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- W4362600372 abstract "Dendrites of fast-spiking basket cells (FS BCs) impact neural circuit functions in brain with both supralinear and sublinear integration strategies. Diverse spatial synaptic inputs and active properties of dendrites lead to distinct neuronal firing patterns. How the FS BCs with this bi-modal dendritic integration respond to different spatial dispersion of synaptic inputs remains unclear. In this study, we construct a multi-compartmental model of FS BC and analyze neuronal firings following simulated synaptic protocols from fully clustered to fully dispersed. Under these stimulation protocols, we find that supralinear dendrites dominate somatic firing of FS BC, while the preference for dispersing is due to sublinear dendrites. Moreover, we find that dendritic diameter and Ca2+-permeable AMPA conductance play an important role in it, while A-type K+ channel and NMDA conductance have little effect. The obtained results may give some implications for understanding dendritic computation." @default.
- W4362600372 created "2023-04-06" @default.
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- W4362600372 date "2023-04-04" @default.
- W4362600372 modified "2023-10-14" @default.
- W4362600372 title "Spatial integration of dendrites in fast-spiking basket cells" @default.
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- W4362600372 doi "https://doi.org/10.3389/fnins.2023.1132980" @default.
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