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- W4362630758 abstract "<p>Supplementary Figure S4. Additional data supporting Figure 6. In the I/V model, BALB/c mice were administered 100k CT26 cells and treated when tumors reached a size of 40mm3 with isotype (I) or anti-VISTA (V). In the CPV model, BALB/c mice were administered 100k CT26 cells and treated with anti-CTLA-4 and anti-PD-1 plus isotype (CP) or plus anti-VISTA (CPV) when tumors reached a size of 600mm3. CD45 + (A-C, E) or CD8+ AH1-tetramer+ (D) cells were isolated from the TME and analyzed by scRNAseq. (A) Stacked bar graph showing all lymphoid cluster frequencies as a proportion of the lymphoid infiltrate for I/V and CP/CPV. (B) Stacked bar graph showing NK cluster frequencies as a proportion of the NK infiltrate for I/V and CP/CPV. (C) Stacked bar graph showing CD8+ T cell cluster frequencies as a proportion of the CD8+ T cell infiltrate for I/V and CP/CPV. (D) Mean cluster frequencies as a proportion of CD8+ AH1-tetramer+ T cells in I/V or CP/CPV treatment. (E) Violin plots showing enrichment of a quiescence gene signature in CD8+ T cell clusters in the CD45 + sorted I/V dataset[58]. *P < 0.05, **P < 0.01, ***P < 0.001.</p>" @default.
- W4362630758 created "2023-04-07" @default.
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- W4362630758 date "2023-04-04" @default.
- W4362630758 modified "2023-09-27" @default.
- W4362630758 title "Figure S4 from VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance" @default.
- W4362630758 doi "https://doi.org/10.1158/2326-6066.22546460.v1" @default.
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