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- W4362600346 abstract "https://www.biorxiv.org/content/10.1101/2022.06.22.497080v1 Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a single cfDNA sample from cancer patients, an order of magnitude improvement over existing nanopore sequencing methods. We developed a single-molecule classifier to determine whether individual reads originated from a tumor or immune cells. Leveraging methylomes of matched tumors and immune cells, we characterized cfDNA methylomes of cancer patients for longitudinal monitoring during treatment." @default.
- W4362600346 created "2023-04-06" @default.
- W4362600346 creator A5043566220 @default.
- W4362600346 date "2023-04-04" @default.
- W4362600346 modified "2023-09-26" @default.
- W4362600346 title "High-throughput nanopore sequencing of cell-free DNA v1" @default.
- W4362600346 doi "https://doi.org/10.17504/protocols.io.4r3l27rjxg1y/v1" @default.
- W4362600346 hasPublicationYear "2023" @default.
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