FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362657549> ?p ?o ?g. }

• W4362657549 endingPage "958" @default.
• W4362657549 startingPage "948" @default.
• W4362657549 abstract "Replication-dependent histones have a stem-loop structure at the 3′ end of messenger RNA (mRNA) and are stabilized by stem-loop binding protein (SLBP). Moreover, loss of SLBP and imbalance in the level of ARE (adenylate-uridylate-rich elements)-binding proteins, HuR, and BRF1 are associated with the polyadenylation of canonical histone mRNAs under different physiological conditions. Previous studies from the lab have shown increased protein levels of H2A1H and H3.2 in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma (HCC). In this study, we report that increase in the polyadenylation of histone mRNA contributes to increased levels of H2A1H and H3.2 in NDEA-induced HCC. The persistent exposure to carcinogen with polyadenylation of histone mRNA increases the total histone pool resulting in aneuploidy. The embryonic liver has also shown increased polyadenylated histone isoforms, Hist1h2ah and Hist2h3c2, primarily contributing to their increased protein levels. The increase in polyadenylation of histone mRNA in HCC and e15 are in coherence with the decrease in SLBP and BRF1 with an increase in HuR. Our studies in neoplastic CL38 cell line showed that direct stress on the cells induces downregulation of SLBP with enhanced histone isoform polyadenylation. Moreover, the polyadenylation is related to increase in activated MAP kinases, p38, ERK, and JNK in HCC liver tumor tissues and CL38 cells treated with arsenic. Our data suggest that SLBP degrades under stress, destabilizing the stem-loop, elongating histone isoforms mRNA with 3′ polyadenylated tail with increase of HuR and decrease of BRF1. Overall, our results indicate that SLBP may play an essential part in cell proliferation, at least in persistent exposure to stress, by mediating the stabilization of histone isoforms throughout the cell cycle." @default.
• W4362657549 created "2023-04-07" @default.
• W4362657549 creator A5017407196 @default.
• W4362657549 creator A5060074395 @default.
• W4362657549 creator A5061113138 @default.
• W4362657549 creator A5077953523 @default.
• W4362657549 creator A5079206652 @default.
• W4362657549 date "2023-04-06" @default.
• W4362657549 modified "2023-10-08" @default.
• W4362657549 title "An increase in polyadenylation of histone isoforms, Hist1h2ah and Hist2h3c2, is governed by 3′-UTR in de-differentiated and undifferentiated hepatocyte" @default.
• W4362657549 cites W1828888489 @default.
• W4362657549 cites W1993691900 @default.
• W4362657549 cites W1997362916 @default.
• W4362657549 cites W2001973462 @default.
• W4362657549 cites W2012036589 @default.
• W4362657549 cites W2024845297 @default.
• W4362657549 cites W2032864127 @default.
• W4362657549 cites W2035282314 @default.
• W4362657549 cites W2039298735 @default.
• W4362657549 cites W2040493537 @default.
• W4362657549 cites W2051778673 @default.
• W4362657549 cites W2059591102 @default.
• W4362657549 cites W2059646461 @default.
• W4362657549 cites W2059978499 @default.
• W4362657549 cites W2061223956 @default.
• W4362657549 cites W2065530211 @default.
• W4362657549 cites W2082066702 @default.
• W4362657549 cites W2086606897 @default.
• W4362657549 cites W2103299450 @default.
• W4362657549 cites W2113569709 @default.
• W4362657549 cites W2114191896 @default.
• W4362657549 cites W2144452612 @default.
• W4362657549 cites W2152859477 @default.
• W4362657549 cites W2489181586 @default.
• W4362657549 cites W2518727093 @default.
• W4362657549 cites W258686985 @default.
• W4362657549 cites W2596650598 @default.
• W4362657549 cites W2766521066 @default.
• W4362657549 cites W2782627618 @default.
• W4362657549 cites W2791538534 @default.
• W4362657549 cites W2794530843 @default.
• W4362657549 cites W2806425638 @default.
• W4362657549 cites W2897628717 @default.
• W4362657549 cites W2936091015 @default.
• W4362657549 cites W2939928936 @default.
• W4362657549 cites W2969433899 @default.
• W4362657549 cites W3000532606 @default.
• W4362657549 cites W3081991675 @default.
• W4362657549 cites W3201919436 @default.
• W4362657549 cites W4225529913 @default.
• W4362657549 doi "https://doi.org/10.1177/15353702231160328" @default.
• W4362657549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37021545" @default.
• W4362657549 hasPublicationYear "2023" @default.
• W4362657549 type Work @default.
• W4362657549 citedByCount "0" @default.
• W4362657549 crossrefType "journal-article" @default.
• W4362657549 hasAuthorship W4362657549A5017407196 @default.
• W4362657549 hasAuthorship W4362657549A5060074395 @default.
• W4362657549 hasAuthorship W4362657549A5061113138 @default.
• W4362657549 hasAuthorship W4362657549A5077953523 @default.
• W4362657549 hasAuthorship W4362657549A5079206652 @default.
• W4362657549 hasConcept C104317684 @default.
• W4362657549 hasConcept C105580179 @default.
• W4362657549 hasConcept C142575336 @default.
• W4362657549 hasConcept C153911025 @default.
• W4362657549 hasConcept C2776745794 @default.
• W4362657549 hasConcept C53345823 @default.
• W4362657549 hasConcept C55493867 @default.
• W4362657549 hasConcept C64927066 @default.
• W4362657549 hasConcept C86803240 @default.
• W4362657549 hasConcept C89604277 @default.
• W4362657549 hasConceptScore W4362657549C104317684 @default.
• W4362657549 hasConceptScore W4362657549C105580179 @default.
• W4362657549 hasConceptScore W4362657549C142575336 @default.
• W4362657549 hasConceptScore W4362657549C153911025 @default.
• W4362657549 hasConceptScore W4362657549C2776745794 @default.
• W4362657549 hasConceptScore W4362657549C53345823 @default.
• W4362657549 hasConceptScore W4362657549C55493867 @default.
• W4362657549 hasConceptScore W4362657549C64927066 @default.
• W4362657549 hasConceptScore W4362657549C86803240 @default.
• W4362657549 hasConceptScore W4362657549C89604277 @default.
• W4362657549 hasIssue "11" @default.
• W4362657549 hasLocation W43626575491 @default.
• W4362657549 hasLocation W43626575492 @default.
• W4362657549 hasOpenAccess W4362657549 @default.
• W4362657549 hasPrimaryLocation W43626575491 @default.
• W4362657549 hasRelatedWork W1535356260 @default.
• W4362657549 hasRelatedWork W1966740287 @default.
• W4362657549 hasRelatedWork W1979133937 @default.
• W4362657549 hasRelatedWork W2019107363 @default.
• W4362657549 hasRelatedWork W2073461718 @default.
• W4362657549 hasRelatedWork W2434831725 @default.
• W4362657549 hasRelatedWork W2522433653 @default.
• W4362657549 hasRelatedWork W2773320331 @default.
• W4362657549 hasRelatedWork W2790178665 @default.
• W4362657549 hasRelatedWork W4291964159 @default.
• W4362657549 hasVolume "248" @default.
• W4362657549 isParatext "false" @default.

• next