FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362658347> ?p ?o ?g. }

• W4362658347 abstract "Nonalcoholic fatty liver disease (NAFLD), which leads to insulin resistance, steatosis, and even hepatocellular carcinoma, is the most common chronic liver disease worldwide, however, effective treatment is still lacking. This study determined the role of liver FGF21 and the mechanisms underlying the protective effects of time-restricted feeding (TRF) in NAFLD. FGF21 liver knockout (FGF21 LKO) mice and C57BL/6 wild-type (WT) mice were fed either a normal or a high-fat diet (HFD) for 16 weeks. Mice with diet-induced obesity (DIO) were also used. The mice were fed either ad libitum or in a time-restricted manner. Serum FGF21 levels were significantly increased after 16 weeks of TRF. TRF prevented body weight gain, improved glucose homeostasis, and protected against high-fat diet-induced hepatosteatosis and liver damage. The expression of genes related to liver lipogenesis and inflammation was reduced in TRF mice, but the expression of genes involved in fatty acid β-oxidation was increased. However, those beneficial effects of TRF were blunted in the FGF21 LKO mice. Moreover, TRF promoted improvements in insulin sensitivity and liver damage in DIO mice. Our data show that liver FGF21 signaling was involved in the effect of TRF on high-fat diet-induced fatty liver." @default.
• W4362658347 created "2023-04-07" @default.
• W4362658347 creator A5001478855 @default.
• W4362658347 creator A5012677271 @default.
• W4362658347 creator A5027046605 @default.
• W4362658347 creator A5032457463 @default.
• W4362658347 creator A5038497872 @default.
• W4362658347 creator A5048025320 @default.
• W4362658347 creator A5052883326 @default.
• W4362658347 creator A5053678004 @default.
• W4362658347 creator A5060742506 @default.
• W4362658347 creator A5068306950 @default.
• W4362658347 creator A5073739684 @default.
• W4362658347 creator A5074451234 @default.
• W4362658347 creator A5074889378 @default.
• W4362658347 creator A5075899436 @default.
• W4362658347 creator A5084573104 @default.
• W4362658347 creator A5085837561 @default.
• W4362658347 creator A5087817785 @default.
• W4362658347 creator A5088109805 @default.
• W4362658347 date "2023-04-06" @default.
• W4362658347 modified "2023-10-13" @default.
• W4362658347 title "Liver‐derived <scp>FGF21</scp> is required for the effect of time‐restricted feeding on high‐fat diet‐induced fatty liver in mice" @default.
• W4362658347 cites W1697181819 @default.
• W4362658347 cites W1967972402 @default.
• W4362658347 cites W1973196413 @default.
• W4362658347 cites W2016539998 @default.
• W4362658347 cites W2020958481 @default.
• W4362658347 cites W2050259739 @default.
• W4362658347 cites W2054119106 @default.
• W4362658347 cites W2089504088 @default.
• W4362658347 cites W2092647408 @default.
• W4362658347 cites W2100232436 @default.
• W4362658347 cites W2123319274 @default.
• W4362658347 cites W2126188293 @default.
• W4362658347 cites W2133706171 @default.
• W4362658347 cites W2166878182 @default.
• W4362658347 cites W2170065584 @default.
• W4362658347 cites W2171666144 @default.
• W4362658347 cites W2257770802 @default.
• W4362658347 cites W2561274033 @default.
• W4362658347 cites W2749688538 @default.
• W4362658347 cites W2762869502 @default.
• W4362658347 cites W2767241459 @default.
• W4362658347 cites W2767999649 @default.
• W4362658347 cites W2771903009 @default.
• W4362658347 cites W2785779482 @default.
• W4362658347 cites W2799755800 @default.
• W4362658347 cites W2889094742 @default.
• W4362658347 cites W2912766252 @default.
• W4362658347 cites W2971508249 @default.
• W4362658347 cites W3000674610 @default.
• W4362658347 cites W3003075915 @default.
• W4362658347 cites W3022765794 @default.
• W4362658347 cites W3038091087 @default.
• W4362658347 cites W3089999664 @default.
• W4362658347 cites W3117648256 @default.
• W4362658347 cites W3174562054 @default.
• W4362658347 cites W3201276384 @default.
• W4362658347 cites W3206101980 @default.
• W4362658347 cites W4231793812 @default.
• W4362658347 cites W4306895280 @default.
• W4362658347 doi "https://doi.org/10.1096/fj.202202031r" @default.
• W4362658347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37022664" @default.
• W4362658347 hasPublicationYear "2023" @default.
• W4362658347 type Work @default.
• W4362658347 citedByCount "3" @default.
• W4362658347 countsByYear W43626583472023 @default.
• W4362658347 crossrefType "journal-article" @default.
• W4362658347 hasAuthorship W4362658347A5001478855 @default.
• W4362658347 hasAuthorship W4362658347A5012677271 @default.
• W4362658347 hasAuthorship W4362658347A5027046605 @default.
• W4362658347 hasAuthorship W4362658347A5032457463 @default.
• W4362658347 hasAuthorship W4362658347A5038497872 @default.
• W4362658347 hasAuthorship W4362658347A5048025320 @default.
• W4362658347 hasAuthorship W4362658347A5052883326 @default.
• W4362658347 hasAuthorship W4362658347A5053678004 @default.
• W4362658347 hasAuthorship W4362658347A5060742506 @default.
• W4362658347 hasAuthorship W4362658347A5068306950 @default.
• W4362658347 hasAuthorship W4362658347A5073739684 @default.
• W4362658347 hasAuthorship W4362658347A5074451234 @default.
• W4362658347 hasAuthorship W4362658347A5074889378 @default.
• W4362658347 hasAuthorship W4362658347A5075899436 @default.
• W4362658347 hasAuthorship W4362658347A5084573104 @default.
• W4362658347 hasAuthorship W4362658347A5085837561 @default.
• W4362658347 hasAuthorship W4362658347A5087817785 @default.
• W4362658347 hasAuthorship W4362658347A5088109805 @default.
• W4362658347 hasConcept C106646824 @default.
• W4362658347 hasConcept C126322002 @default.
• W4362658347 hasConcept C134018914 @default.
• W4362658347 hasConcept C141359234 @default.
• W4362658347 hasConcept C149984733 @default.
• W4362658347 hasConcept C170493617 @default.
• W4362658347 hasConcept C171089720 @default.
• W4362658347 hasConcept C2776175330 @default.
• W4362658347 hasConcept C2776954865 @default.
• W4362658347 hasConcept C2777075537 @default.
• W4362658347 hasConcept C2777391703 @default.
• W4362658347 hasConcept C2778772119 @default.
• W4362658347 hasConcept C2779134260 @default.

• next