Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362577303> ?p ?o ?g. }
- W4362577303 abstract "During the postnatal period in mammals, the heart undergoes significant remodeling in response to increased circulatory demands. In the days after birth, cardiac cells, including cardiomyocytes and fibroblasts, progressively lose embryonic characteristics concomitant with the loss of the heart's ability to regenerate. Moreover, postnatal cardiomyocytes undergo binucleation and cell cycle arrest with induction of hypertrophic growth, while cardiac fibroblasts proliferate and produce extracellular matrix (ECM) that transitions from components that support cellular maturation to production of the mature fibrous skeleton of the heart. Recent studies have implicated interactions of cardiac fibroblasts and cardiomyocytes within the maturing ECM environment to promote heart maturation in the postnatal period. Here, we review the relationships of different cardiac cell types and the ECM as the heart undergoes both structural and functional changes during development. Recent advances in the field, particularly in several recently published transcriptomic datasets, have highlighted specific signaling mechanisms that underlie cellular maturation and demonstrated the biomechanical interdependence of cardiac fibroblast and cardiomyocyte maturation. There is increasing evidence that postnatal heart development in mammals is dependent on particular ECM components and that resulting changes in biomechanics influence cell maturation. These advances, in definition of cardiac fibroblast heterogeneity and function in relation to cardiomyocyte maturation and the extracellular environment provide, support for complex cell crosstalk in the postnatal heart with implications for heart regeneration and disease mechanisms." @default.
- W4362577303 created "2023-04-06" @default.
- W4362577303 creator A5013858379 @default.
- W4362577303 creator A5030290137 @default.
- W4362577303 creator A5036524102 @default.
- W4362577303 date "2023-04-03" @default.
- W4362577303 modified "2023-10-01" @default.
- W4362577303 title "Cardiomyocyte-fibroblast crosstalk in the postnatal heart" @default.
- W4362577303 cites W10095287 @default.
- W4362577303 cites W1578501129 @default.
- W4362577303 cites W1669479280 @default.
- W4362577303 cites W1941615070 @default.
- W4362577303 cites W1964179882 @default.
- W4362577303 cites W1969038150 @default.
- W4362577303 cites W1969193847 @default.
- W4362577303 cites W1974848384 @default.
- W4362577303 cites W1978368033 @default.
- W4362577303 cites W1981083884 @default.
- W4362577303 cites W1986199873 @default.
- W4362577303 cites W1986421392 @default.
- W4362577303 cites W2003035943 @default.
- W4362577303 cites W2006743934 @default.
- W4362577303 cites W2007916618 @default.
- W4362577303 cites W2009682316 @default.
- W4362577303 cites W2013244803 @default.
- W4362577303 cites W2016864623 @default.
- W4362577303 cites W2017770112 @default.
- W4362577303 cites W2018196430 @default.
- W4362577303 cites W2019119739 @default.
- W4362577303 cites W2020087937 @default.
- W4362577303 cites W2024356705 @default.
- W4362577303 cites W2027698896 @default.
- W4362577303 cites W2034238319 @default.
- W4362577303 cites W2035847235 @default.
- W4362577303 cites W2040690361 @default.
- W4362577303 cites W2042773729 @default.
- W4362577303 cites W2049435445 @default.
- W4362577303 cites W2052583014 @default.
- W4362577303 cites W2058112316 @default.
- W4362577303 cites W2067500648 @default.
- W4362577303 cites W2069923609 @default.
- W4362577303 cites W2071765960 @default.
- W4362577303 cites W2077226203 @default.
- W4362577303 cites W2079006323 @default.
- W4362577303 cites W2079155642 @default.
- W4362577303 cites W2082714048 @default.
- W4362577303 cites W2090836361 @default.
- W4362577303 cites W2093494581 @default.
- W4362577303 cites W2102790195 @default.
- W4362577303 cites W2110275759 @default.
- W4362577303 cites W2110458816 @default.
- W4362577303 cites W2116965334 @default.
- W4362577303 cites W2117246483 @default.
- W4362577303 cites W2128606426 @default.
- W4362577303 cites W2134039588 @default.
- W4362577303 cites W2135767680 @default.
- W4362577303 cites W2144283689 @default.
- W4362577303 cites W2149542575 @default.
- W4362577303 cites W2150501736 @default.
- W4362577303 cites W2183587606 @default.
- W4362577303 cites W2191859395 @default.
- W4362577303 cites W2267961811 @default.
- W4362577303 cites W2299099463 @default.
- W4362577303 cites W2316191280 @default.
- W4362577303 cites W2482213414 @default.
- W4362577303 cites W2487675594 @default.
- W4362577303 cites W2530928249 @default.
- W4362577303 cites W2549840432 @default.
- W4362577303 cites W2608644283 @default.
- W4362577303 cites W2612184340 @default.
- W4362577303 cites W2623156160 @default.
- W4362577303 cites W2745087321 @default.
- W4362577303 cites W2747822643 @default.
- W4362577303 cites W2750808153 @default.
- W4362577303 cites W2758667350 @default.
- W4362577303 cites W2768398928 @default.
- W4362577303 cites W2789133580 @default.
- W4362577303 cites W2790649837 @default.
- W4362577303 cites W2795900237 @default.
- W4362577303 cites W2800350399 @default.
- W4362577303 cites W2802362350 @default.
- W4362577303 cites W2807862873 @default.
- W4362577303 cites W2883350147 @default.
- W4362577303 cites W2884217607 @default.
- W4362577303 cites W2886927628 @default.
- W4362577303 cites W2889074368 @default.
- W4362577303 cites W2905379256 @default.
- W4362577303 cites W2920801774 @default.
- W4362577303 cites W2951691172 @default.
- W4362577303 cites W2963493357 @default.
- W4362577303 cites W2969663966 @default.
- W4362577303 cites W2971227980 @default.
- W4362577303 cites W2980098439 @default.
- W4362577303 cites W2996171578 @default.
- W4362577303 cites W3025989739 @default.
- W4362577303 cites W3044560529 @default.
- W4362577303 cites W3073734492 @default.
- W4362577303 cites W3086145959 @default.
- W4362577303 cites W3096345853 @default.
- W4362577303 cites W3111084394 @default.