Matches in SemOpenAlex for { <https://semopenalex.org/work/W4362660977> ?p ?o ?g. }
- W4362660977 abstract "Abstract A growing body of research associates the oral microbiome and oral cancer. Well-characterized clinical samples with outcome data are required to establish relevant associations between the microbiota and disease. The objective of this study was to characterize the community variations and the functional implications of the microbiome in low-grade oral epithelial dysplasia (OED) using 16S rRNA gene sequencing from annotated archival swabs in progressing (P) and non-progressing (NP) OED. We characterised the microbial community in 90 OED samples — 30 swabs from low-grade OED that progressed to cancer (cases) and 60 swabs from low-grade OED that did not progress after a minimum of 5 years of follow up (matched control subjects). There were small but significant differences between P and NP samples in terms of alpha diversity as well as beta diversity in conjunction with other clinical factors such as age and smoking status for both taxa and functional predictions. Across all samples, the most abundant genus was Streptococcus , followed by Haemophilus , Rothia , and Neisseria. Taxa and predicted functions were identified that were significantly differentially abundant with progression status (all Ps and NPs), when samples were grouped broadly by the number of years between sampling and progression or in specific time to progression for Ps only. However, these differentially abundant features were typically present only at low abundances. For example, Campylobacter was present in slightly higher abundance in Ps (1.72%) than NPs (1.41%) and this difference was significant when Ps were grouped by time to progression. Furthermore, several of the significantly differentially abundant functions were linked to the Campylobacteraceae family in Ps and may justify further investigation. Larger cohort studies to further explore the microbiome as a potential biomarker of risk in OED are warranted." @default.
- W4362660977 created "2023-04-07" @default.
- W4362660977 creator A5001704117 @default.
- W4362660977 creator A5013908616 @default.
- W4362660977 creator A5029670273 @default.
- W4362660977 creator A5045483300 @default.
- W4362660977 creator A5059437727 @default.
- W4362660977 creator A5060238314 @default.
- W4362660977 creator A5060482328 @default.
- W4362660977 creator A5075940411 @default.
- W4362660977 creator A5076717986 @default.
- W4362660977 creator A5089589253 @default.
- W4362660977 date "2023-04-06" @default.
- W4362660977 modified "2023-10-18" @default.
- W4362660977 title "Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression" @default.
- W4362660977 cites W1630865570 @default.
- W4362660977 cites W1819796515 @default.
- W4362660977 cites W1856538661 @default.
- W4362660977 cites W1901660111 @default.
- W4362660977 cites W1972866964 @default.
- W4362660977 cites W1980173743 @default.
- W4362660977 cites W2005478409 @default.
- W4362660977 cites W2016081624 @default.
- W4362660977 cites W2034285706 @default.
- W4362660977 cites W2036897871 @default.
- W4362660977 cites W2053837661 @default.
- W4362660977 cites W2055043387 @default.
- W4362660977 cites W2055615060 @default.
- W4362660977 cites W2056279562 @default.
- W4362660977 cites W2065418645 @default.
- W4362660977 cites W2107097628 @default.
- W4362660977 cites W2110507552 @default.
- W4362660977 cites W2115699469 @default.
- W4362660977 cites W2117635193 @default.
- W4362660977 cites W2120335773 @default.
- W4362660977 cites W2140679462 @default.
- W4362660977 cites W2144656526 @default.
- W4362660977 cites W2154220394 @default.
- W4362660977 cites W2161171034 @default.
- W4362660977 cites W2164759108 @default.
- W4362660977 cites W2169961966 @default.
- W4362660977 cites W2171805075 @default.
- W4362660977 cites W2219978888 @default.
- W4362660977 cites W2328636580 @default.
- W4362660977 cites W2401404581 @default.
- W4362660977 cites W2413500105 @default.
- W4362660977 cites W2501882856 @default.
- W4362660977 cites W2510675082 @default.
- W4362660977 cites W2524463122 @default.
- W4362660977 cites W2564755845 @default.
- W4362660977 cites W2591721313 @default.
- W4362660977 cites W2611901831 @default.
- W4362660977 cites W2755818420 @default.
- W4362660977 cites W2757217416 @default.
- W4362660977 cites W2769542288 @default.
- W4362660977 cites W2771478888 @default.
- W4362660977 cites W2776152832 @default.
- W4362660977 cites W2783304790 @default.
- W4362660977 cites W2790032093 @default.
- W4362660977 cites W2797505012 @default.
- W4362660977 cites W2800461749 @default.
- W4362660977 cites W2801050647 @default.
- W4362660977 cites W2909560368 @default.
- W4362660977 cites W2937753868 @default.
- W4362660977 cites W2948144992 @default.
- W4362660977 cites W2949737921 @default.
- W4362660977 cites W2954997986 @default.
- W4362660977 cites W2963095772 @default.
- W4362660977 cites W2963276645 @default.
- W4362660977 cites W2965423269 @default.
- W4362660977 cites W2999417355 @default.
- W4362660977 cites W2999829053 @default.
- W4362660977 cites W3016742691 @default.
- W4362660977 cites W3030441098 @default.
- W4362660977 cites W3090909822 @default.
- W4362660977 cites W3103145119 @default.
- W4362660977 cites W3106931025 @default.
- W4362660977 cites W3112448915 @default.
- W4362660977 cites W3128646645 @default.
- W4362660977 cites W3162416536 @default.
- W4362660977 cites W3205866789 @default.
- W4362660977 cites W3211779138 @default.
- W4362660977 cites W4200278373 @default.
- W4362660977 cites W4225529913 @default.
- W4362660977 cites W4291464783 @default.
- W4362660977 cites W4311575706 @default.
- W4362660977 doi "https://doi.org/10.1186/s12903-023-02911-5" @default.
- W4362660977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37024828" @default.
- W4362660977 hasPublicationYear "2023" @default.
- W4362660977 type Work @default.
- W4362660977 citedByCount "2" @default.
- W4362660977 countsByYear W43626609772023 @default.
- W4362660977 crossrefType "journal-article" @default.
- W4362660977 hasAuthorship W4362660977A5001704117 @default.
- W4362660977 hasAuthorship W4362660977A5013908616 @default.
- W4362660977 hasAuthorship W4362660977A5029670273 @default.
- W4362660977 hasAuthorship W4362660977A5045483300 @default.
- W4362660977 hasAuthorship W4362660977A5059437727 @default.
- W4362660977 hasAuthorship W4362660977A5060238314 @default.
- W4362660977 hasAuthorship W4362660977A5060482328 @default.