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- W4362636248 abstract "Parkinson's disease (PD) affects cortical structures and neurophysiology. How these deviations from normative variants relate to the neurochemical systems of the cortex in a manner corresponding to motor and cognitive symptoms is unknown. We measured cortical thickness and spectral neurophysiological alterations from structural magnetic resonance imaging and task-free magnetoencephalography in patients with idiopathic PD (N MEG = 79; N MRI = 65), contrasted with similar data from matched healthy controls (N MEG = 65; N MRI = 37). Using linear mixed-effects models and cortical atlases of 19 neurochemical systems, we found that the structural and neurophysiological alterations of PD align with several receptor and transporter systems (acetylcholine, serotonin, glutamate, and noradrenaline) albeit with different implications for motor and non-motor symptoms. Some neurophysiological alignments are protective of cognitive functions: the alignment of broadband power increases with acetylcholinergic systems is related to better attention function. However, neurochemical alignment with structural and other neurophysiological alterations is associated with motor and psychiatric impairments, respectively. Collectively, the present data advance understanding of the association between the nature of neurophysiological and structural cortical alterations in PD and the symptoms that are characteristic of the disease. They also demonstrate the value of a new nested atlas modeling approach to advance research on neurological and neuropsychiatric diseases." @default.
- W4362636248 created "2023-04-07" @default.
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- W4362636248 date "2023-04-05" @default.
- W4362636248 modified "2023-09-24" @default.
- W4362636248 title "Structural and neurophysiological alterations in Parkinson's disease are aligned with cortical neurochemical systems" @default.
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- W4362636248 doi "https://doi.org/10.1101/2023.04.04.23288137" @default.
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