Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362587948> ?p ?o ?g. }
- W4362587948 endingPage "6583" @default.
- W4362587948 startingPage "6583" @default.
- W4362587948 abstract "As emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (Omicron) continue to outpace and negate combinatorial vaccines and monoclonal antibody therapies targeting the spike protein (S) receptor binding domain (RBD), the appetite for developing similar COVID-19 treatments has significantly diminished, with the attention of the scientific community switching to long COVID treatments. However, treatments that reduce the risk of post-COVID-19 syndrome and associated sequelae remain in their infancy, particularly as no established criteria for diagnosis currently exist. Thus, alternative therapies that reduce infection and prevent the broad range of symptoms associated with 'post-COVID-19 syndrome' require investigation. This review begins with an overview of the parasitic-diarylamidine connection, followed by the renin-angiotensin system (RAS) and associated angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSSR2) involved in SARS-CoV-2 infection. Subsequently, the ability of diarylamidines to inhibit S-protein binding and various membrane serine proteases associated with SARS-CoV-2 and parasitic infections are discussed. Finally, the roles of diarylamidines (primarily DIZE) in vaccine efficacy, epigenetics, and the potential amelioration of long COVID sequelae are highlighted." @default.
- W4362587948 created "2023-04-06" @default.
- W4362587948 creator A5034851147 @default.
- W4362587948 date "2023-04-01" @default.
- W4362587948 modified "2023-10-18" @default.
- W4362587948 title "COVID-19 and Diarylamidines: The Parasitic Connection" @default.
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