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• W4362636161 abstract "Neural crest cells along the body axis of avian embryos differ in their developmental potential, such that the cranial neural crest forms cartilage and bone whereas the trunk neural crest is unable to do so. Previous studies have identified a cranial crest-specific subcircuit that can imbue the trunk neural crest with the ability to form cartilage after grafting to the head. Here, we examine transcriptional and cell fate changes that accompany this reprogramming. First, we examined whether reprogrammed trunk neural crest maintain the ability to form cartilage in their endogenous environment in the absence of cues from the head. The results show that some reprogrammed cells contribute to normal trunk neural crest derivatives, whereas others migrate ectopically to the forming vertebrae and express cartilage markers, thus mimicking heterotypically transplanted cranial crest cells. We find that reprogrammed trunk neural crest upregulated more than 3000 genes in common with cranial neural crest, including numerous transcriptional regulators. In contrast, many trunk neural crest genes are downregulated. Together, our findings show that reprogramming trunk neural crest with cranial crest subcircuit genes alters their gene regulatory program and developmental potential to be more cranial crest-like." @default.
• W4362636161 created "2023-04-07" @default.
• W4362636161 creator A5019521298 @default.
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• W4362636161 date "2023-05-01" @default.
• W4362636161 modified "2023-10-12" @default.
• W4362636161 title "Reprogramming of trunk neural crest to a cranial crest-like identity alters their transcriptome and developmental potential" @default.
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• W4362636161 doi "https://doi.org/10.1016/j.diff.2023.04.001" @default.
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• W4362636161 hasPublicationYear "2023" @default.
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