Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362585026> ?p ?o ?g. }
- W4362585026 endingPage "1490" @default.
- W4362585026 startingPage "1490" @default.
- W4362585026 abstract "SGGY, an antioxidant tetrapeptide identified from walnut protein hydrolysate in our previous study, has been suggested to possess the potential to alleviate oxidative stress in cells. In this paper, the neuroprotective effects of SGGY on H2O2-stimulated oxidative stress in SH-SY5Y cells and the underlying mechanisms were investigated. Results showed that SGGY alleviated H2O2-induced oxidative stress by decreasing the intracellular reactive oxygen species (ROS) level and altering the mitochondrial membrane potential (MMP), thereby inhibiting apoptosis and increasing cell viability. SGGY significantly restored antioxidant enzyme activities and reduced malondialdehyde (MDA) content accordingly. Moreover, SGGY promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and suppressed the H2O2-induced activation of JNK and p38 mitogen-activated protein kinases (MAPKs). Taken together, these results suggested that SGGY protected SH-SY5Y cells from H2O2-provoked oxidative stress by enhancing the ability of cellular antioxidant defense, and the possible mechanism involved MAPKs and Nrf2 signaling pathways." @default.
- W4362585026 created "2023-04-06" @default.
- W4362585026 creator A5012995628 @default.
- W4362585026 creator A5027991472 @default.
- W4362585026 creator A5028009857 @default.
- W4362585026 creator A5059963751 @default.
- W4362585026 creator A5078659011 @default.
- W4362585026 creator A5079620701 @default.
- W4362585026 date "2023-04-01" @default.
- W4362585026 modified "2023-10-01" @default.
- W4362585026 title "Neuroprotective Effects of a Novel Tetrapeptide SGGY from Walnut against H2O2-Stimulated Oxidative Stress in SH-SY5Y Cells: Possible Involved JNK, p38 and Nrf2 Signaling Pathways" @default.
- W4362585026 cites W1651752646 @default.
- W4362585026 cites W2058096429 @default.
- W4362585026 cites W2066343151 @default.
- W4362585026 cites W2099818615 @default.
- W4362585026 cites W2286050125 @default.
- W4362585026 cites W2320862112 @default.
- W4362585026 cites W2464198397 @default.
- W4362585026 cites W2497981584 @default.
- W4362585026 cites W2510914029 @default.
- W4362585026 cites W2565489764 @default.
- W4362585026 cites W2574255351 @default.
- W4362585026 cites W2659467946 @default.
- W4362585026 cites W2787011902 @default.
- W4362585026 cites W2791513217 @default.
- W4362585026 cites W2794625128 @default.
- W4362585026 cites W2888299914 @default.
- W4362585026 cites W2902057351 @default.
- W4362585026 cites W2979806364 @default.
- W4362585026 cites W2998454304 @default.
- W4362585026 cites W3031244454 @default.
- W4362585026 cites W3134359042 @default.
- W4362585026 cites W3137589855 @default.
- W4362585026 cites W3165481569 @default.
- W4362585026 cites W3166483532 @default.
- W4362585026 cites W3194107530 @default.
- W4362585026 cites W3197770151 @default.
- W4362585026 cites W4206730390 @default.
- W4362585026 cites W4211211899 @default.
- W4362585026 cites W4213026749 @default.
- W4362585026 cites W4214644229 @default.
- W4362585026 cites W4220962616 @default.
- W4362585026 cites W4221142301 @default.
- W4362585026 cites W4223543013 @default.
- W4362585026 cites W4226251075 @default.
- W4362585026 cites W4282918083 @default.
- W4362585026 cites W4292288139 @default.
- W4362585026 cites W4296794005 @default.
- W4362585026 cites W4309241757 @default.
- W4362585026 cites W4309332487 @default.
- W4362585026 cites W4317038853 @default.
- W4362585026 cites W4321017972 @default.
- W4362585026 cites W4322741134 @default.
- W4362585026 doi "https://doi.org/10.3390/foods12071490" @default.
- W4362585026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37048311" @default.
- W4362585026 hasPublicationYear "2023" @default.
- W4362585026 type Work @default.
- W4362585026 citedByCount "1" @default.
- W4362585026 countsByYear W43625850262023 @default.
- W4362585026 crossrefType "journal-article" @default.
- W4362585026 hasAuthorship W4362585026A5012995628 @default.
- W4362585026 hasAuthorship W4362585026A5027991472 @default.
- W4362585026 hasAuthorship W4362585026A5028009857 @default.
- W4362585026 hasAuthorship W4362585026A5059963751 @default.
- W4362585026 hasAuthorship W4362585026A5078659011 @default.
- W4362585026 hasAuthorship W4362585026A5079620701 @default.
- W4362585026 hasBestOaLocation W43625850261 @default.
- W4362585026 hasConcept C184235292 @default.
- W4362585026 hasConcept C185592680 @default.
- W4362585026 hasConcept C190283241 @default.
- W4362585026 hasConcept C25498285 @default.
- W4362585026 hasConcept C2776151105 @default.
- W4362585026 hasConcept C2776715637 @default.
- W4362585026 hasConcept C2778004101 @default.
- W4362585026 hasConcept C2778401633 @default.
- W4362585026 hasConcept C2779083432 @default.
- W4362585026 hasConcept C2779281246 @default.
- W4362585026 hasConcept C2779564779 @default.
- W4362585026 hasConcept C48349386 @default.
- W4362585026 hasConcept C51551487 @default.
- W4362585026 hasConcept C53227056 @default.
- W4362585026 hasConcept C54355233 @default.
- W4362585026 hasConcept C55493867 @default.
- W4362585026 hasConcept C57074206 @default.
- W4362585026 hasConcept C57600042 @default.
- W4362585026 hasConcept C62478195 @default.
- W4362585026 hasConcept C81885089 @default.
- W4362585026 hasConcept C86803240 @default.
- W4362585026 hasConcept C95444343 @default.
- W4362585026 hasConcept C97029542 @default.
- W4362585026 hasConcept C98274493 @default.
- W4362585026 hasConceptScore W4362585026C184235292 @default.
- W4362585026 hasConceptScore W4362585026C185592680 @default.
- W4362585026 hasConceptScore W4362585026C190283241 @default.
- W4362585026 hasConceptScore W4362585026C25498285 @default.
- W4362585026 hasConceptScore W4362585026C2776151105 @default.
- W4362585026 hasConceptScore W4362585026C2776715637 @default.
- W4362585026 hasConceptScore W4362585026C2778004101 @default.