741 title "Exposure to endocrine disrupters and cardiometabolic health effects in preschool children: Urinary parabens are associated with wider retinal venular vessels" @default.
• W4362576741 cites W1966114904 @default.
• W4362576741 cites W1971194701 @default.
• W4362576741 cites W1977604459 @default.
• W4362576741 cites W1981921464 @default.
• W4362576741 cites W1984385866 @default.
• W4362576741 cites W1986933738 @default.
• W4362576741 cites W1988943742 @default.
• W4362576741 cites W1991694614 @default.
• W4362576741 cites W1993427098 @default.
• W4362576741 cites W2002867647 @default.
• W4362576741 cites W2010495535 @default.
• W4362576741 cites W2013865699 @default.
• W4362576741 cites W2017930290 @default.
• W4362576741 cites W2028971810 @default.
• W4362576741 cites W2036270427 @default.
• W4362576741 cites W2037645904 @default.
• W4362576741 cites W2039177968 @default.
• W4362576741 cites W2042872420 @default.
• W4362576741 cites W2049287094 @default.
• W4362576741 cites W2054141773 @default.
• W4362576741 cites W2059571803 @default.
• W4362576741 cites W2062049572 @default.
• W4362576741 cites W2069115606 @default.
• W4362576741 cites W2073874214 @default.
• W4362576741 cites W2079531538 @default.
• W4362576741 cites W2092685208 @default.
• W4362576741 cites W2097260668 @default.
• W4362576741 cites W2102433335 @default.
• W4362576741 cites W2106079471 @default.
• W4362576741 cites W2114444511 @default.
• W4362576741 cites W2121913681 @default.
• W4362576741 cites W2123498365 @default.
• W4362576741 cites W2124821727 @default.
• W4362576741 cites W2141460031 @default.
• W4362576741 cites W2151672477 @default.
• W4362576741 cites W2151913401 @default.
• W4362576741 cites W2161461075 @default.
• W4362576741 cites W2166364317 @default.
• W4362576741 cites W2167543749 @default.
• W4362576741 cites W2170036922 @default.
• W4362576741 cites W2205803035 @default.
• W4362576741 cites W2214691690 @default.
• W4362576741 cites W2346394679 @default.
• W4362576741 cites W2508617386 @default.
• W4362576741 cites W2564350820 @default.
• W4362576741 cites W2747721206 @default.
• W4362576741 cites W2762153312 @default.
• W4362576741 cites W2790174619 @default.
• W4362576741 cites W2800321587 @default.
• W4362576741 cites W2810582386 @default.
• W4362576741 cites W2884057346 @default.
• W4362576741 cites W2885490402 @default.
• W4362576741 cites W2894686785 @default.
• W4362576741 cites W2900875420 @default.
• W4362576741 cites W2903484614 @default.
• W4362576741 cites W2906699453 @default.
• W4362576741 cites W2918173153 @default.
• W4362576741 cites W2922291146 @default.
• W4362576741 cites W2951345394 @default.
• W4362576741 cites W2951432696 @default.
• W4362576741 cites W2957811995 @default.
• W4362576741 cites W2968787706 @default.
• W4362576741 cites W2971737841 @default.
• W4362576741 cites W2983800014 @default.
• W4362576741 cites W2985510552 @default.
• W4362576741 cites W2991526710 @default.
• W4362576741 cites W2998236074 @default.
• W4362576741 cites W3025168536 @default.
• W4362576741 cites W3044144735 @default.
• W4362576741 cites W3080435270 @default.
• W4362576741 cites W3093262577 @default.
• W4362576741 cites W3096557206 @default.
• W4362576741 cites W3133790816 @default.
• W4362576741 cites W3146212268 @default.
• W4362576741 cites W3176505609 @default.
• W4362576741 cites W3180282497 @default.
• W4362576741 cites W3196805611 @default.
• W4362576741 cites W4200590461 @default.
• W4362576741 cites W4211123041 @default.
• W4362576741 cites W4213137916 @default.
• W4362576741 cites W4296311586 @default.
• W4362576741 cites W3197213052 @default.
• W4362576741 doi "https://doi.org/10.1016/j.chemosphere.2023.138570" @default.
• W4362576741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37019399" @default.

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