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- W4362579073 endingPage "2099" @default.
- W4362579073 startingPage "2099" @default.
- W4362579073 abstract "Leiomyosarcoma (LMS) is a rare, aggressive mesenchymal tumor with smooth muscle differentiation. LMS is one of the most common histologic subtypes of soft tissue sarcoma; it most frequently occurs in the extremities, retroperitoneum, or uterus. LMS often demonstrates aggressive tumor biology, with a higher risk of developing distant metastatic disease than most sarcoma histologic types. The prognosis is poor, particularly in patients with uterine disease, and there is a need for the development of more effective therapies. Genetically, LMS is karyotypically complex and characterized by a low tumor mutational burden, with frequent alterations in TP53, RB1, PTEN, and DNA damage response pathways that may contribute to resistance against immune-checkpoint blockade monotherapy. The LMS immune microenvironment is highly infiltrated with tumor-associated macrophages and tumor-infiltrating lymphocytes, which may represent promising biomarkers. This review provides an overview of the clinical and pathologic behavior of both soft tissue and uterine LMS and summarizes the genomic and immune characteristics of these tumors and how they may provide opportunities for the development of biomarker-based immune therapies." @default.
- W4362579073 created "2023-04-06" @default.
- W4362579073 creator A5002293304 @default.
- W4362579073 creator A5013010787 @default.
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- W4362579073 creator A5079909397 @default.
- W4362579073 creator A5084503525 @default.
- W4362579073 creator A5086634878 @default.
- W4362579073 date "2023-03-31" @default.
- W4362579073 modified "2023-09-25" @default.
- W4362579073 title "Targeting the Molecular and Immunologic Features of Leiomyosarcoma" @default.
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