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• W4362589898 endingPage "131346" @default.
• W4362589898 startingPage "131346" @default.
• W4362589898 abstract "Styrene and ethylbenzene (S/EB) are hazardous pollutants that have attracted worldwide concern. In this prospective cohort study, S/EB exposure biomarker (the sum of mandelic acid and phenylglyoxylic acid [MA+PGA]) and fasting plasma glucose (FPG) were repeatedly measured three times. The polygenic risk score (PRS) based on 137 single nucleotide polymorphisms for type 2 diabetes mellitus (T2DM) was calculated to evaluate cumulative genetic effect. In repeated-measures cross-sectional analyses, MA+PGA (β [95% confidence interval]: 0.106 [0.022, 0.189]) and PRS (0.111 [0.047, 0.176]) were significantly related to FPG. For long-term effect assessment, participants with sustained high MA+PGA or with high PRS had 0.021 (95% CI: −0.398, 0.441) or 0.465 (0.064, 0.866) mmol/L increase in FPG, respectively, over 3 years follow-up, and had 0.256 (0.017, 0.494) or 0.265 (0.004, 0.527) mmol/L increase in FPG, respectively, over 6 years follow-up. We further detected a significant interaction effect between MA+PGA and PRS on FPG change, compared with participants with sustained low MA+PGA and low PRS, those with sustained high MA+PGA and high PRS had 0.778 (0.319, 1.258) mmol/L increase in FPG (P for interaction=0.028) over 6 years follow-up. Our study provides the first evidence that long-term exposure to S/EB potentially increases FPG, which might be aggravated by genetic susceptibility." @default.
• W4362589898 created "2023-04-06" @default.
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• W4362589898 date "2023-06-01" @default.
• W4362589898 modified "2023-10-14" @default.
• W4362589898 title "Long-term effect of styrene and ethylbenzene exposure on fasting plasma glucose: A gene-environment interaction study" @default.
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• W4362589898 doi "https://doi.org/10.1016/j.jhazmat.2023.131346" @default.
• W4362589898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37030230" @default.
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