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- W4362583886 abstract "Abstract Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment where they reside; as a consequence, their molecular and functional profiles differ among tissues and pathologies. In tumors, the features acquired by Tregs remains poorly characterized. Here, we observed that human tumor-infiltrating Tregs selectively overexpress CD74, the MHC class II invariant chain. CD74 has been previously described as a regulator of antigen-presenting cell biology, however its function in Tregs remains unknown. CD74 genetic deletion in human primary Tregs revealed that CD74KO Tregs exhibit major defects in the organization of their actin cytoskeleton and intracellular organelles. Additionally, intra-tumoral CD74KO Tregs show a decreased activation, a drop in Foxp3 expression, a low accumulation in the tumor, and consistently, they accelerate the tumor rejection. These observations are unique to tumor conditions as, at steady state, CD74KO-Treg phenotype, survival, and suppressive capacity are unaffected in vitro and in vivo. CD74 therefore emerges as a specific regulator of tumor-infiltrating Tregs and as a novel target to interfere with Treg anti-tumor activity." @default.
- W4362583886 created "2023-04-06" @default.
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- W4362583886 date "2023-04-03" @default.
- W4362583886 modified "2023-10-14" @default.
- W4362583886 title "CD74 supports Treg accumulation and function in tumors" @default.
- W4362583886 doi "https://doi.org/10.21203/rs.3.rs-2747594/v1" @default.
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