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- W4362579423 endingPage "6628" @default.
- W4362579423 startingPage "6628" @default.
- W4362579423 abstract "Kidney transplantation (KT) may improve the neurological status of chronic kidney disease (CKD) patients, reflected by the altered levels of circulating BBB-specific biomarkers. This study compares the levels of neuron specific enolase (NSE), brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL), and circulating plasma extracellular vesicles (EVs) in kidney-failure patients before KT and at a two-year follow up. Using ELISA, NSE, BDNF, and NfL levels were measured in the plasma of 74 living-donor KT patients. Plasma EVs were isolated with ultracentrifugation, and characterized for concentration/size and surface protein expression using flow cytometry from a subset of 25 patients. Lower NSE levels, and higher BDNF and NfL were observed at the two-year follow-up compared to the baseline (p < 0.05). Male patients had significantly higher BDNF levels compared to those of females. BBB biomarkers correlated with the baseline lipid profile and with glucose, vitamin D, and inflammation markers after KT. BBB surrogate marker changes in the microcirculation of early vascular aging phenotype patients with calcification and/or fibrosis were observed only in NSE and BDNF. CD31+ microparticles from endothelial cells expressing inflammatory markers such as CD40 and integrins were significantly reduced after KT. KT may, thus, improve the neurological status of CKD patients, as reflected by changes in BBB-specific biomarkers." @default.
- W4362579423 created "2023-04-06" @default.
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- W4362579423 date "2023-04-01" @default.
- W4362579423 modified "2023-10-08" @default.
- W4362579423 title "Blood–Brain Barrier Biomarkers before and after Kidney Transplantation" @default.
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- W4362579423 cites W1553095121 @default.
- W4362579423 cites W1960556709 @default.
- W4362579423 cites W2004166689 @default.
- W4362579423 cites W2016946333 @default.
- W4362579423 cites W2018278847 @default.
- W4362579423 cites W2030190613 @default.
- W4362579423 cites W2044628808 @default.
- W4362579423 cites W2102549964 @default.
- W4362579423 cites W2102984113 @default.
- W4362579423 cites W2103022797 @default.
- W4362579423 cites W2109355833 @default.
- W4362579423 cites W2111497121 @default.
- W4362579423 cites W2132316186 @default.
- W4362579423 cites W2137742067 @default.
- W4362579423 cites W2140485502 @default.
- W4362579423 cites W2165733730 @default.
- W4362579423 cites W2314005513 @default.
- W4362579423 cites W2318180844 @default.
- W4362579423 cites W2340997569 @default.
- W4362579423 cites W2400263775 @default.
- W4362579423 cites W2415582602 @default.
- W4362579423 cites W2516557409 @default.
- W4362579423 cites W2546832144 @default.
- W4362579423 cites W2580949479 @default.
- W4362579423 cites W2620823801 @default.
- W4362579423 cites W2676896076 @default.
- W4362579423 cites W2729131829 @default.
- W4362579423 cites W2766270781 @default.
- W4362579423 cites W2774711458 @default.
- W4362579423 cites W2781528861 @default.
- W4362579423 cites W2782594233 @default.
- W4362579423 cites W2791910913 @default.
- W4362579423 cites W2796948173 @default.
- W4362579423 cites W2804654123 @default.
- W4362579423 cites W2870743986 @default.
- W4362579423 cites W2886250128 @default.
- W4362579423 cites W2889431295 @default.
- W4362579423 cites W2892633805 @default.
- W4362579423 cites W2900756811 @default.
- W4362579423 cites W2904276522 @default.
- W4362579423 cites W2904356389 @default.
- W4362579423 cites W2913868144 @default.
- W4362579423 cites W2918417621 @default.
- W4362579423 cites W2950937096 @default.
- W4362579423 cites W2965884716 @default.
- W4362579423 cites W2968750955 @default.
- W4362579423 cites W3004767455 @default.
- W4362579423 cites W3005957464 @default.
- W4362579423 cites W3015068556 @default.
- W4362579423 cites W3016677386 @default.
- W4362579423 cites W3016718231 @default.
- W4362579423 cites W3033949881 @default.
- W4362579423 cites W3034602289 @default.
- W4362579423 cites W3047019807 @default.
- W4362579423 cites W3083702217 @default.
- W4362579423 cites W3087201259 @default.
- W4362579423 cites W3097365520 @default.
- W4362579423 cites W3107584533 @default.
- W4362579423 cites W3109302234 @default.
- W4362579423 cites W3117257117 @default.
- W4362579423 cites W3119511530 @default.
- W4362579423 cites W3126342051 @default.
- W4362579423 cites W3132267651 @default.
- W4362579423 cites W3153948139 @default.
- W4362579423 cites W3162550064 @default.
- W4362579423 cites W3177097629 @default.
- W4362579423 cites W3181285032 @default.
- W4362579423 cites W3197141608 @default.
- W4362579423 cites W3204792708 @default.
- W4362579423 cites W3217602795 @default.
- W4362579423 cites W4200284563 @default.
- W4362579423 cites W4210721627 @default.
- W4362579423 cites W4220898697 @default.
- W4362579423 cites W4221045372 @default.
- W4362579423 cites W4229031593 @default.
- W4362579423 cites W4280512011 @default.
- W4362579423 cites W4283164570 @default.
- W4362579423 cites W4285719527 @default.
- W4362579423 cites W4303614255 @default.
- W4362579423 doi "https://doi.org/10.3390/ijms24076628" @default.
- W4362579423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37047601" @default.
- W4362579423 hasPublicationYear "2023" @default.