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- W4362601488 endingPage "e1010707" @default.
- W4362601488 startingPage "e1010707" @default.
- W4362601488 abstract "To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments. During spindle checkpoint activation, checkpoint proteins bind the unattached kinetochore and send a diffusible signal to inhibit the anaphase promoting complex/cyclosome (APC/C). Previous work has shown that mitotic cells with depolymerized microtubules can escape prolonged spindle checkpoint activation in a process called mitotic slippage. During slippage, spindle checkpoint proteins bind unattached kinetochores, but the cells cannot maintain the checkpoint arrest. We asked if meiotic cells had as robust of a spindle checkpoint response as mitotic cells and whether they also undergo slippage after prolonged spindle checkpoint activity. We performed a direct comparison between mitotic and meiotic budding yeast cells that signal the spindle checkpoint through two different assays. We find that the spindle checkpoint delay is shorter in meiosis I or meiosis II compared to mitosis, overcoming a checkpoint arrest approximately 150 minutes earlier in meiosis than in mitosis. In addition, cells in meiosis I escape spindle checkpoint signaling using two mechanisms, silencing the checkpoint at the kinetochore and through slippage. We propose that meiotic cells undertake developmentally-regulated mechanisms to prevent persistent spindle checkpoint activity to ensure the production of gametes." @default.
- W4362601488 created "2023-04-06" @default.
- W4362601488 creator A5017990671 @default.
- W4362601488 creator A5048792168 @default.
- W4362601488 creator A5080995431 @default.
- W4362601488 date "2023-04-05" @default.
- W4362601488 modified "2023-09-26" @default.
- W4362601488 title "Meiotic cells escape prolonged spindle checkpoint activity through kinetochore silencing and slippage" @default.
- W4362601488 cites W1568298288 @default.
- W4362601488 cites W1770540230 @default.
- W4362601488 cites W1822293882 @default.
- W4362601488 cites W1965016221 @default.
- W4362601488 cites W1965507216 @default.
- W4362601488 cites W1966072209 @default.
- W4362601488 cites W1966925645 @default.
- W4362601488 cites W1969264921 @default.
- W4362601488 cites W1969916685 @default.
- W4362601488 cites W1971799079 @default.
- W4362601488 cites W1971801697 @default.
- W4362601488 cites W1972204893 @default.
- W4362601488 cites W1974948367 @default.
- W4362601488 cites W1978668011 @default.
- W4362601488 cites W1983712701 @default.
- W4362601488 cites W1987402158 @default.
- W4362601488 cites W1990187458 @default.
- W4362601488 cites W1991119887 @default.
- W4362601488 cites W1992756342 @default.
- W4362601488 cites W1994672850 @default.
- W4362601488 cites W1995830988 @default.
- W4362601488 cites W1996991848 @default.
- W4362601488 cites W2002454928 @default.
- W4362601488 cites W2002538128 @default.
- W4362601488 cites W2009307035 @default.
- W4362601488 cites W2010442490 @default.
- W4362601488 cites W2015740282 @default.
- W4362601488 cites W2017956756 @default.
- W4362601488 cites W2020379884 @default.
- W4362601488 cites W2022501952 @default.
- W4362601488 cites W2023149393 @default.
- W4362601488 cites W2028511996 @default.
- W4362601488 cites W2033865457 @default.
- W4362601488 cites W2034086671 @default.
- W4362601488 cites W2035965664 @default.
- W4362601488 cites W2037533459 @default.
- W4362601488 cites W2039407046 @default.
- W4362601488 cites W2045533074 @default.
- W4362601488 cites W2046081805 @default.
- W4362601488 cites W2047521557 @default.
- W4362601488 cites W2048309959 @default.
- W4362601488 cites W2055141106 @default.
- W4362601488 cites W2055193421 @default.
- W4362601488 cites W2055743739 @default.
- W4362601488 cites W2059069459 @default.
- W4362601488 cites W2059605618 @default.
- W4362601488 cites W2060642930 @default.
- W4362601488 cites W2062077169 @default.
- W4362601488 cites W2062963733 @default.
- W4362601488 cites W2065196951 @default.
- W4362601488 cites W2068546621 @default.
- W4362601488 cites W2071110654 @default.
- W4362601488 cites W2073682421 @default.
- W4362601488 cites W2074578453 @default.
- W4362601488 cites W2081780560 @default.
- W4362601488 cites W2082162397 @default.
- W4362601488 cites W2084233021 @default.
- W4362601488 cites W2086690098 @default.
- W4362601488 cites W2090782595 @default.
- W4362601488 cites W2096801016 @default.
- W4362601488 cites W2106942695 @default.
- W4362601488 cites W2108626462 @default.
- W4362601488 cites W2108688550 @default.
- W4362601488 cites W2111902375 @default.
- W4362601488 cites W2111954050 @default.
- W4362601488 cites W2114460232 @default.
- W4362601488 cites W2116439730 @default.
- W4362601488 cites W2118390137 @default.
- W4362601488 cites W2133503471 @default.
- W4362601488 cites W2136675945 @default.
- W4362601488 cites W2143554677 @default.
- W4362601488 cites W2149895543 @default.
- W4362601488 cites W2153820061 @default.
- W4362601488 cites W2154046032 @default.
- W4362601488 cites W2155277330 @default.
- W4362601488 cites W2156091753 @default.
- W4362601488 cites W2161791847 @default.
- W4362601488 cites W2164366687 @default.
- W4362601488 cites W2167674042 @default.
- W4362601488 cites W2168405417 @default.
- W4362601488 cites W2169264075 @default.
- W4362601488 cites W2170145644 @default.
- W4362601488 cites W2171561067 @default.
- W4362601488 cites W2253629570 @default.
- W4362601488 cites W2339219040 @default.
- W4362601488 cites W2518888993 @default.
- W4362601488 cites W2571277506 @default.
- W4362601488 cites W2577471013 @default.
- W4362601488 cites W2613590953 @default.
- W4362601488 cites W2761213809 @default.