Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362587130> ?p ?o ?g. }
- W4362587130 endingPage "4494" @default.
- W4362587130 startingPage "4494" @default.
- W4362587130 abstract "Pterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 mg/kg, 300 mg/kg, or a commercial anti-inflammatory (15 mg/Kg, Ibuprofen) via gavage, daily, for three weeks. Ear edema was induced, and the animals were divided into five groups treated with: (i) ethanol, (ii) P. tridentatum, (iii) croton oil, (iv) croton oil + P. tridentatum, and (v) croton oil + medrol. The inflammatory effect was evaluated by the measurement of the knee and ear edema. The chromatographic profile, evaluated by HPLC-DAD, showed numerous phenolic compounds are present. In the docking analysis of these compounds, isoquercetin demonstrated strong molecular interactions for peroxisome proliferator-activated receptor alpha and gamma (PPARα and PPARƴ, respectively), protein kinase 2 subunit α (CK2 α), and 5-lipoxygenase-activating proteins. Genistein had strong docking binding energies for CK2α and prostaglandin H (2) synthase-1. Our analysis showed the treatment with P. tridentatum extract reversed OA-induced edema in the rat knee, as well as ear edema, highlights this plant as a potential source of compounds that can be used as adjuvants in the management of inflammation." @default.
- W4362587130 created "2023-04-06" @default.
- W4362587130 creator A5000019241 @default.
- W4362587130 creator A5000102651 @default.
- W4362587130 creator A5004445422 @default.
- W4362587130 creator A5010827688 @default.
- W4362587130 creator A5054245008 @default.
- W4362587130 creator A5058301078 @default.
- W4362587130 creator A5075681835 @default.
- W4362587130 date "2023-04-01" @default.
- W4362587130 modified "2023-10-16" @default.
- W4362587130 title "Anti-Inflammatory Effect of Pterospartum tridentatum Leaf Extract in Acute and Chronic Inflammation" @default.
- W4362587130 cites W1877755747 @default.
- W4362587130 cites W1965386867 @default.
- W4362587130 cites W1984643780 @default.
- W4362587130 cites W1989498585 @default.
- W4362587130 cites W1999155715 @default.
- W4362587130 cites W2008540071 @default.
- W4362587130 cites W2009288654 @default.
- W4362587130 cites W2012242544 @default.
- W4362587130 cites W2017663171 @default.
- W4362587130 cites W2020466729 @default.
- W4362587130 cites W2023321570 @default.
- W4362587130 cites W2031241152 @default.
- W4362587130 cites W2031349731 @default.
- W4362587130 cites W2038332233 @default.
- W4362587130 cites W2041449084 @default.
- W4362587130 cites W2056369910 @default.
- W4362587130 cites W2077332962 @default.
- W4362587130 cites W2080744985 @default.
- W4362587130 cites W2092118888 @default.
- W4362587130 cites W2105155030 @default.
- W4362587130 cites W2146166499 @default.
- W4362587130 cites W2150003043 @default.
- W4362587130 cites W2155715632 @default.
- W4362587130 cites W2171046955 @default.
- W4362587130 cites W2282124923 @default.
- W4362587130 cites W2384741127 @default.
- W4362587130 cites W2559418703 @default.
- W4362587130 cites W2613588137 @default.
- W4362587130 cites W2622401404 @default.
- W4362587130 cites W2752349915 @default.
- W4362587130 cites W2888459204 @default.
- W4362587130 cites W2917906958 @default.
- W4362587130 cites W2965048796 @default.
- W4362587130 cites W2993908729 @default.
- W4362587130 cites W3006045623 @default.
- W4362587130 cites W3009369454 @default.
- W4362587130 cites W3028868021 @default.
- W4362587130 cites W3031582282 @default.
- W4362587130 cites W3110779554 @default.
- W4362587130 cites W3144460164 @default.
- W4362587130 cites W3184058677 @default.
- W4362587130 cites W4205748791 @default.
- W4362587130 cites W4206904759 @default.
- W4362587130 doi "https://doi.org/10.3390/app13074494" @default.
- W4362587130 hasPublicationYear "2023" @default.
- W4362587130 type Work @default.
- W4362587130 citedByCount "1" @default.
- W4362587130 crossrefType "journal-article" @default.
- W4362587130 hasAuthorship W4362587130A5000019241 @default.
- W4362587130 hasAuthorship W4362587130A5000102651 @default.
- W4362587130 hasAuthorship W4362587130A5004445422 @default.
- W4362587130 hasAuthorship W4362587130A5010827688 @default.
- W4362587130 hasAuthorship W4362587130A5054245008 @default.
- W4362587130 hasAuthorship W4362587130A5058301078 @default.
- W4362587130 hasAuthorship W4362587130A5075681835 @default.
- W4362587130 hasBestOaLocation W43625871301 @default.
- W4362587130 hasConcept C126322002 @default.
- W4362587130 hasConcept C185592680 @default.
- W4362587130 hasConcept C2776914184 @default.
- W4362587130 hasConcept C2778261524 @default.
- W4362587130 hasConcept C2778942509 @default.
- W4362587130 hasConcept C2779703632 @default.
- W4362587130 hasConcept C2779944601 @default.
- W4362587130 hasConcept C2780886150 @default.
- W4362587130 hasConcept C556039675 @default.
- W4362587130 hasConcept C71924100 @default.
- W4362587130 hasConcept C98274493 @default.
- W4362587130 hasConceptScore W4362587130C126322002 @default.
- W4362587130 hasConceptScore W4362587130C185592680 @default.
- W4362587130 hasConceptScore W4362587130C2776914184 @default.
- W4362587130 hasConceptScore W4362587130C2778261524 @default.
- W4362587130 hasConceptScore W4362587130C2778942509 @default.
- W4362587130 hasConceptScore W4362587130C2779703632 @default.
- W4362587130 hasConceptScore W4362587130C2779944601 @default.
- W4362587130 hasConceptScore W4362587130C2780886150 @default.
- W4362587130 hasConceptScore W4362587130C556039675 @default.
- W4362587130 hasConceptScore W4362587130C71924100 @default.
- W4362587130 hasConceptScore W4362587130C98274493 @default.
- W4362587130 hasIssue "7" @default.
- W4362587130 hasLocation W43625871301 @default.
- W4362587130 hasLocation W43625871302 @default.
- W4362587130 hasOpenAccess W4362587130 @default.
- W4362587130 hasPrimaryLocation W43625871301 @default.
- W4362587130 hasRelatedWork W1978355472 @default.
- W4362587130 hasRelatedWork W2010270875 @default.
- W4362587130 hasRelatedWork W2058099622 @default.