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- W4362591293 abstract "Abstract Microenvironment is critical to the function of cells and organisms. One example is provided by biomolecular condensates, whose microenvironment can be vastly different from the surrounding cellular environments to engage unique biological functions. How microenvironments of biomolecular condensates affect their structure and function remains unknown. Here, we show that the arrangements and partitioning of biomolecules are dictated by the differences between the micropolarity of each subcompartment. Sufficient difference in micropolarity results in layered structures with the exterior shell presenting a more polar microenvironment than the interior core. Accordingly, micropolarity inversion is accompanied by conversions of the layered structures. These findings demonstrated the central role of the previously overlooked microenvironment in regulating the structural organization and function of membraneless organelles." @default.
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- W4362591293 date "2023-03-30" @default.
- W4362591293 modified "2023-09-26" @default.
- W4362591293 title "Micropolarity governs the structural organization of biomolecular condensates" @default.
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- W4362591293 doi "https://doi.org/10.1101/2023.03.30.534881" @default.
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