Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362607029> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4362607029 abstract "BACKGROUND Resistant starch is a novel type of dietary fiber that can be considered as a natural polymer carrier with potential development prospects in the field of oral colonic release preparations since it can be degraded by bacteria in the large intestine. MATERIAL AND METHODS In this study, oral resistant starch-drug-loaded microspheres were prepared by spraydrying, and the response surface method was used to optimize the process based on the encapsulation efficiency. RESULTS The optimal preparation process conditions for the resistant starch-aspirin-loaded microspheres were as follows: core material: wall material ratio of 1: 1.98, chitosan solution concentration of 1.98%, and spray drying air inlet temperature of 130.45°C resulted in a reliable entrapment efficiency of 68.96%. Infrared spectroscopy analysis indicated that the encapsulated aspirin-starch microspheres did not differ significantly from the original resistant starch material. The ultrastructure of the drug-loaded microspheres was evenly wrapped with the capsule core and appeared as smooth spheres. The combination of resistant starch, aspirin, and chitosan resulted in a cross-linking reaction that reduced the overall gelatinization temperature compared with the original starch material alone. The light transmittance of the drug-loaded microspheres was slightly higher than that of the original resistant starch, while digestibility was similar to that of the resistant starch, indicating that the release would exist in the environment of the large intestine. CONCLUSIONS This study provides pivotal insights into the development of resistant starch in the field of colonic release preparations." @default.
- W4362607029 created "2023-04-06" @default.
- W4362607029 creator A5005471681 @default.
- W4362607029 creator A5021332443 @default.
- W4362607029 creator A5033798068 @default.
- W4362607029 creator A5045918068 @default.
- W4362607029 creator A5050889330 @default.
- W4362607029 creator A5072398440 @default.
- W4362607029 creator A5075318877 @default.
- W4362607029 creator A5085643062 @default.
- W4362607029 date "2023-03-29" @default.
- W4362607029 modified "2023-09-27" @default.
- W4362607029 title "Preparation, Physicochemical Properties, and Structural Characterization of Resistant Starch-Aspirin-Loaded Microspheres" @default.
- W4362607029 cites W1574786557 @default.
- W4362607029 cites W2023944428 @default.
- W4362607029 cites W2063276424 @default.
- W4362607029 cites W2162121962 @default.
- W4362607029 cites W2483886667 @default.
- W4362607029 cites W2494089358 @default.
- W4362607029 cites W2523650738 @default.
- W4362607029 cites W2606339806 @default.
- W4362607029 cites W2750073999 @default.
- W4362607029 cites W2753692261 @default.
- W4362607029 cites W2755795249 @default.
- W4362607029 cites W2763970606 @default.
- W4362607029 cites W2784033324 @default.
- W4362607029 cites W2800658254 @default.
- W4362607029 cites W2897063882 @default.
- W4362607029 cites W2897560548 @default.
- W4362607029 cites W2914348838 @default.
- W4362607029 cites W2922255118 @default.
- W4362607029 cites W2945985255 @default.
- W4362607029 cites W2953539822 @default.
- W4362607029 cites W2964142525 @default.
- W4362607029 cites W2991358839 @default.
- W4362607029 cites W2992401959 @default.
- W4362607029 cites W2995162439 @default.
- W4362607029 cites W3013764389 @default.
- W4362607029 cites W3033751161 @default.
- W4362607029 cites W3132851914 @default.
- W4362607029 cites W3150944538 @default.
- W4362607029 cites W3157616756 @default.
- W4362607029 cites W3167115350 @default.
- W4362607029 cites W3207291546 @default.
- W4362607029 cites W4221078420 @default.
- W4362607029 doi "https://doi.org/10.12659/msm.939711" @default.
- W4362607029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37231639" @default.
- W4362607029 hasPublicationYear "2023" @default.
- W4362607029 type Work @default.
- W4362607029 citedByCount "0" @default.
- W4362607029 crossrefType "journal-article" @default.
- W4362607029 hasAuthorship W4362607029A5005471681 @default.
- W4362607029 hasAuthorship W4362607029A5021332443 @default.
- W4362607029 hasAuthorship W4362607029A5033798068 @default.
- W4362607029 hasAuthorship W4362607029A5045918068 @default.
- W4362607029 hasAuthorship W4362607029A5050889330 @default.
- W4362607029 hasAuthorship W4362607029A5072398440 @default.
- W4362607029 hasAuthorship W4362607029A5075318877 @default.
- W4362607029 hasAuthorship W4362607029A5085643062 @default.
- W4362607029 hasBestOaLocation W43626070291 @default.
- W4362607029 hasConcept C127413603 @default.
- W4362607029 hasConcept C13965031 @default.
- W4362607029 hasConcept C185592680 @default.
- W4362607029 hasConcept C192562407 @default.
- W4362607029 hasConcept C2776633847 @default.
- W4362607029 hasConcept C2779732960 @default.
- W4362607029 hasConcept C2781228014 @default.
- W4362607029 hasConcept C31903555 @default.
- W4362607029 hasConcept C42360764 @default.
- W4362607029 hasConcept C529335014 @default.
- W4362607029 hasConcept C55493867 @default.
- W4362607029 hasConceptScore W4362607029C127413603 @default.
- W4362607029 hasConceptScore W4362607029C13965031 @default.
- W4362607029 hasConceptScore W4362607029C185592680 @default.
- W4362607029 hasConceptScore W4362607029C192562407 @default.
- W4362607029 hasConceptScore W4362607029C2776633847 @default.
- W4362607029 hasConceptScore W4362607029C2779732960 @default.
- W4362607029 hasConceptScore W4362607029C2781228014 @default.
- W4362607029 hasConceptScore W4362607029C31903555 @default.
- W4362607029 hasConceptScore W4362607029C42360764 @default.
- W4362607029 hasConceptScore W4362607029C529335014 @default.
- W4362607029 hasConceptScore W4362607029C55493867 @default.
- W4362607029 hasLocation W43626070291 @default.
- W4362607029 hasLocation W43626070292 @default.
- W4362607029 hasOpenAccess W4362607029 @default.
- W4362607029 hasPrimaryLocation W43626070291 @default.
- W4362607029 hasRelatedWork W2062550168 @default.
- W4362607029 hasRelatedWork W2145476261 @default.
- W4362607029 hasRelatedWork W2153507755 @default.
- W4362607029 hasRelatedWork W2352140761 @default.
- W4362607029 hasRelatedWork W2355982000 @default.
- W4362607029 hasRelatedWork W2357116428 @default.
- W4362607029 hasRelatedWork W2383979499 @default.
- W4362607029 hasRelatedWork W2771655317 @default.
- W4362607029 hasRelatedWork W3030718679 @default.
- W4362607029 hasRelatedWork W3183104864 @default.
- W4362607029 hasVolume "29" @default.
- W4362607029 isParatext "false" @default.
- W4362607029 isRetracted "false" @default.
- W4362607029 workType "article" @default.