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• W4362634175 endingPage "106113" @default.
• W4362634175 startingPage "106113" @default.
• W4362634175 abstract "Multiple sclerosis (MS), a chronic auto-immune, inflammatory, and degenerative disease of the central nervous system, affects both males and females; however, females suffer from a higher risk of developing MS (2-3:1 ratio relative to males). The precise sex-based factors influencing risk of MS are currently unknown. Here, we explore the role of sex in MS to identify molecular mechanisms underlying observed MS sex differences that may guide novel therapeutic approaches tailored for males or females.We performed a rigorous and systematic review of genome-wide transcriptome studies of MS that included patient sex data in the Gene Expression Omnibus and ArrayExpress databases following PRISMA statement guidelines. For each selected study, we analyzed differential gene expression to explore the impact of the disease in females (IDF), in males (IDM) and our main goal: the sex differential impact of the disease (SDID). Then, for each scenario (IDF, IDM and SDID) we performed 2 meta-analyses in the main tissues involved in the disease (brain and blood). Finally, we performed a gene set analysis in brain tissue, in which a higher number of genes were dysregulated, to characterize sex differences in biological pathways.After screening 122 publications, the systematic review provided a selection of 9 studies (5 in blood and 4 in brain tissue) with a total of 474 samples (189 females with MS and 109 control females; 82 males with MS and 94 control males). Blood and brain tissue meta-analyses identified, respectively, 1 (KIR2DL3) and 13 (ARL17B, CECR7, CEP78, IFFO2, LOC401127, NUDT18, RNF10, SLC17A5, STMP1, TRAF3IP2-AS1, UBXN2B, ZNF117, ZNF488) MS-associated genes that differed between males and females (SDID comparison). Functional analyses in the brain revealed different altered immune patterns in females and males (IDF and IDM comparisons). The pro-inflammatory environment and innate immune responses related to myeloid lineage appear to be more affected in females, while adaptive responses associated with the lymphocyte lineage in males. Additionally, females with MS displayed alterations in mitochondrial respiratory chain complexes, purine, and glutamate metabolism, while MS males displayed alterations in stress response to metal ion, amine, and amino acid transport.We found transcriptomic and functional differences between MS males and MS females (especially in the immune system), which may support the development of new sex-based research of this disease. Our study highlights the importance of understanding the role of biological sex in MS to guide a more personalized medicine." @default.
• W4362634175 created "2023-04-07" @default.
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• W4362634175 date "2023-06-01" @default.
• W4362634175 modified "2023-10-15" @default.
• W4362634175 title "A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis" @default.
• W4362634175 cites W1596515083 @default.
• W4362634175 cites W1868313151 @default.
• W4362634175 cites W1967291818 @default.
• W4362634175 cites W1984919162 @default.
• W4362634175 cites W1985987855 @default.
• W4362634175 cites W1986634150 @default.
• W4362634175 cites W1986642062 @default.
• W4362634175 cites W2017568647 @default.
• W4362634175 cites W2027431314 @default.
• W4362634175 cites W2039782279 @default.
• W4362634175 cites W2042551060 @default.
• W4362634175 cites W2043558032 @default.
• W4362634175 cites W2047611848 @default.
• W4362634175 cites W2048417169 @default.
• W4362634175 cites W2063819412 @default.
• W4362634175 cites W2075571835 @default.
• W4362634175 cites W2080401298 @default.
• W4362634175 cites W2082026429 @default.
• W4362634175 cites W2085893043 @default.
• W4362634175 cites W2103017472 @default.
• W4362634175 cites W2107328434 @default.
• W4362634175 cites W2112289496 @default.
• W4362634175 cites W2113693040 @default.
• W4362634175 cites W2118258530 @default.
• W4362634175 cites W2118525500 @default.
• W4362634175 cites W2120620347 @default.
• W4362634175 cites W2124598377 @default.
• W4362634175 cites W2130410032 @default.
• W4362634175 cites W2132813105 @default.
• W4362634175 cites W2139168999 @default.
• W4362634175 cites W2140780616 @default.
• W4362634175 cites W2146512944 @default.
• W4362634175 cites W2160569592 @default.
• W4362634175 cites W2196530082 @default.
• W4362634175 cites W2212388061 @default.
• W4362634175 cites W2221301078 @default.
• W4362634175 cites W2244160451 @default.
• W4362634175 cites W2302501749 @default.
• W4362634175 cites W2334765794 @default.
• W4362634175 cites W2338829975 @default.
• W4362634175 cites W2409272355 @default.
• W4362634175 cites W2518536270 @default.
• W4362634175 cites W2531382661 @default.
• W4362634175 cites W2559792736 @default.
• W4362634175 cites W2731745392 @default.
• W4362634175 cites W2765652082 @default.
• W4362634175 cites W2772227551 @default.
• W4362634175 cites W2777812161 @default.
• W4362634175 cites W2781107974 @default.
• W4362634175 cites W2782297377 @default.
• W4362634175 cites W2783373090 @default.
• W4362634175 cites W2791128115 @default.
• W4362634175 cites W2792318576 @default.
• W4362634175 cites W2792558135 @default.
• W4362634175 cites W2797170123 @default.
• W4362634175 cites W2800750353 @default.
• W4362634175 cites W2806777665 @default.
• W4362634175 cites W2896014118 @default.
• W4362634175 cites W2898321887 @default.
• W4362634175 cites W2911253994 @default.
• W4362634175 cites W2921234203 @default.
• W4362634175 cites W2950148918 @default.
• W4362634175 cites W2953757801 @default.
• W4362634175 cites W2966549733 @default.
• W4362634175 cites W2967521908 @default.
• W4362634175 cites W2980051151 @default.
• W4362634175 cites W2992891056 @default.
• W4362634175 cites W2995009516 @default.
• W4362634175 cites W2997458121 @default.
• W4362634175 cites W3001092422 @default.
• W4362634175 cites W3008780596 @default.
• W4362634175 cites W3012283572 @default.
• W4362634175 cites W3015693380 @default.
• W4362634175 cites W3043003617 @default.
• W4362634175 cites W3083889688 @default.
• W4362634175 cites W3087322509 @default.
• W4362634175 cites W3096568637 @default.
• W4362634175 cites W3106143834 @default.
• W4362634175 cites W3120644234 @default.
• W4362634175 cites W3123862515 @default.
• W4362634175 cites W3137946327 @default.
• W4362634175 cites W3153488936 @default.

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