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• W4362610030 abstract "<p>Supplementary Table 1. Apparent equilibrium binding constants (KD) as determined using flow cytometric methods for binding of MEDI6383 or MEDI6469 to activated human and NHP CD4 T cells or OX40-expressing Jurkat reporter cells, as indicated; Supplementary Table 2. Comparative bioactivity of MEDI6383 and MEDI6469 in 2-cell bioassays using CD32B-expressing HEK cells or Raji B cells for drug clustering and OX40-expressing Jurkat NFKB luciferase reporter cells for activity readout as described in the text; Supplementary Table 3. Affinity/avidity equilibrium binding constants (KD) for MEDI6383 or a human IgG1 version of MEDI6383 where the human IgG4 Fc domains were replaced by human IgG1 Fc domains to human or cyno Fc gamma receptors (FcγR), as indicated.</p>" @default.
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• W4362610030 date "2023-04-03" @default.
• W4362610030 modified "2023-09-27" @default.
• W4362610030 title "Supplementary Tables 1-3 from Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein" @default.
• W4362610030 doi "https://doi.org/10.1158/1535-7163.22505518" @default.
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