Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362588843> ?p ?o ?g. }
- W4362588843 endingPage "295" @default.
- W4362588843 startingPage "295" @default.
- W4362588843 abstract "The aim of the present study was to obtain a hydrogel-based film as a carrier for the sustained and controlled release of vancomycin, an antibiotic commonly used in various types of infections. Considering the high-water solubility of vancomycin (>50 mg/mL) and the aqueous medium underlying the exudates, a prolonged release of vancomycin from an MCM-41 carrier was sought. The present work focused on the synthesis of malic acid coated magnetite (Fe3O4/malic) by co-precipitation, synthesis of MCM-41 by a sol-gel method and loading of MCM-41 with vancomycin, and their use in alginate films for wound dressing. The nanoparticles obtained were physically mixed and embedded in the alginate gel. Prior to incorporation, the nanoparticles were characterized by XRD, FT-IR and FT-Raman spectroscopy, TGA-DSC and DLS. The films were prepared by a simple casting method and were further cross-linked and examined for possible heterogeneities by means of FT-IR microscopy and SEM. The degree of swelling and the water vapor transmission rate were determined, considering their potential use as wound dressings. The obtained films show morpho-structural homogeneity, sustained release over 48 h and a strong synergistic enhancement of the antimicrobial activity as a consequence of the hybrid nature of these films. The antimicrobial efficacy was tested against S. aureus, two strains of E. faecalis (including vancomycin-resistant Enterococcus, VRE) and C. albicans. The incorporation of magnetite was also considered as an external triggering component in case the films were used as a magneto-responsive smart dressing to stimulate vancomycin diffusion." @default.
- W4362588843 created "2023-04-06" @default.
- W4362588843 creator A5014058583 @default.
- W4362588843 creator A5024792617 @default.
- W4362588843 creator A5027685617 @default.
- W4362588843 creator A5034236725 @default.
- W4362588843 creator A5040443584 @default.
- W4362588843 creator A5057113221 @default.
- W4362588843 creator A5074065195 @default.
- W4362588843 creator A5074581998 @default.
- W4362588843 creator A5080539204 @default.
- W4362588843 creator A5089830132 @default.
- W4362588843 date "2023-04-02" @default.
- W4362588843 modified "2023-10-18" @default.
- W4362588843 title "Synergistic Antimicrobial Activity of Magnetite and Vancomycin-Loaded Mesoporous Silica Embedded in Alginate Films" @default.
- W4362588843 cites W1972238564 @default.
- W4362588843 cites W2009588314 @default.
- W4362588843 cites W2065514037 @default.
- W4362588843 cites W2075580027 @default.
- W4362588843 cites W2082711698 @default.
- W4362588843 cites W2084740559 @default.
- W4362588843 cites W2142192815 @default.
- W4362588843 cites W2147038478 @default.
- W4362588843 cites W2164235461 @default.
- W4362588843 cites W2167558599 @default.
- W4362588843 cites W2168553430 @default.
- W4362588843 cites W2214607721 @default.
- W4362588843 cites W2234024148 @default.
- W4362588843 cites W2273253089 @default.
- W4362588843 cites W2330559824 @default.
- W4362588843 cites W2345621767 @default.
- W4362588843 cites W2560613844 @default.
- W4362588843 cites W2568209868 @default.
- W4362588843 cites W2588113915 @default.
- W4362588843 cites W2766332954 @default.
- W4362588843 cites W2777500385 @default.
- W4362588843 cites W2797241963 @default.
- W4362588843 cites W2799419454 @default.
- W4362588843 cites W2891844341 @default.
- W4362588843 cites W2904723369 @default.
- W4362588843 cites W2915401970 @default.
- W4362588843 cites W2943389432 @default.
- W4362588843 cites W2978459660 @default.
- W4362588843 cites W2979091381 @default.
- W4362588843 cites W2995234605 @default.
- W4362588843 cites W3001202973 @default.
- W4362588843 cites W3007098666 @default.
- W4362588843 cites W3020817947 @default.
- W4362588843 cites W3033842036 @default.
- W4362588843 cites W3034058167 @default.
- W4362588843 cites W3041530029 @default.
- W4362588843 cites W3043531817 @default.
- W4362588843 cites W3048894321 @default.
- W4362588843 cites W3083127221 @default.
- W4362588843 cites W3097690007 @default.
- W4362588843 cites W3115365311 @default.
- W4362588843 cites W3156963705 @default.
- W4362588843 cites W3176469487 @default.
- W4362588843 cites W3177178089 @default.
- W4362588843 cites W3185609741 @default.
- W4362588843 cites W3188347177 @default.
- W4362588843 cites W3196143957 @default.
- W4362588843 cites W3200881490 @default.
- W4362588843 cites W3203714633 @default.
- W4362588843 cites W3216447813 @default.
- W4362588843 cites W4200220189 @default.
- W4362588843 cites W4207062628 @default.
- W4362588843 cites W4210838158 @default.
- W4362588843 cites W4220779256 @default.
- W4362588843 cites W4229001585 @default.
- W4362588843 cites W4280556179 @default.
- W4362588843 cites W4285006817 @default.
- W4362588843 cites W4288722632 @default.
- W4362588843 cites W4291993637 @default.
- W4362588843 cites W4292566515 @default.
- W4362588843 cites W4293715074 @default.
- W4362588843 cites W4296919498 @default.
- W4362588843 cites W4306153397 @default.
- W4362588843 cites W4309002529 @default.
- W4362588843 cites W4309742742 @default.
- W4362588843 cites W4312196631 @default.
- W4362588843 doi "https://doi.org/10.3390/gels9040295" @default.
- W4362588843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102906" @default.
- W4362588843 hasPublicationYear "2023" @default.
- W4362588843 type Work @default.
- W4362588843 citedByCount "0" @default.
- W4362588843 crossrefType "journal-article" @default.
- W4362588843 hasAuthorship W4362588843A5014058583 @default.
- W4362588843 hasAuthorship W4362588843A5024792617 @default.
- W4362588843 hasAuthorship W4362588843A5027685617 @default.
- W4362588843 hasAuthorship W4362588843A5034236725 @default.
- W4362588843 hasAuthorship W4362588843A5040443584 @default.
- W4362588843 hasAuthorship W4362588843A5057113221 @default.
- W4362588843 hasAuthorship W4362588843A5074065195 @default.
- W4362588843 hasAuthorship W4362588843A5074581998 @default.
- W4362588843 hasAuthorship W4362588843A5080539204 @default.
- W4362588843 hasAuthorship W4362588843A5089830132 @default.
- W4362588843 hasBestOaLocation W43625888431 @default.