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• W4362657957 abstract "Adenosine triphosphate (ATP) is the major resource of energy supply in tumor activity. Therefore, improving ATP consumption efficiencies is a promising approach for cancer therapy. Herein, inspired by the H2O2-involved structure regulation effect during the catalysis of natural protein enzymes, we developed an artificial H2O2-driven ATP catalysis-promoting system, the Ce-based metal–organic framework (Ce-MOF), for catalytic cancer therapy. In the presence of H2O2, the hydrolysis ATP activity of Ce-MOF(H2O2) was enhanced by around 1.6 times. Taking advantage of the endogenous H2O2 in cancerous cells, catalytic hydrolysis for intracellular ATP of the Ce-MOF achieves the inhibition of cancerous cell growth, which involves damaged mitochondrial function and autophagy-associated cell death. Furthermore, in vivo studies suggest that the Ce-MOF has a good tumor inhibition effect. The artificial H2O2-driven ATP catalysis-promoting system not only demonstrates high catalytic ATP consumption efficiencies for cancer therapy but also highlights a bioinspired strategy to expedite nanozyme research in both design and applied sciences." @default.
• W4362657957 created "2023-04-07" @default.
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• W4362657957 date "2023-04-06" @default.
• W4362657957 modified "2023-10-16" @default.
• W4362657957 title "Bioinspired Structure Regulation of Apyrase-Like Nanozyme with Intracellular-Generated H₂O₂ for Tumor Catalytic Therapy" @default.
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• W4362657957 doi "https://doi.org/10.1021/acsami.3c00720" @default.
• W4362657957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37023051" @default.
• W4362657957 hasPublicationYear "2023" @default.
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