Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362636670> ?p ?o ?g. }
- W4362636670 abstract "People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response.We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography-coupled mass spectrometry (GC-MS).We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanol-treated animals: uracil, succinate, proline, nicotinamide, and tyrosine.Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system." @default.
- W4362636670 created "2023-04-07" @default.
- W4362636670 creator A5001897128 @default.
- W4362636670 creator A5006902529 @default.
- W4362636670 creator A5013977089 @default.
- W4362636670 creator A5029441169 @default.
- W4362636670 creator A5039830006 @default.
- W4362636670 creator A5044175711 @default.
- W4362636670 creator A5046720929 @default.
- W4362636670 creator A5052044213 @default.
- W4362636670 creator A5055766482 @default.
- W4362636670 creator A5057582239 @default.
- W4362636670 creator A5058817352 @default.
- W4362636670 creator A5068069505 @default.
- W4362636670 creator A5075639505 @default.
- W4362636670 creator A5077359876 @default.
- W4362636670 creator A5082359288 @default.
- W4362636670 date "2023-04-05" @default.
- W4362636670 modified "2023-10-12" @default.
- W4362636670 title "Chronic alcohol administration alters metabolomic profile of murine bone marrow" @default.
- W4362636670 cites W1761787460 @default.
- W4362636670 cites W1941065178 @default.
- W4362636670 cites W1970353720 @default.
- W4362636670 cites W1995333955 @default.
- W4362636670 cites W2001378762 @default.
- W4362636670 cites W2001630726 @default.
- W4362636670 cites W2002591374 @default.
- W4362636670 cites W2006132019 @default.
- W4362636670 cites W2006864860 @default.
- W4362636670 cites W2016341284 @default.
- W4362636670 cites W2016689874 @default.
- W4362636670 cites W2032703707 @default.
- W4362636670 cites W2058944086 @default.
- W4362636670 cites W2074824347 @default.
- W4362636670 cites W2080274549 @default.
- W4362636670 cites W2089532303 @default.
- W4362636670 cites W2105265356 @default.
- W4362636670 cites W2121470796 @default.
- W4362636670 cites W2122938990 @default.
- W4362636670 cites W2126958674 @default.
- W4362636670 cites W2132727567 @default.
- W4362636670 cites W2144821195 @default.
- W4362636670 cites W2148692544 @default.
- W4362636670 cites W2149042080 @default.
- W4362636670 cites W2157677850 @default.
- W4362636670 cites W2171900160 @default.
- W4362636670 cites W2193530123 @default.
- W4362636670 cites W2326156400 @default.
- W4362636670 cites W2375376029 @default.
- W4362636670 cites W2519230103 @default.
- W4362636670 cites W2551342304 @default.
- W4362636670 cites W2604693432 @default.
- W4362636670 cites W2611694282 @default.
- W4362636670 cites W2614822513 @default.
- W4362636670 cites W2635415917 @default.
- W4362636670 cites W2742914980 @default.
- W4362636670 cites W2744970765 @default.
- W4362636670 cites W2781490247 @default.
- W4362636670 cites W2891826366 @default.
- W4362636670 cites W2896924075 @default.
- W4362636670 cites W2908854378 @default.
- W4362636670 cites W2916029362 @default.
- W4362636670 cites W2919308974 @default.
- W4362636670 cites W2938876428 @default.
- W4362636670 cites W2949358699 @default.
- W4362636670 cites W2955084980 @default.
- W4362636670 cites W2981891326 @default.
- W4362636670 cites W3008970895 @default.
- W4362636670 cites W3045244793 @default.
- W4362636670 cites W3092047360 @default.
- W4362636670 cites W3183259062 @default.
- W4362636670 cites W3198264909 @default.
- W4362636670 cites W4230119926 @default.
- W4362636670 cites W4293155746 @default.
- W4362636670 doi "https://doi.org/10.3389/fimmu.2023.1128352" @default.
- W4362636670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37090737" @default.
- W4362636670 hasPublicationYear "2023" @default.
- W4362636670 type Work @default.
- W4362636670 citedByCount "0" @default.
- W4362636670 crossrefType "journal-article" @default.
- W4362636670 hasAuthorship W4362636670A5001897128 @default.
- W4362636670 hasAuthorship W4362636670A5006902529 @default.
- W4362636670 hasAuthorship W4362636670A5013977089 @default.
- W4362636670 hasAuthorship W4362636670A5029441169 @default.
- W4362636670 hasAuthorship W4362636670A5039830006 @default.
- W4362636670 hasAuthorship W4362636670A5044175711 @default.
- W4362636670 hasAuthorship W4362636670A5046720929 @default.
- W4362636670 hasAuthorship W4362636670A5052044213 @default.
- W4362636670 hasAuthorship W4362636670A5055766482 @default.
- W4362636670 hasAuthorship W4362636670A5057582239 @default.
- W4362636670 hasAuthorship W4362636670A5058817352 @default.
- W4362636670 hasAuthorship W4362636670A5068069505 @default.
- W4362636670 hasAuthorship W4362636670A5075639505 @default.
- W4362636670 hasAuthorship W4362636670A5077359876 @default.
- W4362636670 hasAuthorship W4362636670A5082359288 @default.
- W4362636670 hasBestOaLocation W43626366701 @default.
- W4362636670 hasConcept C109159458 @default.
- W4362636670 hasConcept C135870905 @default.
- W4362636670 hasConcept C181199279 @default.
- W4362636670 hasConcept C185592680 @default.