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- W4362637175 abstract "Single-cell technologies have revealed the extensive heterogeneity and complexity of the immune system. Systems biology approaches in immunology have taken advantage of the high-parameter, high-throughput data and analyzed immune cell types in a ‘bottom-up’ data-driven method. This approach has discovered previously unrecognized cell types and functions. Especially for human immunology, in which experimental manipulations are challenging, systems approach has become a successful means to investigate physiologically relevant contexts. This review focuses on the recent findings in lymphocyte biology, from their development, differentiation into subsets, and heterogeneity in their functions, enabled by these systems approaches. Furthermore, we review examples of the application of findings from systems approach studies and discuss how now to leave the rich dataset in the curse of high dimensionality." @default.
- W4362637175 created "2023-04-07" @default.
- W4362637175 creator A5045383208 @default.
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- W4362637175 creator A5080718903 @default.
- W4362637175 date "2023-06-01" @default.
- W4362637175 modified "2023-10-11" @default.
- W4362637175 title "Systems biology approaches to unravel lymphocyte subsets and function" @default.
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- W4362637175 doi "https://doi.org/10.1016/j.coi.2023.102323" @default.
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