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- W4362580108 endingPage "3160" @default.
- W4362580108 startingPage "3160" @default.
- W4362580108 abstract "Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced hepatitis, cirrhosis, and liver cancer are the primary causes of liver-related morbidity and mortality. A hallmark of DILI is ERS and changes in mitochondrial morphology and function, which increase the production of reactive oxygen species (ROS) in a vicious cycle of mutually reinforcing stress responses. Several pathways are maladapted to maintain homeostasis during DILI. Here, we discuss the processes of liver injury caused by several types of drugs that induce hepatocyte stress, focusing primarily on DILI by ERS and mitochondrial stress. Importantly, both ERS and mitochondrial stress are mediated by the overproduction of ROS, destruction of Ca2+ homeostasis, and unfolded protein response (UPR). Additionally, we review new pathways and potential pharmacological targets for DILI to highlight new possibilities for DILI treatment and mitigation." @default.
- W4362580108 created "2023-04-06" @default.
- W4362580108 creator A5000508402 @default.
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- W4362580108 creator A5036726873 @default.
- W4362580108 creator A5046634483 @default.
- W4362580108 creator A5090111661 @default.
- W4362580108 date "2023-04-02" @default.
- W4362580108 modified "2023-10-12" @default.
- W4362580108 title "Endoplasmic Reticulum Stress and Mitochondrial Stress in Drug-Induced Liver Injury" @default.
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