FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362583017> ?p ?o ?g. }

• W4362583017 endingPage "S289" @default.
• W4362583017 startingPage "S289" @default.
• W4362583017 abstract "PurposeThe advent of direct-acting antivirals has helped to increase the safe utilization of organs from hepatitis C virus (HCV) positive donors (C-Pos). However, the outcomes of heart transplantation (HT) using a C-Pos are uncertain, especially in recipients with underlying liver disease. We analyzed the outcomes of HT when utilizing C-Pos in recipients with an elevated model for end-stage liver disease excluding INR (MELD-XI), which is a marker of liver cirrhosis.MethodsThe UNOS database was queried from Jan 2016 to Dec 2021. Post-transplant outcomes stratified by MELD-XI score (low<10.37, medium 10.38-13.39, and high>13.4) was compared between recipients with HT from C-Pos (N=792) and HCV negative donors (C-Neg) (N=15,266).ResultsIn C-Pos group, recipients were older (58 vs. 57 years, P=0.001) and more male (77% vs. 73%, P=0.008). The rate of intra-aortic balloon pump and left ventricular assist device were similar. The median MELD-XI score was 11.8 in C-Neg and 12.1 (9.6, 14.7) in C-Pos group (P=0.37). In C-Pos group, donors were older (33 vs. 31 years, P<0.001) and more male (74% vs. 71%, P=0.014). Donor ischemic time was longer (3.48 vs. 3.28 hours) in C-pos group, as was the travel distance (250 vs. 157 miles, P<0.001). In Kaplan Meier analysis (follow up, median: 750 days), three-year survival was similar between groups in each MELD-XI subgroup (Low: C-Neg, 87.9% vs. C-Pos, 88.7%, P=0.83, Medium: C-Neg, 85.4% vs C-Pos, 88.1%, P=0.68, and High: C-Neg, 80.6% vs. C-Pos, 81.5%, P=0.75). In multivariate Cox hazard models, HCV donor was not associated with mortality in each MELD-XI subgroup (Low: HR, 1.02, P=0.94; Medium: 0.95, P=0.81; and High: 0.93, P=0.68).ConclusionUtilization of H-Pos heart was not associated with an increased risk of mortality in recipients with underlying liver disease as represented by an elevated MELD-XI score. Further study is warranted to better understand the impact of extended criteria donors on outcomes of HT recipients with underlying hepatic dysfunction. The advent of direct-acting antivirals has helped to increase the safe utilization of organs from hepatitis C virus (HCV) positive donors (C-Pos). However, the outcomes of heart transplantation (HT) using a C-Pos are uncertain, especially in recipients with underlying liver disease. We analyzed the outcomes of HT when utilizing C-Pos in recipients with an elevated model for end-stage liver disease excluding INR (MELD-XI), which is a marker of liver cirrhosis. The UNOS database was queried from Jan 2016 to Dec 2021. Post-transplant outcomes stratified by MELD-XI score (low<10.37, medium 10.38-13.39, and high>13.4) was compared between recipients with HT from C-Pos (N=792) and HCV negative donors (C-Neg) (N=15,266). In C-Pos group, recipients were older (58 vs. 57 years, P=0.001) and more male (77% vs. 73%, P=0.008). The rate of intra-aortic balloon pump and left ventricular assist device were similar. The median MELD-XI score was 11.8 in C-Neg and 12.1 (9.6, 14.7) in C-Pos group (P=0.37). In C-Pos group, donors were older (33 vs. 31 years, P<0.001) and more male (74% vs. 71%, P=0.014). Donor ischemic time was longer (3.48 vs. 3.28 hours) in C-pos group, as was the travel distance (250 vs. 157 miles, P<0.001). In Kaplan Meier analysis (follow up, median: 750 days), three-year survival was similar between groups in each MELD-XI subgroup (Low: C-Neg, 87.9% vs. C-Pos, 88.7%, P=0.83, Medium: C-Neg, 85.4% vs C-Pos, 88.1%, P=0.68, and High: C-Neg, 80.6% vs. C-Pos, 81.5%, P=0.75). In multivariate Cox hazard models, HCV donor was not associated with mortality in each MELD-XI subgroup (Low: HR, 1.02, P=0.94; Medium: 0.95, P=0.81; and High: 0.93, P=0.68). Utilization of H-Pos heart was not associated with an increased risk of mortality in recipients with underlying liver disease as represented by an elevated MELD-XI score. Further study is warranted to better understand the impact of extended criteria donors on outcomes of HT recipients with underlying hepatic dysfunction." @default.
• W4362583017 created "2023-04-06" @default.
• W4362583017 creator A5004732865 @default.
• W4362583017 creator A5006924907 @default.
• W4362583017 creator A5017612375 @default.
• W4362583017 creator A5017740742 @default.
• W4362583017 creator A5021190032 @default.
• W4362583017 creator A5024152052 @default.
• W4362583017 creator A5042527601 @default.
• W4362583017 creator A5049185765 @default.
• W4362583017 creator A5053034483 @default.
• W4362583017 creator A5056654500 @default.
• W4362583017 creator A5087002416 @default.
• W4362583017 date "2023-04-01" @default.
• W4362583017 modified "2023-09-25" @default.
• W4362583017 title "(647) Utilization of Hepatitis C Virus Infected Donor in Heart Transplant Recipients with Elevated Meld-Xi Score" @default.
• W4362583017 doi "https://doi.org/10.1016/j.healun.2023.02.661" @default.
• W4362583017 hasPublicationYear "2023" @default.
• W4362583017 type Work @default.
• W4362583017 citedByCount "0" @default.
• W4362583017 crossrefType "journal-article" @default.
• W4362583017 hasAuthorship W4362583017A5004732865 @default.
• W4362583017 hasAuthorship W4362583017A5006924907 @default.
• W4362583017 hasAuthorship W4362583017A5017612375 @default.
• W4362583017 hasAuthorship W4362583017A5017740742 @default.
• W4362583017 hasAuthorship W4362583017A5021190032 @default.
• W4362583017 hasAuthorship W4362583017A5024152052 @default.
• W4362583017 hasAuthorship W4362583017A5042527601 @default.
• W4362583017 hasAuthorship W4362583017A5049185765 @default.
• W4362583017 hasAuthorship W4362583017A5053034483 @default.
• W4362583017 hasAuthorship W4362583017A5056654500 @default.
• W4362583017 hasAuthorship W4362583017A5087002416 @default.
• W4362583017 hasBestOaLocation W43625830171 @default.
• W4362583017 hasConcept C126322002 @default.
• W4362583017 hasConcept C141071460 @default.
• W4362583017 hasConcept C203014093 @default.
• W4362583017 hasConcept C2522874641 @default.
• W4362583017 hasConcept C2776408679 @default.
• W4362583017 hasConcept C2776455275 @default.
• W4362583017 hasConcept C2777075537 @default.
• W4362583017 hasConcept C2777214474 @default.
• W4362583017 hasConcept C2778849806 @default.
• W4362583017 hasConcept C2779250428 @default.
• W4362583017 hasConcept C2779609443 @default.
• W4362583017 hasConcept C2911091166 @default.
• W4362583017 hasConcept C71924100 @default.
• W4362583017 hasConcept C90924648 @default.
• W4362583017 hasConceptScore W4362583017C126322002 @default.
• W4362583017 hasConceptScore W4362583017C141071460 @default.
• W4362583017 hasConceptScore W4362583017C203014093 @default.
• W4362583017 hasConceptScore W4362583017C2522874641 @default.
• W4362583017 hasConceptScore W4362583017C2776408679 @default.
• W4362583017 hasConceptScore W4362583017C2776455275 @default.
• W4362583017 hasConceptScore W4362583017C2777075537 @default.
• W4362583017 hasConceptScore W4362583017C2777214474 @default.
• W4362583017 hasConceptScore W4362583017C2778849806 @default.
• W4362583017 hasConceptScore W4362583017C2779250428 @default.
• W4362583017 hasConceptScore W4362583017C2779609443 @default.
• W4362583017 hasConceptScore W4362583017C2911091166 @default.
• W4362583017 hasConceptScore W4362583017C71924100 @default.
• W4362583017 hasConceptScore W4362583017C90924648 @default.
• W4362583017 hasIssue "4" @default.
• W4362583017 hasLocation W43625830171 @default.
• W4362583017 hasOpenAccess W4362583017 @default.
• W4362583017 hasPrimaryLocation W43625830171 @default.
• W4362583017 hasRelatedWork W1878829922 @default.
• W4362583017 hasRelatedWork W1984970689 @default.
• W4362583017 hasRelatedWork W1985834931 @default.
• W4362583017 hasRelatedWork W2009016048 @default.
• W4362583017 hasRelatedWork W2041820052 @default.
• W4362583017 hasRelatedWork W2077962329 @default.
• W4362583017 hasRelatedWork W2166316093 @default.
• W4362583017 hasRelatedWork W2972731930 @default.
• W4362583017 hasRelatedWork W3030351087 @default.
• W4362583017 hasRelatedWork W3031065119 @default.
• W4362583017 hasVolume "42" @default.
• W4362583017 isParatext "false" @default.
• W4362583017 isRetracted "false" @default.
• W4362583017 workType "article" @default.