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• W4362606982 endingPage "348" @default.
• W4362606982 startingPage "335" @default.
• W4362606982 abstract "The rational design of small molecules that target specific DNA sequences is a promising strategy to modulate gene expression. This report focuses on a diamidinobenzimidazole compound, whose selective binding to the minor groove of AT DNA sequences holds broad significance in the molecular recognition of AT-rich human promoter sequences. The objective of this study is to provide a more detailed and systematized understanding, at an atomic level, of the molecular recognition mechanism of different AT-specific sequences by a rationally designed minor groove binder. The specialized method of X-ray crystallography was utilized to investigate how the sequence-dependent recognition properties in general, A-tract, and alternating AT sequences affect the binding of diamidinobenzimidazole in the DNA minor groove. While general and A-tract AT sequences give a narrower minor groove, the alternating AT sequences intrinsically have a wider minor groove which typically constricts upon binding. A strong and direct hydrogen bond between the N-H of the benzimidazole and an H-bond acceptor atom in the minor groove is essential for DNA recognition in all sequences described. In addition, the diamidine compound specifically utilizes an interfacial water molecule for its DNA binding. DNA complexes of AATT and AAAAAA recognition sites show that the diamidine compound can bind in two possible orientations with a preference for water-assisted hydrogen bonding at either cationic end. The complex structures of AAATTT, ATAT, ATATAT, and AAAA are bound in a singular orientation. Analysis of the helical parameters shows a minor groove expansion of about 1 Å across all the nonalternating DNA complexes. The results from this systematic approach will convey a greater understanding of the specific recognition of a diverse array of AT-rich sequences by small molecules and more insight into the design of small molecules with enhanced specificity to AT and mixed DNA sequences." @default.
• W4362606982 created "2023-04-06" @default.
• W4362606982 creator A5009204915 @default.
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• W4362606982 creator A5089679054 @default.
• W4362606982 date "2023-04-05" @default.
• W4362606982 modified "2023-09-26" @default.
• W4362606982 title "X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences" @default.
• W4362606982 cites W1515935592 @default.
• W4362606982 cites W1526944695 @default.
• W4362606982 cites W1583798044 @default.
• W4362606982 cites W1788240279 @default.
• W4362606982 cites W1833038589 @default.
• W4362606982 cites W1968591827 @default.
• W4362606982 cites W1972864160 @default.
• W4362606982 cites W1973363995 @default.
• W4362606982 cites W1975515814 @default.
• W4362606982 cites W1976499671 @default.
• W4362606982 cites W1980722147 @default.
• W4362606982 cites W1981036959 @default.
• W4362606982 cites W1985189558 @default.
• W4362606982 cites W1985982026 @default.
• W4362606982 cites W1994493918 @default.
• W4362606982 cites W2001543208 @default.
• W4362606982 cites W2008737360 @default.
• W4362606982 cites W2009690079 @default.
• W4362606982 cites W2010340383 @default.
• W4362606982 cites W2011475362 @default.
• W4362606982 cites W2011548771 @default.
• W4362606982 cites W2012627860 @default.
• W4362606982 cites W2015155457 @default.
• W4362606982 cites W2015688756 @default.
• W4362606982 cites W2023774467 @default.
• W4362606982 cites W2027749847 @default.
• W4362606982 cites W2029000151 @default.
• W4362606982 cites W2029962507 @default.
• W4362606982 cites W2034120148 @default.
• W4362606982 cites W2034555252 @default.
• W4362606982 cites W2036117391 @default.
• W4362606982 cites W2036272159 @default.
• W4362606982 cites W2041804048 @default.
• W4362606982 cites W2043339314 @default.
• W4362606982 cites W2047110397 @default.
• W4362606982 cites W2049685697 @default.
• W4362606982 cites W2050042672 @default.
• W4362606982 cites W2055200052 @default.
• W4362606982 cites W2065473716 @default.
• W4362606982 cites W2067174909 @default.
• W4362606982 cites W2069520341 @default.
• W4362606982 cites W2074907465 @default.
• W4362606982 cites W2077339476 @default.
• W4362606982 cites W2078514739 @default.
• W4362606982 cites W2079549728 @default.
• W4362606982 cites W2081468628 @default.
• W4362606982 cites W2083837363 @default.
• W4362606982 cites W2084850681 @default.
• W4362606982 cites W2088112805 @default.
• W4362606982 cites W2102537419 @default.
• W4362606982 cites W2106140689 @default.
• W4362606982 cites W2107029002 @default.
• W4362606982 cites W2108921801 @default.
• W4362606982 cites W2127933934 @default.
• W4362606982 cites W2129806608 @default.
• W4362606982 cites W2134967712 @default.
• W4362606982 cites W2141203396 @default.
• W4362606982 cites W2144081223 @default.
• W4362606982 cites W2147993766 @default.
• W4362606982 cites W2155557355 @default.
• W4362606982 cites W2165855161 @default.
• W4362606982 cites W2321353904 @default.
• W4362606982 cites W2326636678 @default.
• W4362606982 cites W2566930925 @default.
• W4362606982 cites W2751245942 @default.
• W4362606982 cites W2765264555 @default.
• W4362606982 cites W2766367793 @default.
• W4362606982 cites W2793989999 @default.
• W4362606982 cites W2799696102 @default.
• W4362606982 cites W2804695782 @default.
• W4362606982 cites W2884903051 @default.
• W4362606982 cites W2897941372 @default.
• W4362606982 cites W2910370732 @default.
• W4362606982 cites W2918672828 @default.
• W4362606982 cites W2973457155 @default.
• W4362606982 cites W3008871853 @default.
• W4362606982 cites W3082922101 @default.
• W4362606982 cites W3083406432 @default.
• W4362606982 cites W3093064317 @default.
• W4362606982 cites W3123805313 @default.
• W4362606982 cites W3209127187 @default.
• W4362606982 cites W4229591424 @default.
• W4362606982 cites W4281734708 @default.
• W4362606982 cites W4290672950 @default.
• W4362606982 cites W4313251759 @default.

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